全文获取类型
收费全文 | 34926篇 |
免费 | 3360篇 |
国内免费 | 403篇 |
专业分类
耳鼻咽喉 | 325篇 |
儿科学 | 2048篇 |
妇产科学 | 405篇 |
基础医学 | 3838篇 |
口腔科学 | 535篇 |
临床医学 | 3054篇 |
内科学 | 2477篇 |
皮肤病学 | 217篇 |
神经病学 | 14691篇 |
特种医学 | 331篇 |
外科学 | 1107篇 |
综合类 | 2642篇 |
现状与发展 | 2篇 |
一般理论 | 1篇 |
预防医学 | 3007篇 |
眼科学 | 131篇 |
药学 | 2840篇 |
7篇 | |
中国医学 | 828篇 |
肿瘤学 | 203篇 |
出版年
2024年 | 157篇 |
2023年 | 863篇 |
2022年 | 1264篇 |
2021年 | 1806篇 |
2020年 | 1709篇 |
2019年 | 1628篇 |
2018年 | 1499篇 |
2017年 | 1583篇 |
2016年 | 1629篇 |
2015年 | 1417篇 |
2014年 | 2321篇 |
2013年 | 3252篇 |
2012年 | 1816篇 |
2011年 | 2215篇 |
2010年 | 1708篇 |
2009年 | 1690篇 |
2008年 | 1761篇 |
2007年 | 1607篇 |
2006年 | 1322篇 |
2005年 | 1112篇 |
2004年 | 901篇 |
2003年 | 821篇 |
2002年 | 722篇 |
2001年 | 509篇 |
2000年 | 413篇 |
1999年 | 358篇 |
1998年 | 399篇 |
1997年 | 326篇 |
1996年 | 245篇 |
1995年 | 203篇 |
1994年 | 173篇 |
1993年 | 160篇 |
1992年 | 157篇 |
1991年 | 152篇 |
1990年 | 129篇 |
1989年 | 122篇 |
1988年 | 110篇 |
1987年 | 83篇 |
1986年 | 44篇 |
1985年 | 74篇 |
1984年 | 49篇 |
1983年 | 31篇 |
1982年 | 51篇 |
1981年 | 25篇 |
1980年 | 21篇 |
1979年 | 16篇 |
1978年 | 11篇 |
1977年 | 10篇 |
1976年 | 8篇 |
1974年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
Abstract Chorea is a rare complication of polycythaemia vera. Polycythaemic chorea occurs predominantly in females and usually in generalised
form. We present a 66-year-old woman with acute onset hemichorea-ballism with no vascular pathology in the basal ganglia region.
A clear relationship was observed between the onset of chorea and worsening of haematological parameters in the patient. After
repeated phlebotomies the patient's clinical status was improved. Polycythaemic chorea must be considered, especially in the
elderly, as early diagnosis leads to effective treatment and prevention of complications. 相似文献
52.
Gerald T Voelbel Marsha E Bates Jennifer F Buckman Gahan Pandina Robert L Hendren 《Neuropsychopharmacology》2006,60(9):942-950
BACKGROUND: Impaired neuropsychological test performance, especially on tests of executive function and attention, is often seen in children diagnosed with autism spectrum disorders (ASD). Structures involved in fronto-striatal circuitry, such as the caudate nucleus, may support these cognitive abilities. However, few studies have examined caudate volumes specifically in children with ASD, or correlated caudate volumes to cognitive ability. METHODS: Neuropsychological test scores and caudate volumes of children with ASD were compared to those of children with bipolar disorder (BD) and of typically developing (TD) children. The relationship between test performance and caudate volumes was analyzed. RESULTS: The ASD group displayed larger right and left caudate volumes, and modest executive deficits, compared to TD controls. While caudate volume inversely predicted performance on the Wisconsin Card Sorting Test in all participants, it differentially predicted performance on measures of attention across the ASD, BD and TD groups. CONCLUSIONS: Larger caudate volumes were related to impaired problem solving. On a test of attention, larger left caudate volumes predicted increased impulsivity and more omission errors in the ASD group as compared to the TD group, however smaller volume predicted poorer discriminant responding as compared to the BD group. 相似文献
53.
Samir Kumar Praharaj mbbs md dpm Nishant Goyal mbbs md dpm Sukanto Sarkar mbbs md dpm Dhruv Bagati mbbs Prakriti Sinha mp hil Vinod Kumar Sinha mbbs md dpm 《Psychiatry and clinical neurosciences》2009,63(2):230-234
Reported herein is a case of obsessive–compulsive disorder with persistent and distressing musical obsessions along with other symptoms. Advanced source analysis of electroencephalographic data indicated high spectral power over the bifrontal region. The musical symptoms were resistant to pharmacotherapy but there was some reduction in frequency and duration of musical obsessions with thought-stopping technique. 相似文献
54.
