子宫内膜增生症及早期子宫内膜癌保留生育功能后冻胚移植妊娠结局

目的 探讨子宫内膜复杂性增生/不典型增生/早期子宫内膜癌保留生育力治疗后冻胚移植子宫内膜准备方案对妊娠结局的影响。方法 回顾性分析2015年1月至2020年12月于山东大学附属生殖医院门诊经体外受精或卵细胞质内单精子注射行冻胚移植的经保留生育功能治疗后逆转的子宫内膜复杂性增生/不典型增生/早期子宫内膜癌患者的临床资料,纳入了112例患者的179个冻胚移植周期,按冻胚移植子宫内膜准备方案分为4组：自然周期组(n=29)、促排卵周期组(n=38)、直接替代周期组(n=89)、降调+替代周期组(n=23)。比较分析各组的临床特征和妊娠结局,采用二分类Logistic回归分析影响患者活产率的因素。结果 在179个周期中,促排卵周期组与自然周期组、直接替代周期组和降调+替代周期组比较,其妊娠周期活产率(34.2%、31.0%、31.5%、30.4%)、活产率(46.7%、31.8%、34.8%、22.2%)、妊娠周期临床妊娠率(52.6%、37.9%、49.4%、43.5%)、妊娠周期生化妊娠率(65.8%、44.8%、64.0%、47.8%)更高,自然周期组妊娠周期流产率低于其他3组(18.2...     

延长油田职工糖代谢异常患病情况调查

目的了解延长油田职工糖代谢异常情况,为制定防治措施提供理论依据。方法采用整群抽样的方法,对甘谷驿采油厂的全体职工进行问卷调查、人体学测量及相关生化指标检测,分析糖代谢异常的流行病学特征及危险因素。结果延长油田职工中糖尿病及糖尿病前期的患病率分别为9.8%和22.8%,均高于延安市居民平均水平。男性患病率高于女性,且患病率随年龄增长而增加(P<0.05)。糖代谢异常在超重、肥胖、高血压病、高尿酸血症及血脂异常人群中患病率较正常人群组偏高(P<0.05)。结论延长油田职工糖尿病及糖尿病前期患病率高于当地平均水平,应加强对职工的健康宣教,预防包括超重、肥胖及糖代谢异常在内的多重危险因素,减少心脑血管疾病的发生。     

聚氨酯凝胶预聚物对传统树脂基质体积收缩的影响及对其综合性能的改善作用

目的:合成一种光反应性聚氨酯(PU)凝胶预聚物IBGBMA,并探讨其对传统树脂基质体积收缩和机械性能的影响.方法:通过溶液法,以异氟尔酮二异氰酸酯、双酚-A和甲基丙烯酸羟乙酯等为原料,以1,4-丁二醇和三羟基甲基丙烷为扩链剂和交联剂合成一种光反应性PU凝胶预聚物IBGBMA,实现其与光固化树脂基质的化学结合,通过傅里叶...     

腹腔镜联合药物治疗卵巢子宫内膜异位症囊肿105例疗效分析

目的观察腹腔镜联合药物治疗卵巢内异症囊肿疗效。方法选取2006年1月至2010年1月成都市第七人民医院腹腔镜联合药物治疗卵巢内异症患者105例,腹腔镜手术联合孕三烯酮治疗组(A组)62例,腹腔镜手术联合甲地孕酮治疗组(B组)43例。所有患者随访3～12个月,对症状缓解情况,术后复发率及受孕率进行比较分析。结果 A组有效率44.1%,B组有效率78.0%,B组疗效明显高于A组(P<0.05)。结论腹腔镜联合甲地孕酮可作为卵巢内异症囊肿有效的治疗方法,疗效优于孕三烯酮。     

电针缓解吗啡戒断大鼠的心动过速

目的：建立吗啡戒断大鼠心动过速模型，观察不同频率电针对其心率的影响。方法：给大鼠连续注射递增量吗啡８天，造成其对吗啡依赖。停药后１８～２４ｈ给于强度为１ｍＡ，频率为２Ｈｚ、１５Ｈｚ、１００Ｈｚ的电针刺激，记录清醒状态下吗啡戒断大鼠的心率和血压。结果：与正常大鼠比较吗啡戒断大鼠心率显著增快（Ｐ〈０．０１），但平均动脉压无显著性差异。１５Ｈｚ和１００Ｈｚ电针对吗啡戒断大鼠的心动过速均有显著抑制作用（使     

Enhancing the Reliability in the Noninvasive Measurement of the His Bundle Magnetic Field Using a Novel Signal Averaging Methodology

