国产安吖啶治疗急性白血病Ⅱ期临床试用

应用国产安吖啶对11例急性白血病进行诱导缓解化疗,初治6例,复治5例。4例达完全缓解(CR),CR率为36.4％。其中初治者为33.3％(2/6),复治者为40％(2/5)。总有效率45.5％。该药的剂量限制性毒性反应为骨髓抑制,部分病例有肝功能损害。     

刺五加制剂对老年人恒定负荷下运动耐力的影响

以１３名５０～５７岁志愿者为试验对象，研究了刺五加制剂对人体运动能力的影响。结果表明服用刺五加制剂后，在４５０ｋｇ．ｍ／ｍｉｎ（７５Ｗ）持速恒定功率负荷运动时呼吸商由０．９６下降至０．８８，使运动时脂肪供能增加２７．２％；心率下降８．７％，每博摄氧量增加１６．１８％。结果均提示刺五加制剂能提高人体摄氧能力，节省肌糖元，从而发挥抗疲劳作用     

三次抛物线配合方法在碘缺乏病区居民患病率分析中的应用

<正>在碘缺乏病区,居民甲状腺肿患病率在年鹅分布上的特征,可用二次抛物线加以描述[l].根握资料类型的不同,可选择更为适合的三次抛物线来描述.根据现场调查资料,本文采用三次抛物线方法进行配合,并将配合结果与二     

Effects of gender,age, and heart rate on QT intervals in children

The objective of this study was to determine if gender, age, and heart rate affect corrected QT intervals in children. Electrocardiograms were obtained from 781 healthy children 10–18 years of age. Corrected QT intervals were significantly (p < 0.0005) greater for girls than for boys in the entire population and for each age group over 14 years. The corrected QT interval varied inversely with age and directly with heart rate. Hence gender, age, and heart rate should be considered when diagnosing long QT syndrome.     

广州地区1976～1995年0～14岁儿童死因调查分析

为了解广州地区儿童死亡原因的变迁规律，我们对广州地区1976～1995年0～14岁儿童死亡原因年报表作了统计分析，揭示了儿童的总死亡率、各主要死亡疾病的死亡率及其构成和死因顺位。结果显示，传染性疾病的死亡率已明显下降，新生儿疾病仍是0～岁组死亡的主要疾病，先天异常逐渐成为1～4岁组的第一位死因，损伤中毒和恶性肿瘤的死亡率在不同的年龄组均逐渐升高并居于5～14组死亡原因的第1～2位。     

贵州省实施妇幼卫生项目效果分析

报道５个实施妇幼卫生项目县（市）与６个非项目县（市）妇女卫生状况的调查比较。揭示实施项目工作５年来，贵州省妇幼卫生工作取得很大进展，孕产妇死亡率由实施前２３６．８／１０万降至１４９．１／１０万。其中项目县降至９６．８／１０万，非项目县降至１８１．８／１０万。新法接生率、产前检查率与产后访视率均比项目实施前有明显提高。项目工作的实施促进了项目地区基层网络与妇幼队伍的建设，提高了基层人员妇幼卫生服务的主动性，出现了新婚女性婚姻生育观念的转变。还必须深入持久地推行孕产妇系统管理，尤其是高危孕产妇的分级管理，努力提高住院分娩率，才能大幅度降低孕产妇的死亡率     

Short and long term effects of exercise training on the tonic autonomic modulation of heart rate variability after myocardial infarction

We studied the effects of cardiac rehabilitation on the sympathovagalcontrol of heart rate variability in 30 patients after a first,uncomplicated myocardial infarction. Twenty-two patients completed8 weeks of endurance training (trained), while eight decidednot to engage in the rehabilitation programme for logisticalreasons, and were taken as untrained controls. Age, site ofinfarction, ejection fraction, ventricular diameter and stresstest duration were similar in the two groups at baseline. Heartrate variability was evaluated 4 weeks after infarction beforestarting rehabilitation, and repeated 8 weeks and one year laterin both trained and untrained patients. Measures of heart ratevariability, obtained from both time- and frequency- domainanalysis of a 15 min ECG recording in resting conditions, wereas follows: mean RR interval and its standard deviation (RRSD),the mean square successive differences (MSSD), the percent ofRR intervals differing >50 ms from the preceding RR (pNTN50),the low and high frequency components of the autoregressivepower spectrum of the RR intervals and their ratio (LF/HF).At baseline, heart rate variability was similar in trained anduntrained patients. In the short term (8 weeks after infarction),training increased RRSD by 25% (P<0·01), MSSD by 69%(P<0·01), pNN50 by 120% (P<0·01), and reducedLF/HF ratio by 30% (P<0·01). The effects persistedafter one year in trained patients. In untrained patients, theautonomic control of heart rate variability did not change 8weeks after myocardial infarction and was only slightly modifiedby time. Thus, exercise training, performed for 8 weeks aftera myocardial infarction, modifies the sympathovagal controlof heart rate variability toward a persistent increase in parasympathetictone, known to be associated with a better prognosis. This maypartly account for the favourable outcome of patients who undergorehabilitation.     

上尿路结石致肾积水患者锂清除率的测定

采用原子吸收光谱法对４０例上尿路结石致肾积水患者进行了锂清除率测定。结果显示：梗阻所致肾积水患者的ＣＬｉ明显低于正常人（Ｐ〈０．００１），ＣＣｒ、ＣＮａ、Ｃｋ与正常对照组相比差异无显著意义（Ｐ〉０．０５）；并发现ＣＬｉ与肾积水程度呈负相关。认为可将ＣＬｉ作为发现梗阻性肾病早期肾功能损害的可靠指标，评价肾功能损害的程度和预后。     

Biological characteristics of newly diagnosed poor prognosis acute myelogenous leukemia

A pilot study was conducted of the biological characteristics of the leukemia cells of newly diagnosed patients with poor prognosis acute myelogenous leukemia (AML). This study included measurements of the pretherapy proliferative rate of the leukemia cells in vivo, assessment of differentiation in vivo during remission induction therapy, and the level of expression of the fms, myc, and IL1β genes in pretherapy leukemia cells. Short cell cycle times were characteristic of the best prognostic category and were associated with a rapid reduction in marrow leukemia cells in cytosine arabinoside (araC)-sensitive patients. Expression of c-fms was associated with rapid reduction in marrow leukemia cells during araC therapy and with a successful treatment outcome. Expression of the IL1β gene was associated with short remissions. These studies suggest that when compared to newly diagnosed standard prognosis AML, the leukemia of poor prognosis patients is more likely to exhibit long cell cycle times, low levels of fms expression, and is less likely to be associated with myeloid differentiation during remission induction therapy. © 1993 Wiley-Liss, Inc.     

住院精神分裂症患者自杀危险因素调查

对全国９省市９所医院１０年间住院精神分裂症自杀死亡资料分析，自杀率占住院病人总数的０．６３％，占精神分裂症总数的０．７８％，占慢性精神分裂症的０，５０％。偏执型占６５．６·％。自杀原因受幻觉妄想支配２３．８％，悲观厌世２８．６％；精神症状好转（５９．５％）和自知力恢复期（４７．６％）易自杀。自杀方式自缢（５７．１％）和服药（２３．８％）居首。男性自杀多于女性。