Computed tomographic changes of the brain and clinical outcome of patients with seizures and epilepsy after an ischaemic hemispheric stroke.

It is not well established whether seizures and epilepsy after an ischaemic stroke increase the disability of patients. Seventy-two patients with delayed seizures after a hemispheric infarct (37 with a single seizure and 35 with epilepsy) were included in the study. The modified Rankin scale was used to compare disability of the patients at 1 month after stroke and at 2 weeks after single or the last seizure, in case of epilepsy. The size of the X-ray hypoattenuation zone was compared on computed tomographic (CT) scans, performed in the weeks after the stroke and 1 week after single or repeated seizures. Lesion size was determined by superimposing the CT slices on digital cerebral vascular maps, on which the contours of the infarct area were delineated. The extent of the infarcts was expressed as the percentage fraction of the total surface area of the cerebral hemisphere. Groups with a single seizure and with epilepsy were mutually compared. Infarcts predominated in the parieto-temporal cortical regions. In the overall group the median Rankin score worsened significantly after seizures. The average size of the X-ray hypoattenuation zone was also significantly increased on the CT scans after the seizures, compared with those after stroke, without clear evidence of recent infarction. Mutual comparison of patients with a single seizure episode and of those with epilepsy showed only a trend of more severe disability and of increase in lesion size in the post-stroke epilepsy group. Delayed seizures and epilepsy after ischaemic stroke are accompanied by an increase in lesion size on CT and by worsening of the disability of the patients. This study does not allow to determine whether this is due to stroke recurrence or due to additional damage as a result of the seizures themselves.     

外伤后癫痫大鼠模型脑内铁蛋白与转铁蛋白含量的动态变化研究

目的:从脑内铁代谢的角度研究铁在外伤后癫(PTE)发病机制中的可能作用。方法:用ELISA方法检测PTE大鼠模型脑组织内铁蛋白(Ft)和转铁蛋白(Tf)的动态含量。结果:早期Ft在整个脑组织内呈现为即刻反应性升高,15d后其含量在实验对侧脑组织内恢复至正常范围,而在实验侧脑组织内呈现继续升高的趋势;Tf含量只在实验侧脑组织内升高,且呈现随时间继续升高趋势。结论:PTE大鼠模型中的铁代谢过程十分复杂,相关蛋白尤其是Tf含量的增加提示铁可能是外伤后癫灶形成机制的一部分。     

The effect of the fiber components cellulose and lignin on experimental colon neoplasia

Sixty Sprague-Dawley rats were pair-fed one of three nutritionally identical diets. One diet contained “low-fiber” (3.8% crude fiber); the others contained “high fiber” (28.7% crude fiber) composed of either cellulose or lignin. Although both “high fiber” diets had similar stool bulking effects, only the cellulose diet was associated with a reduction in 1,2-dimethylhydrazine (DMH)-induced colon neoplasms. The cellulose diet was also associated with distinct changes in the gut bacterial profile and with a lowered serum cholesterol. © 1993 Wiley-Liss, Inc.     

Age, fiber type composition and in vitro contracture responses in human malignant hyperthermia

Muscle fiber typing and in vitro contracture tests were performed in 59 patients investigated for susceptibility to malignant hyperthermia (MH). Eighteen patients were found to be susceptible to MH. There was no difference in age or fiber type distribution between MH susceptible and non-susceptible patients. No correlation was found between age and fiber type distribution. Separate analyses for each diagnostic group revealed no relationship between age or fiber type distribution and response to halothane or caffeine. When all caffeine results were pooled, however, there was a significant effect of age on the caffeine specific concentration (the concentration eliciting a contracture of 1 g), but not on the caffeine threshold concentration (the minimal concentration eliciting an increase in tension). It is concluded that age and fiber type distribution have no influence on MH diagnosis, if the protocol of the European MH Group for evaluation of susceptibility to MH is followed.     

