太渊穴自发红外辐射光谱研究

为研究穴位自发红外辐射特性，采用自制高灵敏度PHE201体裹红外光谱仪检测47名健康成年人和50名冠心病患者太渊穴1．5-16μm波段自发红外辐射光谱。结果：冠心病患者与正常人太渊穴自发红外辐射光谱形态基本相似，其峰值相位不存在统计学差异；在某些波段，冠心病患者的红外辐射强度与正常人的相比有显着差异。结论：冠心病患者心脏病理信息在太渊穴红外辐射特性上的反映主要是某些特定波段红外辐射强度的变化。     

出生缺陷与电磁辐射和食物链关系分析

目的探讨出生缺陷与电磁辐射和食物链的关系。方法选择195例出生缺陷患儿母亲作为研究组,195例健康儿母亲为对照组,对两组孕期居住环境及使用手机、电脑、电磁炉、微波炉频率和饮食习惯等进行调查,并检测分娩时母血雌激素、孕酮、睾酮水平。结果研究组居住靠近变压器、电视塔、通讯转播塔比例高于对照组（P均〈0.05）,孕期食用人工饲料喂养的家禽、牲畜、鱼等的频率高于对照组（P均〈0.05）;研究组孕期使用手机、电脑、电磁炉、微波炉、观看电视的频率高于对照组（P均〈0.05）。结论电磁辐射和食用人工饲料喂养的家禽、牲畜、鱼类等肉食对出生缺陷可能有影响。     

立体定向适形放射治疗肺癌的临床观察

目的观察立体定向适形放射治疗肺癌疗效和副反应。方法研究组采用立体定向适形放疗技术对40例Ⅰ-Ⅳ期肺癌病人进行治疗,单次靶区周边处方剂量2-6Gy,每周3-5次,总量60-72Gy;对照组采用常规放射治疗肺癌病人40例,DT1.8-2Gy/次,1次/天,总量60-70Gy;比较两组治疗后疗效、临床症状改善和不良反应。结果研究组治疗有效(CR PR)35例,占87.5%,其中CR8例占20%,PR27例占68%,临床症状改善率96.7%,放疗副反应发生率为13.5%;对照组:治疗有效(CR PR)31例,占77.5%,其中CR3例占7.5%,PR28例占70%,临床症状改善率为81.63%,放疗副反应发生率为25%。两组对比,研究组有效率高于对照组,但P>0.05无统计学意义。临床症状改善率研究组高于对照组,P<0.05,有统计学意义。放疗副反应发生率研究组明显低于对照组,P<0.001,有显著性差异。结论立体定向适形放射治疗肺癌有较好的近期疗效和症状改善率,与传统的常规放疗方法比较副反应明显减轻,患者易耐受,是一种有效、安全的治疗肺癌新的放疗方法。     

鼻咽癌放疗性角膜损伤的跟踪研究

目的:探讨鼻咽癌(NPC)放射治疗眼部并发症。方法:对 213 例 NPC 初程放疗患者进行跟踪观察。放疗前、放疗中及放疗后作视功能(包括远视力、裂隙灯活体显微镜、眼底、自动电脑视野及视诱发电位)检查和角膜荧光素染色。结果:发生角膜损伤 19 例,占 8.9 %(19/213)。I～Ⅱ期6 例,Ⅲ期 8 例,Ⅳ期 5 例。全部发病患者均无角膜刺激症状,放疗后 10mo 内,角膜病变消退,但知觉仍较对侧眼明显减退;20mo 后尚未恢复正常。未发现晶状体混浊的患者。结论:NPC 放疗性角膜损伤与鼻咽癌临床分期及照射剂量无密切关系(P>0.05),可能主要与角膜感觉神经损伤导致眼表疾病密切相关;不排除患者不同个体对辐射的敏感差异性。     

Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy Patients

There has been an increasing interest in patient-reported outcome (PRO) measures in both the clinical and research settings to improve the quality of life among patients and to identify when clinical intervention may be needed. The primary purpose of this prospective study was to validate an acute breast skin toxicity PRO measure across a broad sample of patient body types undergoing radiation therapy. Between August 2018 and September 2019, 134 women undergoing adjuvant breast radiotherapy (RT) consented to completing serial PRO measures both during and post-RT treatment and to having their skin assessed by trained trial radiation therapists. There was high patient compliance, with 124 patients (92.5%) returning to the clinic post-RT for at least one staff skin assessment. Rates of moist desquamation (MD) in the infra-mammary fold (IMF) by PRO were compared with skin assessments completed by trial radiation therapists. There was high sensitivity (86.5%) and good specificity (79.4%) between PRO and staff-reported presence of MD in the IMF, and there was a moderate correlation between the peak severity of the MD reported by PRO and assessed by staff (rho = 0.61, p < 0.001). This prospective study validates a new PRO measure to monitor the presence of MD in the IMF among women receiving breast RT.     

