推拿配合中药足浴熏洗治疗膝骨性关节炎的临床研究

目的 评价推拿配合中药足浴熏洗治疗膝骨性关节炎（knee osteoarthritis,KOA）的临床疗效,并观察治疗前后Lysholm膝关节功能评分(Lysholm knee score,LKSS)的变化。方法 将61例轻中度KOA患者随机分成两组,治疗组推拿配合中药足浴熏洗治疗,对照组口服美洛昔康治疗,两组均治疗20天（次）,于治疗前、治疗10天（次）、治疗结束及结束后1个月评定LKSS评分。结果 （1）治疗组临床控制13例,显效11例,有效6例,无效 1例,对照组分别为5、11、10、4例,治疗组疗效优于对照组(P<0.05)。（2）LKSS:两组治疗结束LKSS均高于治疗前, 差异有统计学意义(P<0.01);治疗10天（次）后治疗组LKSS低于对照组,但差异无统计学意义(P>0.05);治疗结束后治疗组LKSS高于对照组(P<0.05)。（3） 随访1个月需要重新接受治疗病例数及随访LKSS与治疗结束时LKSS的差值,治疗组均低于对照组(P<0.01)。结论 推拿配合中药足浴熏洗治疗KOA有较好的临床疗效。     

王琦教授应用枳术丸治疗功能型便秘的经验探讨

对于名方的应用,主要学习其制方思想,临证时既能执守,又能圆通,明其理而活其法。徐大椿在《兰台轨范·序》中言:"一病必有主方,一病必有主药。"王琦教授临床常以主病主方思想治疗疾病,针对性强,疗效显著。文章以枳术丸治疗功能性便秘为例,试论王琦教授主病主方学术思想和临床经验。     

疏血通注射液的质量工艺与用药安全的相关性

疏血通注射液是第1个动物类中药注射剂,主要成分为水蛭、地龙,拥有5项国家发明专利,是公认最强效的中药破血逐瘀剂,也是SFDA批准的药品说明书适应症中唯一明确为脑梗死急性期,临床应用最广泛的急重症抢救中药。其采用了现代生物提取技术制备,整个生产过程中仅采用生理盐水作为溶剂。采用专利工艺,最大限度地保留药效成分和活性,同时去除无效物质和易引起过敏反应的异体蛋白、大相对分子质量物质。物质基础研究已分离、鉴定出疏血通注射液中7类共56种单体化合物,相对分子质量100～1 700,主要包括多肽、糖肽、内源性小分子等。     

中药特色之一地道药材研究进展

中药材的地道性是中药的特色之一,也是影响中药质量的关键因素。从地道药材的概念、属性及影响药材地道性的因素方面对地道药材研究进展情况进行了探讨分析。     

应用ImageJ程序包进行材料显微组织图像处理、分析和可视化的一种框架(英文)

显微组织图像(例如胞、粒子与晶粒等)的数字图像处理、分割和分析,对于获取显微组织特征的三维信息非常重要。已有数种商用和共享程序包可以用于图像的处理和分析。"ImageJ"即其中之一,其长期广泛采用及其可扩展插件形式已使其成为许多不同应用领域科学家选用的工具。它包含了处理、分割、重建和可视化材料显微结构所需要的几乎所有基本的和最新的功能以及图像分析工具(例如‘Particle Analyzer’,‘3D object counter’,‘3D Roi Manager’),以用于成组粒子的复杂统计处理。虽然它在生物医学研究领域很受欢迎,被认为是一种有用的和有效的开放源码的图像处理与分析软件,但是在材料科学领域对其所知甚少。面向材料学界,本文尤其是那些没有图像处理和分析经验的材料科学与工程专业人员,在简要介绍ImageJ的基础上,提出了将其应用于在三维空间中处理、分割和分析显微组织结构连续切片图像的一个通用框架。     

Influence of core material on fracture resistance and marginal adaptation of restored root filled teeth

