DNA Strand Breaks from Tritium Decay: A Local Effect for Cytosine-6-3H

Summary

Twelve-week-old female (C3H × 101)F₁ mice were injected intravenously with an ultrafiltered solution of ²³⁹Pu in 1 per cent trisodium citrate, and mated to uninjected PCT males. The plutonium content was examined radiochemically and autoradiographically in placentae and foetuses on the 12th and 18th days of gestation, and in neonates during the 24 hours after birth and also at 18 days post-natally.

Plutonium was distributed in most tissues of the late foetus and the suckling as it is in adult mice. However, on both the 12th and 18th days of gestation the concentration in the yolk-sac splanchnopleure was much higher than in any other foetal tissue. The amount of ²³⁹Pu in 18-day-old sucklings was between two and seven times as great as in 1-day-old neonates because of ingestion of milk from the lactating dams. In the first litter following administration of the radionuclide to the dam, about 0·02 per cent of the plutonium injected was transferred to an individual offspring by the time of birth, and a further 0·08 per cent by the time of weaning.     

Two UV-induced episodes of myelitis in a patient with systemic lupus erythematosus.

Two flares of acute myelitis were observed in a 31-year-old woman with previously known mild SLE. The two myelitic episodes both occurred within 1 week after intense sun exposure, and for this reason photobiological induction of the manifestation is considered likely. The diagnostic utility of MRI in the acute situation and the possible influence of sex-steroids on SLE manifestations are also illustrated by this case.     

王任之“开魄门”治疗急性脊髓炎经验

王任之出身于医学世家,为新安王氏医学第五代传人,毕生行医五十余载,学识广博、经验丰富,临床治疗各科疑难杂症,疗效确切。《王任之医案》由后世整理而成,体现了王任之丰富的学术思想和临床经验。本文归纳和分析《王任之医案》中所载急性脊髓炎医案,阐述其辨治特色,从病因病机、治疗大法、遣方用药三个角度论述其辨治思想,并佐案例验证,对现代临床治疗急性脊髓炎有借鉴和启发作用。     

放射性脊髓炎的MRI诊断及综合康复治疗观察

目的 :探讨放射性脊髓炎的MRI表现特点及临床综合康复治疗的疗效。方法 :本组 14例中 ,鼻咽癌 6例 ,骨转移癌 3例 ,其他 5例。检查采用GE 0 .5TMR扫描仪。治疗急性期采用大剂量激素冲击疗法及综合治疗 ,恢复期采用康复治疗。结果 :14例中 ,颈髓 10例 ,胸髓 4例。急性期MRI表现为放射野内大片状边缘模糊的略长T1长T2 异常信号 ,脊髓增粗 8例 ,边缘不规整 3例。治疗后症状完全缓解 6例 ,部分缓解 4例。结论 :MRI是诊断放射性脊髓炎的可靠方法 ;对放射性脊髓炎应积极采取综合康复治疗。     

Acute Flaccid Myelitis: A Clinical Overview for 2019

Acute flaccid myelitis (AFM) is characterized by flaccid paralysis of one or more limbs, often following a viral illness, with magnetic resonance imaging findings consistent with inflammation of the spinal cord gray matter. It is unclear whether all patients with AFM will have full recovery of neurologic function. Since 2014, there have been several clusters of AFM in the United States, with a 3-fold increase in reported AFM cases recorded in 2018 compared with the previous year. Epidemiological evidence supports a temporal association between respiratory enteroviral illness, particularly with enteroviruses D68 and A71, and clustering of AFM cases. However, causality has yet to be established. Treatment of AFM is primarily supportive. Adjunctive therapies such as intravenous immunoglobulin, corticosteroids, plasmapheresis, and fluoxetine have not been found to improve long-term outcomes. Further research is urgently needed to characterize and optimize management of this emerging, yet poorly understood, condition.