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21.
不同致伤条件撞击对兔钝性胸部创伤伤情影响的实验研究 总被引:18,自引:5,他引:13
探讨不同致伤参数对兔钝性胸部创伤后胸部筘器官伤情的影响。方法采用兔钝性胸部创伤型,设置不同的致伤参数,观察其对胸部各器 伤情影响及其对死亡率的影响。结果驱动压力越大,胸部各器官伤情越重;撞击面积越大,对胸壁和肺的损伤较重,但心脏伤情并不随之加重;收缩末期撞击对心脏的损伤较重,舒张末期撞击大血管系统的影响较大,死亡率与驱动压力、撞击面积成正;舒张末期撞击死亡率上升。结论致伤参数不同,对钝化胸部创伤后 相似文献
22.
We determined the microviscosity of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine cerebral cortex and
liposomes of total lipids (SPMTL) and phospholipids (SPMPL) extracted from SPMV. Changes in the microviscosity induced by
the range and rate of lateral diffusion were measured by the intramolecular excimerization of 1,3-di(1-pyrenyl)-propane (Py-3-Py).
The microviscosity values of the direct probe environment in SPMV, SPMTL and SPMPL were 38.17, 31.11 and 27.64 cP, respectively,
at 37°C and the activation energies (Ea) of the excimer formation of Py-3-Py in SPMV, SPMTL and SPMPL were 8.236, 7.448 amd 7.025 kcal/mol, respectively. Probe location
was measured by polarity and polarizability parameters of the probe Py-3-Py and probe analogues, pyrene, 1-pyrenenonanol and
1-pyrenemethyl-3β-hydroxy-22,23-bisnor-5-cholenate (PMC), incorporated into membranes or solubilized in reference solvents.
There existed a good linear relationship between the first absorption peak of the1La band and the polarizability parameter (n
2−1)/(2n
2+1). The calculated refractive index values for SPMV, SPMTL and SPMPL were close to 1.50, which is higher than that of liquid
paraffin (n=1.475). The probe location was also determined by using a polarity parameter (f−1/2f1). Here f=(ε−1)/(2ε+1) is the dielectric constant function and f'=(n
2−1)/(2n
2+1) is the refractive index function. A correlation existed between the monomer fluorescence intensity ratio and the solvent
polarity parameter. The probes incorporated in SPMV, SPMTL, and SPMPL report a polarity value close to that of 1-hexanol (ε=13.29).
In conclusion, Py-3-Py is located completely inside the membrane, not in the very hydrophobic core, but displaced toward the
polar head groups of phospholipid molecules, e.g., central methylene region of aliphatic chains of phospholipid molecules. 相似文献
23.
Jonas M. Weissbrod Rakesh K. Jain Francis M. Sirotnak 《Journal of pharmacokinetics and pharmacodynamics》1978,6(6):487-503
A lumped compartmental model has been derived to predict methotrexate concentration as a function of time for L1210 cells in BD2F
1
female mice at doses ranging from 3 mg/kg to 400 mg/kg. Using standard methods of parameter estimation as well as experimental determinations, an integrated approach was derived to account for the differences between the subcutaneous (s.c.) and intraperitoneal (i.p.) modes of injection. It was found that a single generalized forcing function can be used to fit plasma concentration after s.c. injection for all doses. Adequate fits (average error<20% while the standard deviation of experimental determinations was±22%) of L1210 cell data after s.c. injection were obtained. The best results were for a maximum facilitated influx constant Vmax
of 0.424 g/min/ml, a Michaelis influx constant Km
of 1,42 g/ml, and a first-order efflux constant of 0.047 min–1.The model simulations were not sensitive to Vmax, Km,and so long as the ratio Vmax/was approximately 9g/ml. The values of V
max
,K
m
,and which were obtained from our analysis of the in vivodata can be explained on the basis of previously performed in vitroexperiments. The parameters obtained from modeling the s.c. data were then applied for i.p. injection data. The resulting fits were adequate (average error<20% while the standard deviation of experimental determinations was±22%). A single generalized forcing function for drug concentration in the peritoneal cavity after i.p. injection for all doses was derived. The application of these results enables the prediction of methotrexate concentration in neoplastic cells at other doses after either s.c. or i.p. injection. 相似文献
24.
B. C. Dunphy MD MRCOG C. L. R. Barratt R. Kay E. J. Thomas L. M. Neal and I. D. Cooke 《Andrologia》1991,23(1):35-39
Two methods of recruiting fertile male controls were evaluated and compared. The first group was recruited from the partners of women attending an antenatal clinic without obtaining details of their reproductive history. The second group was recruited after obtaining a detailed reproductive history from the couple and employing stringent entry criteria. Entry criteria for the second group included a length of exposure to the risk of pregnancy of not more than 12 months and no previous episode of involuntary infertility for either partner. There were significant differences between the distributions of semen parameters obtained from the two groups, indicating that the selection criteria for "fertile" men significantly influence results obtained and therefore that it is important to employ stringent criteria for the recruitment of fertile male controls. The group which was recruited by stringent criteria (mean length of exposure to the risk of pregnancy of 3 months) was characterised by a significantly higher median concentration of spermatozoa which exhibited slow linear or nonlinear motility. This confirms the findings of a previous study which suggested that slow linear or nonlinear motility are superior forms of spermatozoal motion. 相似文献
25.
