CT引导下125I粒子植入联合TACE治疗原发性肝癌合并门静脉癌栓的价值

目的探讨CT引导下125I粒子植入联合TACE治疗原发性肝癌合并门静脉癌栓的临床价值。方法抽取佛山南海社会福利中心康复医院放射科2010年1月～2013年10月收治的18例原发性肝癌合并门静脉癌栓患者作为研究对象,并给予6个月～2年的随访,同时结合其临床资料进行回顾性分析。结果经治疗后随访发现,18例患者中,共有14例获得有效治愈,总有效率为77.8%。结论给予原发性肝癌合并门静脉癌栓患者CT引导下125I粒子植入联合TACE治疗,能够有效保证临床治疗效果,值得推广。     

基于微粒群优化算法和支持向量机的软测量建模

在分析基本微粒群优化算法(PSO)和支持向量机(SVM)原理的基础上,采用带有末位淘汰机制的微粒群优化算法优化支持向量机的参数,建立了延迟焦化装置粗汽油干点软测量的微粒群支持向量机模型.该方法利用支持向量机结构风险最小化原则和PSO算法快速全局优化的特点,用于软测量建模.仿真实验表明:所建模型的泛化性能较好,模型具有较高的精度.     

云计算中基于进化算法的任务调度策略

任务调度是云计算的关键问题之一,它的调度策略与算法直接影响到云计算系统的性能与成本。通过研究基于粒子群算法和遗传算法的任务调度策略,提出了一种基于进化策略的PSO-CM算法。该算法通过在粒子群算法中引入遗传算法的交叉变异策略来提高粒子群算法的全局收敛效果,并且证明了PSO-CM算法是一种全局收敛算法。Matlab仿真实验表明,该算法能够达到全局收敛,且收敛速度和稳定性优于传统的调度算法。     

不同血清学检测法诊断儿童梅毒的应用研究

目的：探讨三种血清学检测方法在临床诊断儿童梅毒中的应用情况。方法选择沈阳市儿童医院2014年12月至2016年2月门诊及住院患者4230例,分别进行了以下检测：甲苯胺红不加热血清试验（ TRUST）、梅毒螺旋体抗体检测胶体金法（ SYP）、梅毒螺旋体明胶凝集试验（ TPPA）,并对检测结果进行分析。结果用三种方法对血液标本进行检测,经任意一项检测为阳性即视为阳性患者共28例。其中三项检测均为阳性4例（14．3％）,有两项检测为阳性11例（39．3％）,只有一项检测为阳性13例（46．4％）。确诊阳性患者15例。在检测中TRUST特异度（92．3％）高,但敏感度（40．0％）低;SYP敏感度（86．7％）高,但特异度（7．7％）低,均不适宜单独作为初筛检测试验。应用TRUST和SYP联合检测作为初筛试验,其中任意一种为阳性结果,灵敏度为100．0％。结论用TRUST、SYP联合作为梅毒初筛检测试验;TPPA可以用作梅毒确诊实验;TRUST适宜疗效观察。     

Study on Wear Mechanism of Helical Gear by Three-Body Abrasive Based on Impact Load

This study aimed to explore the wear characteristics and evolution mechanisms of large-scale wind power gears under the impact load of particles of the three-body abrasive Al₂O₃ (0.2 mg/mL) from four aspects: oil analysis, vibration analysis, amount of gear wear, and tooth-surface-wear profile analysis. A magnetic powder brake was used to simulate the actual working conditions. Combined with the abrasive particle monitoring and the morphology analysis of the tooth-surface-wear scar, by setting quantitative hard particles in the lubricating oil, the gears are mainly operated in the abrasive wear state, and wear monitoring and wear degree analysis are carried out for the whole life cycle of the gears. Oil samples were observed and qualitatively analyzed using a particle counter, a single ferrograph, a metallographic microscope, and a scanning electron microscope. The experiments demonstrate that the initial hard particles have a greater impact in the early wear stage of the gears (<20 h), and abrasive particle concentration increases by 30%. This means that Al₂O₃ particles accelerate the gear wear during the running-in period. The loading method of the impact load on the oblique gear exacerbates the abrasion particle wear and expands the stress concentration, which reduces the surface of large milling particles on the surface, and reduces the width of the tooth (the part above the pitch line is severely worn), which causes the gear to break into failure. The research provides help for analyzing the mechanism of abrasive wear of gears and predicting wear life.     

一种生物气溶胶旋风式分离采集装置的设计与验证

目的:设计一种生物气溶胶旋风式分离采集装置,为小粒径生物气溶胶分离采集和分析提供有效手段.方法:对经典旋风式分离采集装置结构参数进行优化,借助Fluent软件对筒体直径等关键结构参数对粒径分离效果的影响进行模拟仿真,确定生物气溶胶旋风式分离采集装置的最优结构参数,之后采用高纯铝材料制作生物气溶胶旋风式分离采集装置.采用...     

Generation of a Soluble African Horse Sickness Virus VP7 Protein Capable of Forming Core-like Particles

A unique characteristic of the African horse sickness virus (AHSV) major core protein VP7 is that it is highly insoluble, and spontaneously forms crystalline particles in AHSV-infected cells and when expressed in vitro. The aggregation of AHSV VP7 into these crystals presents many problems in AHSV vaccine development, and it is unclear whether VP7 aggregation affects AHSV assembly or contributes to AHSV pathogenesis. Here, we set out to abolish VP7 self-assembly by targeting candidate amino acid regions on the surface of the VP7 trimer via site-directed mutagenesis. It was found that the substitution of seven amino acids resulted in the complete disruption of AHSV VP7 self-assembly, which abolished the formation of VP7 crystalline particles and converted VP7 to a fully soluble protein still capable of interacting with VP3 to form core-like particles. This work provides further insight into the formation of AHSV VP7 crystalline particles and the successful development of AHSV vaccines. It also paves the way for future research by drawing comparisons with similar viral phenomena observed in human virology.     

5种中药注射液与输液配伍前后不溶性微粒变化

目的 考察5种中药注射液与葡萄糖大输液配伍后不溶性微粒数量的变化.方法 用微粒分析仪分别测定配伍前输液(5%葡萄糖注射液)及其与中药注射液(血塞通注射液、银杏达莫注射液、红花注射液、参附注射液、香丹注射液)配伍后的微粒数目,并考察配伍后不同时间测得的微粒数.结果 输液中不溶性微粒数显著多于配伍前(P<0.01或P<0.05).结论 输液与中药注射液配伍后微粒数目明显增多,在临床应用中应重视此现象,尽量避免药品不良反应的发生.     

CT引导^125Ⅰ放射粒子联合间质化疗治疗晚期非小细胞肺癌

目的 探讨CT引导^125Ⅰ放射粒子联合间质化疗治疗晚期非小细胞肺癌的临床价值,可行性和安全性。方法 回顾分析经病理证实的晚期非小细胞肺癌患者31例、33个病灶,在CT引导下植入^125Ⅰ放射性粒子,联合植入化疗粒子缓释剂中人氟安,比较治疗前及治疗后6个月肿瘤变化,判定疗效。结果 31例患者33个病灶,6个月后CT复查,CR 6例（19.4%）、PR 21例（67.7%）、NC 3例（9.7%）、PD 1例（3.2%）,有效率（CR＋PR）87.1%。术中4例出现少量气胸,1例肺内少量出血,术后1周内痰中带血丝3例。结论 CT引导^125Ⅰ放射粒子联合间质化疗治疗晚期非小细胞肺癌安全、微创、近期疗效明显。