小儿与成人喉内肌肌纤维型的差异与喉功能的关系

通过对１０例小儿及２３例成年人的喉内肌进行的ｍｙｏｓｉｎ－ＡＴＰａｓｅ等染色观察，得到小儿和成人各喉内肌不同的肌纤维构成比。成人ＰＣＡⅠ型纤维最多，ＬＣＡ、ＩＮＡ及ＣＴ次之，ＴＡ最少。小儿的各喉内肌也有类似比例。表明不论小儿或成人，ＰＣＡ均具有较强的抗疲劳性，适应呼吸作用的需要；ＴＡ具有较快的收缩速度，以适应发声及呼吸道保护作用。从纤维构成上看，小儿与成人相比，各喉内肌Ⅰ型纤维较为匮乏，表明小儿的喉在发声及呼吸道保护等功能方面尚不够完善。     

玻璃纤维增强复合树脂在总义齿基托中的应用

目的：增强总义齿基托的机械性能，提高总义齿的基托抗折裂能力。方法：对E－玻璃纤维用KH－550处理剂进行表面处理后，加入总义齿基托中，制成玻璃纤维增强复合树脂。结果：经过1年的临床观察后复诊，没有发现裂纹。结论：玻璃纤维增强得合树脂可以有效地增强总义齿基托的机械性能。     

杂多阴离子对SiO_2细胞毒性的拮抗作用

本文采用离体细胞培养法,以细胞存活率、乳酸脱氢酶活性和酸性磷酸酶活性为指标,研究了几种α-Keggin结构的杂多阴离子对石英粉尘细胞毒性的影响。结果表明,与对照组比较,所用杂多阴离子无细胞毒性(P>0.05),石英尘经杂多阴离子作用后,细胞毒性显著降低,与石英尘组比较,上述三项指标差异均有显著意义(P<0.01),由此表明杂多阴离子对石英的细胞毒性有明显的拮抗作用。     

利用Matlab和Ansys workbench软件辅助建立桩核冠三维有限元模型

目的:利用Matlab和Ansysworkbench软件辅助建立桩核冠三维有限元模型。方法:应用薄层CT技术,获取建模所需二维影像45张(层厚0.5mm,无间隔),利用Matlab软件编程读取图像边界数据,导入Ansys三维有限元专用软件,在Ansysworkbench环境中三维重组模型,同时进行模型单元划分和力学检测。结果:建立包含桩核、冠修复体、牙根、粘固剂、牙胶尖、牙周膜、松质骨和皮质骨的三维有限元模型。结论:利用Matlab软件和Ansysworkbench软件辅助建模,提高了建模的精度、速度和灵活性,为牙颌组织三维有限元建模提供了新的方法。     

Infection dynamics and virus-induced apoptosis in cell culture-based influenza vaccine production—Flow cytometry and mathematical modeling

Cell culture-based influenza vaccine manufacturing is of growing importance. Depending on virus strains, differences in infection dynamics, virus-induced apoptosis, cell lysis and virus yields are observed. Comparatively little is known concerning details of virus–host cell interaction on a cellular level and virus spreading in a population of cells in bioreactors. In this study, the infection of MDCK cells with different influenza A virus strains in lab-scale microcarrier culture was investigated by flow cytometry. Together with the infection status of cells, virus-induced apoptosis was monitored. A mathematical model has been formulated to describe changes in the concentration of uninfected and infected adherent cells, dynamics of virus particle release (infectious virions, hemagglutinin content), and the time course of the percentage composition of the cell population.     

Propriospinal myoclonus: utility of magnetic resonance diffusion tensor imaging and fiber tracking.

Propriospinal myoclonus (PSM) is a rare movement disorder characterized by involuntary spinal-generated muscular jerks that spread rostrally and caudally to other spinally innervated muscles. Most patients have no clear etiology, and conventional MRI of the spinal cord is generally normal. Here we report the use of magnetic resonance diffusion tensor imaging (DTI) and fiber tracking to detect tract-specific abnormalities in a patient with propriospinal myoclonus. As the patient had the fragile-X premutation and antithyroid antibodies, spinal cord DTI abnormalities may be related to these conditions. Tract-specific analysis may provide new insights into the pathophysiology of propriospinal myoclonus.