蜂房提取物抑制H22小鼠移植瘤增殖的作用研究

[目的]探讨蜂房提取物对小鼠H22肿瘤细胞生长的影响及其抑瘤作用机制。[方法]将40只小鼠随机分为盐水对照组、氟尿嘧啶组、蜂房高剂量组和蜂房低剂量组,每组10只。测定荷瘤小鼠的瘤质量和抑瘤率,观察蜂房提取物对肿瘤生长的影响,同时采用免疫组化方法检测瘤组织中C-Met的表达。[结果]蜂房高、低剂量组的抑瘤率分别为31.96%、27.84%,与盐水对照组比较差异有统计学意义(P<0.01);C-Met在4组中均呈阳性表达,与盐水对照组比较,蜂房高、低剂量组C-Met的表达减弱,差异有统计学意义(P<0.05)。[结论]蜂房提取物对小鼠H22移植性实体瘤有明显的抑制作用,其机制可能与降低肝癌细胞内C-Met的表达有关。     

病人可视化索引系统的设计与实现

为了全面完整地了解一位病人的医疗状况,医生需要从不同的医学信息系统（如PACS,RIS,HIS,USIS）中搜寻病人医疗报告,作为对病人进行诊断和治疗的决策参考,但是这部分工作非常耗时与冗长乏味。为此开发了一套病人可视化索引系统,利用可视化技术在3D人体模型上显示病人全面的健康状况,为保存在各个系统中的病人检查信息提供检索功能。     

Arteriovenous malformation at the cervicomedullary junction: A case report with magnetic resonance imaging

A rare case of arteriovenous malformation at the cervicomedullary junction is reported. A 72-year-old man developed symptoms of total transection of the upper cervical cord without evidence of subarachnoid hemorrhage. The arteriovenous malformation had an intramedullary nidus with an aneurysmal dilatation at the C-1 level. This lesion was diagnosed by magnetic resonance imaging and confirmed at autopsy. The neurological symptoms may have been due to compression of the spinal cord by the intramedullary lesion, followed by degeneration and necrosis. The usefulness of magnetic resonance imaging in the neuroradiological diagnosis is particularly emphasized.     

淮河水系东方次睾吸虫自然疫源地调查

本文报道东方次睾吸虫可在纹沼螺、麦穗鱼和雏鸭体内完成生活史。淮河水系是东方次睾吸虫的自然疫源地。     

Osteoid osteoma with a multicentric nidus: a case report and review of the literature

To date, 23 cases with osteoid osteoma (OO) including multiple nidi in single bone have been reported in the world literature. A case report of an 18-year-old boy with an OO on his left femoral neck, which contained double nidi is presented. Plain radiography, computed tomography (CT) and magnetic resonance imaging (MRI) of the proximal femur showed OO with a multicentric nidus. Bone scintigraphy demonstrated increased activity in the left femoral neck region. The tumor was removed with curettage and shaving using lateral approach. The patient was asymptomatic for 5 years after surgery.     

Congested residual nidus after preoperative intranidal embolization in midsize cerebral arteriovenous malformations of 3–6 cm in diameter

Summary Background. Modern delicate microcatheters allow intranidal embolization of cerebral arteriovenous malformations (AVM). The aim of the current analysis was to assess effects of preoperative intranidal deployment of embolic material on surgical time and blood loss in cerebral arteriovenous malformations of 3–6cm in diameter. Methods. The case records of 38 cerebral AVM between 3 and 6cm in maximum diameter were reviewed, that had been embolized intranidally with N-butyl 2-cyanoacrylate (Histacryl) and subsequently operated on. Surgical time and blood loss as well as particular intraoperative findings such as a congested nidus and thrombosis of draining veins were registered and correlated with the extent of embolization and the time interval between embolization and surgery. Findings. Preoperative embolization occluded an estimated range of 10 to 90% of the nidus. Minor embolization related bleeding without clinical relevance occurred in 5 patients. Significant embolization related bleeding resulting in earlier than planned surgery occurred in another 5 patients. All embolization related haemorrhages occurred within 24 hours. Average total operating time was 343±106min and average blood loss was 684±858ml. Unequivocal bleeding difficulty from the nidus and a total blood loss of more than 1000ml were encountered in 7 instances and dissection was tedious due to a bleeding AVM core in 5 other cases. A congested AVM core was the source of bleeding in 11 patients and paraventricular neovascularization in one. 6 of the 11 cases with a congested AVM core had suffered minor or substantial haemorrhage after a preoperative endovascular procedure. Intraoperative nidus congestion was noted in this series after an interval as long as 2 weeks after the last embolization. Combined management resulted in permanent morbidity in 6 of the 38 cases. In 4 of them the neurological deficit was associated with an intraoperative bleeding problem, in all due to congested nidus. Morbidity had to be correlated with major haemorrhage resulting from preoperative embolization in 2 instances. Conclusions. Intranidal embolization prior to surgical removal of AVM can lead to a congested residual nidus and intraoperative bleeding. Minor leakage after preoperative embolization is an inconsistent warning sign of nidus congestion. Nidus outflow after intranidal embolization appears to require a few weeks for normalization. Delay of surgery after embolization should be considered in cases of suspected congested residual nidus. The danger of major haemorrhage or arterial revascularization during this waiting period appears small.     

淮南地区宫川棘口吸虫自然疫源地调查

目的 了解淮南地区宫川棘口吸虫自然疫源地情况.方法 调查淮南洛河、窑河、高溏湖和焦岗湖4水域的家鸭和淡水螺类,收集家鸭粪便并用改良厚涂片法查找宫川棘口吸虫卵;取静水椎实螺经压片、镜检,分离雷蚴、尾蚴和囊蚴,并将分离获得的囊蚴感染雏鸭;解剖购自渔民的家鸭和人工感染的雏鸭,取肠管分离成虫.结果 家鸭粪便中宫川棘口吸虫卵检出率为19.50％(39/200);静水椎实螺中雷蚴、尾蚴检出率为1.63％(13/800),囊蚴检出率为6.63％ (53/800);家鸭肠管内成虫的检出率为21.67％(13/60),经囊蚴感染的雏鸭肠管内可分离出成虫.结论 淮南地区存在宫川棘口吸虫自然疫源地,其生活史可在静水椎实螺和雏鸭体内完成.