维吾尔族翼状胬肉自体角膜干细胞移植128例疗效分析

目的:分析自体角膜缘干细胞移植术治疗翼状胬肉的疗效。方法:对128例维吾尔族单眼行翼状胬肉切除联合自体角膜缘干细胞移植,以角膜上皮愈合,恢复透明,无胬肉样组织生长为治愈,否则为复发。结果:126例治愈,2例复发,复发率为1.6%。结论:自体角膜缘干细胞移植治疗翼状胬肉是可行的,能有效防止复发。     

大范围切除联合新鲜羊膜移植治疗复发性翼状胬肉

目的:观察大范围切除联合新鲜羊膜移植术在治疗复发性翼状胬肉的临床疗效。方法:对复发性翼状胬肉47例50眼在显微镜下行大范围翼状胬肉切除联合新鲜羊膜移植术,观察术后胬肉复发及眼表修复情况。结果:术后随访观察6～36mo,4眼复发,46眼治愈,复发率为8%。结论:大范围翼状胬肉切除联合新鲜羊膜移植治疗复发性翼状胬肉能够有效降低胬肉的复发,且羊膜取材方便,手术操作简单,有利于基层医院开展。     

肉眼下翼状胬肉切除联合自体角膜缘干细胞移植临床分析

目的 观察肉眼下翼状胬肉切除联合自体角膜缘干细胞移植治疗翼状胬肉的临床疗效.方法 对150例(150只眼)原发翼状胬肉患者在肉眼下行翼状胬肉切除联合自体角膜缘干细胞移植,观察术后复发情况.结果 术后随诊1～12个月,10例复发,复发率为6.67%.结论 肉眼下翼状胬肉切除联合自体角膜缘干细胞移植治疗原发翼状胬肉,能有效降低胬肉术后复发率,是目前医疗条件下较为理想的手术方法.     

改良性带蒂结膜瓣移植治疗翼状胬肉的疗效观察

目的:对改良性带蒂结膜瓣移植治疗翼状胬肉的有效性进行观察。方法:复发性翼状胬肉患者35例35眼,施行改良性带蒂结膜瓣移植手术治疗翼状胬肉,术后随访6mo～1a,观察疗效及复发情况。结果:35眼复发性翼状胬肉,2眼(6%)复发。讨论:改良性带蒂结膜瓣移植手术治疗翼状胬肉,手术方便,复发率低,疗效可靠。     

改良逆行撕剥术联合自体结膜瓣移植治疗翼状胬肉的临床观察

目的:观察改良逆行撕剥术联合自体结膜瓣移植治疗翼状胬肉的临床效果。方法:通过对49例56眼行改良逆行撕剥术联合自体结膜瓣移植治疗,手术后随访12mo。结果:随访期间56眼中2眼复发。结论:改良逆行撕剥术联合自体结膜瓣移植具有操作简单、疗效可靠、复发率低的特点,值得临床推广。     

手术切除联合自体血清滴眼液治疗翼状胬肉的疗效观察

目的观察翼状胬肉切除术后局部滴用自体血清滴眼液对创面修复的临床疗效。方法治疗组翼状胬肉16眼采用单纯翼状胬肉切除术联合局部滴用自体血清滴眼液治疗,对照组翼状胬肉16眼采用单纯翼状胬肉切除术治疗。结果治疗组术后3d时自觉症状明显减轻,2周时11眼充血完全减退;对照组4d时畏光、流泪开始减轻,2周时6眼充血完全减退。角膜上皮平均修复时间治疗组（3．34±1．52）d与对照组（4．45±1．49）d相比差异有统计学意义（t=2．09,P〈0．05）。治疗组术后11眼视力有提高,对照组4眼视力提高,两组对比差异有统计学意义（χ^2=5．24,P〈0．05）。治疗组1眼复发,对照组2眼复发,两组均无感染。结论翼状胬肉切除术后局部应用自体血清滴眼液可缩短角膜上皮的修复时间,减少了复发和感染机会。自体血清滴眼液制作简单,患者耐受性好。     