Aim To investigate ex vivo the influence of direct placement core materials on the fracture strength and marginal adaptation of root filled maxillary central incisors restored with glass fibre‐reinforced posts, various core materials and all‐ceramic crowns. Methodology Forty‐eight human maxillary incisors were root filled. Posts were placed and teeth restored with composite cores and crowns (n = 8). Six core materials were examined after thermal cyclic and mechanical loading (TCML). Fracture force was determined under static loading. The marginal adaptation at the interfaces between cement‐tooth and cement‐crown were categorized as ‘intact margin’ or ‘marginal gap’ using scanning electron microscopy. Statistical analysis was undertaken with the Mann–Whitney U‐test (α = P ≤ 0.05). Results Median fracture strength varied between 204 N (low viscous experimental core) and 1094 N (Multicore). No difference in fracture resistance was found with varying viscosity of the core material. The layering technique improved the fracture performance (P = 0.059) to a minor degree. Crowns with dedicated core materials (Rebilda 1063 N; Multicore 1094 N) had a significantly higher fracture resistance than crowns with a conventional restorative material (Tetric Ceram 509 N). Significantly poorer marginal adaptation before TCML was found for the layering technique at the tooth–cement interface and for all experimental cores after TCML. At the crown–cement interface significant differences in marginal adaptation could be determined between Multicore‐layered core (P = 0.002) and Multicore‐Rebilda (P = 0.001) after TCML. Conclusions The fracture strength of post and core restorations was dependent on the core material and bonding system. Marginal adaptation was influenced by the method of application of the core material and by TCML.     

Mechanical properties of provisional crown and bridge materials: chemical-curing versus dual-curing systems

OBJECTIVES: This study aimed to investigate the flexural strength (FS) and flexural modulus (FM) of provisional crown and bridge materials at different storage times after mixing using materials with different curing mechanisms (dual-curing vs. self-curing). METHODS: FS and FM of four proprietary materials (Trim, Luxatemp AM Plus, Luxatemp AM Plus Solar and Cool Temp Natural) were tested in a 3-point bending test according to EN ISO 4049:2000 at various times after mixing (37 degrees C dry/water) including thermocycling (5000x, 5-55 degrees C). Mean values of all measurements were calculated and subjected to the Games-Howell test (p=0.05) as well as a regression analysis (p=0.05). A two-way ANOVA (p=0.05) was used to identify the influence of the curing mechanism and chemical nature of the materials used. RESULTS: FS ranged between 11.1 and 24.0 MPa and FM between 82.5 and 548.2 MPa for all tested materials except for the dual-curing material (FS: 82.4 MPa; FM: 2060 MPa) 10 min after mixing. The r2-values, describing the goodness-of-fit of the regression curve for the relation between the mechanical properties and storage time, ranged from 0.701 to 0.979 for the composite based materials and 0.671 to 0.685 for the methacrylate resin. The chemical nature and curing mechanism significantly influenced (p<0.001) the mechanical properties, however, the influence of the curing mechanism disappeared at progressive points in time after mixing comparing Luxatemp AM Plus versus Luxatemp AM Plus Solar. CONCLUSIONS: FS and FM significantly depend on the time after mixing. Composite resin based materials are preferred versus methacrylate resins due to more favourable mechanical properties. If a high mechanical strength is indispensable directly after fabrication, a dual-curing provisional material is recommended.     

内源性显影栓塞材料灭菌稳定性的研究

研究探索内源性显影栓塞材料显影效果的灭菌影响因素,建立适宜的灭菌方法。探讨了湿热灭菌法、辐照灭菌法、膜过滤法对材料的灭菌效果,采用滴定方法检测材料中的碘含量,比较灭菌前后碘含量的变化以对比材料的显影效果。结果表明湿热灭菌法和辐照灭菌法虽然能有效灭菌,但是材料中的碘含量减少较多,降低了材料的显影效果;膜过滤法在有效灭菌的同时对样品中碘含量的基本没有影响,材料的显影效果不变化。内源性显影栓塞材料的最优灭菌方法为膜过滤法。     

A composite material model for improved bone formation

The combination of synthetic polymers and calcium phosphates represent an improvement in the development of scaffolds for bone‐tissue regeneration. Ideally, these composites provide both mechanically and architecturally enhanced performances; however, they often lack properties such as osteoconductivity and cell bioactivation. In this study we attempted to generate a composite bone substitute maximizing the available osteoconductive surface for cell adhesion and activity. Highly porous scaffolds were prepared through a particulate leaching method, combining poly‐ε‐caprolactone (PCL) and hydroxyapatite (HA) particles, previously coated with a sucrose layer, to minimize their embedding by the polymer solution. Composite performances were evaluated both in vitro and in vivo. In PCL–sucrose‐coated HA samples, the HA particles were almost completely exposed and physically distinct from the polymer mesh, while uncoated control samples showed ceramic granules massively covered by the polymer. In vivo results revealed a significant extent of bone deposition around all sucrose‐coated HA granules, while only parts of the control uncoated HA granules were surrounded by bone matrix. These findings highlight the possibility of generating enhanced osteoconductive materials, basing the scaffold design on physiological and cellular concepts. Copyright © 2010 John Wiley & Sons, Ltd.