26.
程汉平 《安徽卫生职业技术学院学报》2004,3(3):71-73
该文给出了一类分布族为单调似然比分布族的条件,从而可知非中心的分布族和非中心的分布族均为单调似然比分布族. 相似文献
27.
Varlet P Guillamo JS Nataf F Koziak M Beuvon F Daumas-Duport C 《Neuropathology and applied neurobiology》2000,26(4):379-389
Microangiogenesis is a delayed but crucial event in the malignant progression of oligodendrogliomas. Accord-ingly, in the new Sainte-Anne grading system of oligodendrogliomas, endothelial hyperplasia and contrast enhancement, both being indicators of microangiogenesis, are key criteria for the distinction of grade A from grade B tumours. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor: a strong correlation between VEGF expression, Sainte-Anne malignancy grade and patient outcome might thus be expected. In order to assess this hypothesis, VEGF immunostaining was performed in a series of 34 oligodendrogliomas that included 11 grade B and 23 grade A, of which nine became grade B during the study period (mean clinical and imaging follow-up: 41 months). VEGF expression correlated strongly with Sainte-Anne tumour grade (P < 0.001), and inversely with patient survival (P < 0.001) and recurrence-free survival (P = 0.002). One hundred per cent of grade B but only 17% of grade A were VEGF-positive. By contrast, the MIB-1 labelling index did not correlate with VEGF expression, total survival or recurrence-free survival. In accordance with the grading system, this study showed that, in oligodendrogliomas, VEGF expression and microangiogenesis are progression-related phenomena that confer on these tumours a growth advantage by presumably reducing hypoxia-induced apoptotic cell death. These findings might have important implications in the future for the indication and timing of anti-angiogenic therapies. 相似文献
28.
Tadeusz agoda Sabrina Vantadori Karolina Gowacka Marta Kurek Krzysztof Kluger 《Materials》2022,15(10)
The Smith-Watson-Topper parameter (SWT) in its original form was designed to estimate the fatigue life of metal materials in a uniaxial load state (tension–compression) in the range up to fatigue crack initiation, with non-zero mean values. This parameter is based on the analysis of both stress and strain. Therefore, the stress–strain criterion is the focus, rather than the energy criterion. This paper presents the original SWT model and its numerous modifications. The first part presents different versions of this parameter defined by the normal parameters. Then, it presents versions defined through the tangent parameter and the most promising parameter defined through the tangent and normal parameters. It was noted that the final form of the equivalent value is defined either by stress or by an energy parameter. Therefore, the possible characteristics from which the fatigue life can be determined are also presented. 相似文献
29.
30.
目的探讨光学相干断层扫描仪(optical coherence tomography,OCT)测量视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度及视盘参数在青光眼早期诊断中的应用及意义。方法青光眼患者120例(192眼)分为早期青光眼组42例(66眼)、中期青光眼组46例(76眼)和晚期青光眼组32例(50眼),另设正常对照组50例(82眼),均采用Topcon 3D OCT检测RNFL厚度和视盘参数,计算各个参数的受试者工作特征曲线下面积(are aunder the receiver operating characteristi ccurve,AROC),并对检测结果进行比较分析。结果正常对照组、早期青光眼组、中期青光眼组和晚期青光眼组的平均RNFL厚度分别为(112.31±9.34)μm、(105.45±6.74)μm、(82.19±7.28)μm、(52.48±7.85)μm;与正常对照组比较,各青光眼组的RNFL厚度差异均有显著统计学意义(均为P<0.01);各青光眼组之间两两比较差异也均有显著统计学意义(均为P<0.01)。与正常对照组相比,各青光眼组的视盘面积无明显变化,差异均无统计学意义(均为P>0.05),而视杯面积、视杯容积、杯盘比、水平杯盘比和垂直杯盘比均显著增加,差异均有显著统计学意义(均为P<0.01);盘沿面积和盘沿容积均显著降低,差异均有显著统计学意义(均为P<0.01);各青光眼组间除视盘面积外,各参数差异也均有显著统计学意义(均为P<0.01)。在正常对照组与早期青光眼组和全部青光眼组之间,对于RNFL厚度来说,平均RNFL厚度的AROC值最大;对于视盘参数来说,杯盘比的AROC值最大。结论 RNFL厚度和视盘参数是早期诊断青光眼的敏感指标,OCT检测RNFL厚度和视盘参数有助于青光眼的早期诊断。 相似文献