翼状胬肉切除自体带结膜瓣角膜缘干细胞移植

目的 评价自体带球结膜瓣的角膜缘干细胞移植治疗翼状胬肉的效果方法在手术显微镜下用带球结膜瓣的自体角膜缘干细胞移植治疗初发性、复发性翼状胬肉36例(40眼)，术后随访6～18月。结果 34例(38眼)治愈，其中2例(2眼)复发，治愈率为95．0％。结论 带球结膜瓣的角膜缘干细胞移植有助于角膜、结膜的重建，阻止新生血管的侵入，有效的抑制了胬肉的复发。     

人羊膜移植治疗翼状胬肉等眼表疾病的临床观察

目的：观察用人羊膜移植术治疗翼新诗胬肉、角膜热灼伤、化学伤、睑球粘连等眼表疾病的临床疗效。方法：用人羊膜移植术治疗翼状胬肉46例65只眼，其中复发性胬肉16只眼，假性翼状胬肉1只眼，角膜热灼伤、化学伤3例4只眼，睑球粘连2例2只眼，手术均在显微镜下完成。结果：随访3-11个月，羊膜移植手术均一次成功，无免疫排斥反应。翼状胬肉组，角膜透明，无新生血管，巩膜面结膜覆盖良好，充血消失；2只眼复发，复发率为3.1％，成功率96.9％。3例（4只眼）角膜热灼伤、化学伤者，术后均未见继续溶解、穿孔。睑球粘连者，结膜囊形成，睑球粘连者，结膜囊形成，睑球粘连松解，眼球活动基本正常。结论：人羊膜移植是治疗翼状胬肉等眼表疾病较有效方法，它可抑制结膜下及角膜纤维化，促进结膜、角膜的上皮化。     

羊膜移植治疗翼状胬肉

目的 现察羊膜移植治疗翼状胬肉的疗效，探讨羊膜移植是否可替代结膜移植治疗翼状胬肉。方法 对44例44眼翼状胬肉行胬肉切除，26眼行羊膜移植，18眼行结膜移植。术后定期随访，现察疗效和眼表情况。结果 羊膜移植组平均随访28月，手术成功率84．6％6；结膜移植组平均随访15．8月，手术成功率83．3％．结论 羊膜移植可替代结膜移植治疗翼状胬肉。     

Overexpression of type Ⅰ growth factor receptors in pterygium

Objective To evaluate the expression of the type Ⅰ growth factor receptor family ［epider mal growth factor receptor (EGFR), ErbB2 and ErbB3］ by the epithelial cells in pterygium. Methods Immunoflurescent staining and Western blotting were performed to detect the expr ession pattern and quantity of EGFR, ErbB2 and ErbB3 proteins in the epithelia o f 15 patients with primary pterygium and 12 subjects with normal conjunctiva. Results In immunofluorescent staining, the EGFR protein was present in the basal cells w hile the ErbB2 and ErbB3 were expressed by the superficial cells in normal conju nctival epithelium. Of the pterygium cases 15, 11 were stained by EGFR, ErbB2 a nd ErbB3 in the full thickness of the epithelium and showed stronger staining co mpared with the control group. Four of them showed a similar staining pattern t o the normal conjunctiva group. The density of protein bands detected by Wester n blotting for all three growth factor receptors was consistent with the immunof luorescent staining. Compared with normal conjunctiva, stronger protein bands o f these three receptors were found in all of the pterygium specimens, in which E GFR, ErbB2 and ErbB3 were expressed in the full thickness, as shown by immunoflu orescent staining. Conclusions The increased expression of EGFR, ErbB2 and ErbB3 proteins was present in ptery gium, which indicated that pterygium is a disorder with abnormal proliferation. The abnormal expression of EGFR, ErbB2 and ErbB3 by the epithelium and the comm unication with cytokines in the stroma in pterygium may be a key pathogenic fac tor in this disorder.