X-ray Fluorescence Analysis of Pigments in Gothic Frescoes,Coats of Arms,and Polychromy on Sculptures on the Triforium in St. Vitus Cathedral on the Territory of the Czech Kingdom in the 14th Century

Pigments in the paints used for the coats of arms, polychromy on sculptures, and pigments in frescoes characterize not only the epoch but also individual creators or groups of artists involved in their creation. X-ray fluorescence analysis is a non-destructive method suitable for determining the chemical composition of these artifacts. This article covers the results of measurements of selected objects, and compares them with similar objects from the territory of the Czech Kingdom in the 14th century.     

阿魏酸及衍生物对γ射线照射小鼠活存率的影响

目的检测阿魏酸系列衍生物对8.5 Gy照射小鼠活存率的影响,以确定候选化合物。方法 ICR小鼠分为模型组、阳性药WR2721组、茜草双酯片组、阿魏酸、阿魏酸钠、5-溴阿魏酸及5-溴阿魏酸钠4种受试药高、中、低剂量组。观察药物对8.5 Gy照射小鼠活存率和死亡鼠平均活存时间的影响。结果照射对照组动物在14 d内全部死亡,阿魏酸系列衍生物可以显著提高8.5 Gy照射小鼠活存率,延长死亡鼠平均活存时间。结论阿魏酸钠对8.5 Gy照射小鼠活存效果较好,可考虑作为抗辐射药物做进一步研究。     

Validation of Adult Relative Radiation Levels Using the ACR Dose Index Registry: Report of the ACR Appropriateness Criteria Radiation Exposure Subcommittee

The ACR Dose Index Registry (DIR) provides a new source of clinical radiation exposure data that has not been used previously to establish or update the relative radiation level (RRL) values in the ACR Appropriateness Criteria (AC). The results of a recent review of DIR data for 10 common CT examinations were compared with current ACR AC RRL values for the same procedures. The AC RRL values were previously determined by consensus of members of the AC Radiation Exposure Subcommittee based on reference radiation dose values from the literature (when available) and anecdotal information from individual members’ clinical practices and experiences. For 7 of the 10 examination types reviewed, DIR data agreed with existing RRL values. For 3 of 10 examination types, DIR data reflected lower dose values than currently rated in the AC. The Radiation Exposure Subcommittee will revise these RRL assignments in a forthcoming update to the AC (in October 2018) and will continue to monitor the DIR and associated reviews and analyses to refine RRL assignments for additional examination types. Given recent attention and efforts to reduce radiation exposure in CT and other imaging modalities, it is likely that other examination types will require revision of RRL assignments once information from the DIR database is considered.     

1H磁共振波谱对脑胶质瘤放疗术后应用价值

目的 探讨^1H磁共振波谱（^1H MRS）对脑胶质瘤放疗后疗效监测和预后评估的应用价值。方法 10例经手术病理或临床证实的脑胶质瘤患者，接受40-500y的脑部放射治疗，随访进行^1H MRS检查和磁共振检查。结果 放疗后3-6个月治疗有效3例，^1H MRS表现为Cho下降或明显下降，Cho/Cr明显升高；放疗后1年以上肿瘤放射坏死6例中。NAA、Cr\Cho明显降低或消失，1例2年后肿瘤复发出现明显升高的Cho峰。结论 ^1H MRS可以作为临床监测放疗疗效和评估预后的一种手段。     

益气养阴法为主治疗放射性口咽黏膜损伤

气阴两虚是放射性口咽黏膜损伤发生、发展的重要病机,治疗时将益气养阴法贯穿于治疗始末,并配合其他治法能有效减轻患者的痛苦,修复并调节唾液腺,改善局部微循环,促进微血管及组织的修复愈合,提高患者的生活质量.