H. J. J. Kars Juha M. Hijmans Jan H. B. Geertzen Wiebren Zijlstra 《Journal of diabetes science and technology》2009,3(4):931-943
The objective of this review is to identify and review publications describing the impact of reduced somatosensation on balance. Based on knowledge of the association between specific somatosensory loss and deterioration of balance, conclusions can be made about role of somatosensation in standing balance.A systematic literature review is presented in which publications from the years 1993 through 2007 were searched in Medline and Embase. Medical Subject Headings (MESH) terms and free text words (related to balance, somatosensory loss, and lower limb) were used to perform the searches. Fifteen articles were selected for detailed review based on predetermined inclusion criteria, and three of the included articles described the effect of experimentally reduced somatosensation on balance in healthy subjects. Ten of the articles described balance in diabetic neuropathy (DN). The last two included articles described balance in Charcot-Marie-Tooth (CMT) disease type 1A (CMT1A) or type 2 (CMT2).The literature indicates that the tactile sensation is reduced in DN, CMT1A, and CMT2 and when the plantar surface of the feet was hypothermically anesthetized. Joint motion sensation seems to be impaired in patients with DN, and passive joint position sensation appears to be reduced in healthy subjects with anesthesia of ankle and foot from prolonged ischemia. This reduced somatosensation seems to have a negative effect on balance in patients with DN and CMT2; however, this appeared not to be the case in patients with CMT1A and in healthy subjects. 相似文献
55.
Joan M. Farrell Ida A. Shaw 《Journal of behavior therapy and experimental psychiatry》2009,40(2):317-328
This study tests the effectiveness of adding an eight-month, thirty-session schema-focused therapy (SFT) group to treatment-as-usual (TAU) individual psychotherapy for borderline personality disorder (BPD). Patients (N = 32) were randomly assigned to SFT-TAU and TAU alone. Dropout was 0% SFT, 25% TAU. Significant reductions in BPD symptoms and global severity of psychiatric symptoms, and improved global functioning with large treatment effect sizes were found in the SFT-TAU group. At the end of treatment, 94% of SFT-TAU compared to 16% of TAU no longer met BPD diagnosis criteria (p < .001). This study supports group SFT as an effective treatment for BPD that leads to recovery and improved overall functioning. 相似文献
56.
57.
58.
Mani N Pavuluri Megan Marlow O'Connor Erin Harral John A Sweeney 《Neuropsychopharmacology》2007,62(2):158-167
BACKGROUND: Facial emotions are central to human interaction. Identifying pathophysiology in affect processing circuitry that supports the ability to assess facial emotions might facilitate understanding of affect regulation in pediatric bipolar disorder. METHODS: Ten euthymic, unmedicated pediatric bipolar patients and 10 healthy control subjects matched for age, gender, race, socioeconomic status, and IQ were scanned with functional magnetic resonance imaging. Angry, happy, and neutral faces were presented in 30-sec blocks, with a 20-sec rest period between blocks. Subjects were asked to press a button when each face appeared, to ensure that attention was maintained on-task. RESULTS: In bipolar patients, in response to both angry and happy faces relative to neutral faces, we observed reduced activation of right rostral ventrolateral prefrontal cortex together with increased activity in right pregenual anterior cingulate, amygdala, and paralimbic cortex. Bipolar patients also showed reduced activation of visual areas in occipital cortex together with greater activation in higher-order visual perceptual areas, including superior temporal sulcus and fusiform gyrus with angry faces and posterior parietal cortex with happy faces. CONCLUSIONS: Findings document a disturbance in affective neurocircuitry in pediatric bipolar disorder. Reduced activation in ventrolateral prefrontal cortex might reflect diminished top-down control that leads to the observed exaggerated activation in amygdala and paralimbic areas. Changes in occipital areas might represent an effort to gate sensory input when affective responses to the faces could not be successfully modulated. Disturbances in affect processing circuitry could contribute to emotional dysregulation and social cognitive difficulties in bipolar youth. 相似文献
59.
We report a 51-year-old patient with severe haemophilia A developing a severe life-threatening anaphylactic reaction to recombinant factor VIII (rFVIII). Anaphylactic reactions are a rare but well-known side effect of FVIII products. The nature of these reactions could not be clarified as previous studies failed to demonstrate a specific IgE response. Here, we could prove a grade 3 anaphlyactic reaction as an IgE-mediated response to rFVIII for the first time by Western blotting. 相似文献
60.
烧伤后机体应激导致代谢紊乱,表现为严重高分解代谢,机体损耗和抵抗力下降,严重影响患者预后。临床上主要采用生理营养指标、实验室诊断指标和能量消耗测定3类检测指标对机体代谢状况进行诊断评估,继而通过药物治疗结合非药物治疗手段加以调理支持,促进烧伤修复。目前,仍有多种诊断治疗方法尚未普及或有待完善。 相似文献