Background: Extraction of the weak electrical activity of the “His Bundle” (HB) by noninvasive methods has not been very successful in the past. The study reassesses the use of signal averaged magnetocardiography (SAMCG), overcoming some of the limitations in earlier studies including in the signal averaging methodology. Methods: SAMCG on healthy subjects (14 male and 1 female) were performed using R‐peak as the fiducial point in all cases and also using QRS‐onset as the fiducial point in select cases. Results: A conspicuous feature (H) with a magnitude up to 200 femto Tesla (fT) attributed to the HB activity was observed in the PR segment at several spatial positions on the thorax, with onset at 35–50 ms before the QRS‐onset (V) in 15 out of 18 trials constituting 83% of cases studied. The QRS‐onset as the fiducial point resolved the feature better compared to the conventionally used R‐peak, especially in trials exhibiting spread in heart rate (HR). This is attributed to the fluctuations in Q_onRD (the time interval between QRS‐onset and R‐peak) compared to the temporal stability of the H‐V duration. Conclusions: SAMCG reveals a well‐resolved H feature. The double hump morphology of the feature extended at least up to a frequency of 150 Hz. The importance of the choice of QRS‐onset as the fiducial point is unequivocally demonstrated, illustrated by measurements on subjects exhibiting considerable heart rate variability. The latter has a general validity and should be applicable to SAECG as well.     

2008-2011年产气肠杆菌的临床分布及耐药性分析

目的 分析产气肠杆菌临床分布特点及对常用抗菌药物的耐药性变化,以更好地指导临床的合理使用抗菌药物.方法 采用WHONET5软件统计分析2008年1月-2011年12月临床分离的产气肠杆菌临床分布和耐药率.结果 4年内共分离到产气肠杆菌459株,其中2008-2011年分别检出108、101、130、120株;病原菌主要来源于住院患者的痰液213株占46.4％、胆汁70株占15.3％、血液51株占11.1％、尿液50株占10.9％;4年耐药监测显示,亚胺培南和美罗培南的耐药率在2.0％～7.9％,呈明显的逐年上升趋势;头孢类抗菌药物除头孢唑林耐药率较高约90.0％外,其他如头孢替坦、头孢曲松、头孢他啶、头孢吡肟等耐药率由最高的55.5％下降至最低28.5％,氨苄西林/舒巴坦、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦等复合制剂耐药率也由最高70.2％下降至最低21.1％,同时阿米卡星、庆大霉素等氨基糖苷类等药物的耐药率亦呈下降趋势,最高30.4％,最低为0,对喹诺酮类的耐药率约30.0％,保持相对稳定.结论 4年产气肠杆菌对头孢菌类、氨基糖苷类、复合制剂等药物的耐药率有所降低,而碳青霉烯类药物的耐药率呈上升趋势,说明细菌耐药性存在动态的变化,及时对细菌耐药性进行分析,依据药敏结果合理选用抗菌药物,严格掌握适应证,可减少或延缓耐药菌株的播散.     

Third International Meeting on Progress in Radio-Oncology

Summary

Phthalocyanines are photosensitizers evaluated for use in photodynamic therapy of cancer. As such, the dependence of the bioresponse on the light fluence rate may be of clinical importance. The effect of the fluence rate of white light from 0·165 to 3·3 kJ m^?2 min^?1 was studied in Chinese hamster cells and human lymphocytes, using as endpoints colony-forming ability and inhibition of [³H]thymidine incorporation following mitogenic stimulation and dye-photoactivation, respectively. Using Chinese hamster cells exposed to photoexcited chloroaluminium phthalocyanine tetrasulphonate in PBS solution, cytotoxicity was diminished as the fluence rate was reduced. In human lymphocytes changing the fluence rate between 0·33 and 3·3 kJ m^?2 min^?1 affected the response in a way similar to that of Chinese hamster cells. Human lymphocytes, when exposed to incremental increasing light fluences, 4 h after a conditioning dose, were able to recover from phthalocyanine-induced photo-damage, as evidenced by the reappearance of a shoulder on the dose-effect curve. This recovery process during a protracted light exposure, could explain the reduced sensitivity to phthalocyanine photosensitization, compared to exposure at high fluence rates.     

Chronobiologically Explored Effects of Telmisartan

Effects of Micardis (Telmisartan), alone or with low-dose aspirin, on blood pressure and other cardiovascular endpoints are examined in 20 patients with MESOR-hypertension in a crossover, double-blind, randomized study consisting of three stages, each lasting 7 days: I-placebo, II-Micardis, and III-Micardis with low-dose aspirin. Treatment was administered each day at a different circadian stage, upon awakening, and 3, 6, 9, 12, 15 and 18 hr after awakening. During each stage, the following variables were measured at 3-hr intervals during waking: systolic and diastolic blood pressure, heart rate, ejection fraction, intrarenal resistive index, acceleration time, and serum creatinine. Each data series was analyzed by single cosinor. Results were summarized by population-mean least squares spectra. At matched treatment times, the MESOR and circadian amplitude of each variable were compared among the three treatments by paired t-tests. A prominent circadian rhythm characterizes all variables. Micardis was associated not only with a lowering of blood pressure, but also with a reduction of the circadian blood pressure amplitude. The ejection fraction was increased, and the resistive index and acceleration time were decreased, the effect being more pronounced when low-dose aspirin was added to Micardis. Any circadian-stage dependent effect of Micardis, with or without low-dose aspirin, will require monitoring over spans longer than a single day for a given treatment administration time.