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991.
Marisa H. Sellinger Robert M. Hodapp Elisabeth M. Dykens 《Journal of developmental and physical disabilities》2006,18(1):59-71
This study extends laboratory-based profiles to participation in leisure activities for persons with three genetic syndromes. Parents of 223 persons with Prader-Willi, Williams, and Down syndromes filled out a newly developed Leisure Activities Questionnaire. Sixteen items loaded onto five distinct factors: social; visual-spatial; visual-strategy; musical; and physical activities. Individuals with Williams syndrome less often participated in visual-spatial activities, those with Prader-Willi syndrome more often performed both visual-spatial and visual-strategy activities, and those with Williams and Down syndromes more often performed musical activities. With increasing chronological ages, all groups increased in their social activities, while those with Williams and Down syndromes decreased in their visual-spatial activities. In both Prader-Willi and Williams syndrome, decreased maladaptive behaviors related to greater amounts of participation in etiology-related activities. Theoretical and practical implications are discussed. 相似文献
992.
晚期肺癌的中医证候研究 总被引:18,自引:0,他引:18
目的 探讨晚期肺癌的主要中医证候。方法 采用回顾性与前瞻性相结合的方法进行临床观察。结果 经 χ2 检验 ,不同中医证候的晚期肺癌组之间有显著性差异 (P <0 0 1) ,而血瘀证、气虚证、痰证、阴虚证最为多见 ;晚期非小细胞肺癌与晚期小细胞肺癌的中医证型没有显著性差异。结论 晚期肺癌的中医证候以血瘀证、气虚证、痰证、阴虚证为主 ;晚期非小细胞肺癌与小细胞肺癌的中医证候无明显差异。 相似文献
993.
Eun-Jung Choi Byung-Duk Ahn Jae-Il Lee Jung-Wook Kim 《Journal of oral pathology & medicine》2007,36(4):250-251
We report a case of rare multiple internal resorptions. Etiology of multiple internal resorptions is unknown. Interestingly, the patient had an atopic dermatitis, which is possibly related to multiple and rapid internal resorptions. 相似文献
994.
Etienne Pralong Claudio Pollo Jean-Guy Villemure Damien Debatisse 《Movement disorders》2007,22(13):1879-1884
Besides clinical efficacy, the mechanisms of action of deep brain stimulation (DBS) are still debated. To shed light on this complex issue, we have taken the opportunity to record the response of globus pallidus internus (GPi) neurones to 100 Hz stimulations in a case of Lesch-Nyhan syndrome (LNS) where four pallidal electrodes were implanted. Three types of response were observed, 2/19 neurones were unaffected by DBS. About 7/19 neurones were inhibited during DBS stimulation and 10/19 neurones were excited during DBS stimulation. Both effects ceased when DBS was turned off. Inhibited neurones were situated lower that exited ones on the trajectory (1.25 and 4.65 mm above the center of GPi respectively). These observations suggest that locally DBS induces a reversible inhibition of neurone firing rate while at the same time distantly exciting the main afferents to and/or efferents from the GPi. Both actions would result in a strong GPi inhibition that does not preclude increased outflow from the GPi. 相似文献
995.
目的探讨Tourette综合征(TS)患儿体感诱发电位(SEP)变化特征及其对脑功能损害程度及定位诊断的价值。方法对76例TS患儿(TS组)、20例精神发育迟滞(MR)患儿(MR组)和22例健康儿童(正常对照组)进行SEP检测,观察各组各波的潜伏期和形态改变。结果与正常对照组儿童相比,TS组N2、P3、N3波潜伏期延长,MR组P2、N2、P3波潜伏期延长,但均无显著性差异(P均>0.05);TS组和MR组与正常对照组儿童比较,N2、P3、N3波有缺失现象,差异有显著性意义(P均<0.01)。TS与MR组患儿的波形缺失均以右侧为甚,但两侧比较差异无显著意义(P>0.05)。结论TS患儿存在皮层及皮下脑功能损害,体感诱发电位可作为TS的辅助诊断指标。 相似文献
996.
997.
Liver and intestine transplantation 总被引:1,自引:0,他引:1
Robert S. Brown Sarah H. Rush Hugo R. Rosen Alan N. Langnas Goran B. Klintmalm Douglas W. Hanto Jeffrey D. Punch 《American journal of transplantation》2004,4(S9):81-92
The most significant development in liver transplantation in the USA over the past year was the full implementation of the MELD- and PELD-based allocation policy in March 2002, which shifted emphasis from waiting time within broad medical urgency status to prioritization by risk of waiting list death. The implementation of this system has led to a decrease in pretransplant mortality without increasing post-transplant mortality, despite a higher severity of illness at the time of transplant.
The trend over the last few years of rapidly increasing numbers of adult living donor liver transplants was reversed in 2002 by a decline of more than 30% in the number of these procedures. In 2002, a greater percentage of women received livers from living donors (43%) than deceased donors (34%), possibly because of size considerations.
From 1993 to 2001, the waiting list increased more than sixfold, from 2902 patients to 18 047 patients. For the first time since 1993, the waiting list size decreased in 2002, dropping 6% to 16 974 candidates. The percentage of temporarily inactive liver candidates also increased from 2001, thus the net decrease in the active waiting list for 2002 was 12%. This may reflect a trend toward less pre-emptive listing practices under MELD.
Intestine transplantation remains a low-volume procedure limited to a few transplant centers and is still accompanied by significant pre- and post-transplantation risks. As this procedure matures, its application may increase to include recipients at an earlier stage of their disease with better likelihood of success. 相似文献
The trend over the last few years of rapidly increasing numbers of adult living donor liver transplants was reversed in 2002 by a decline of more than 30% in the number of these procedures. In 2002, a greater percentage of women received livers from living donors (43%) than deceased donors (34%), possibly because of size considerations.
From 1993 to 2001, the waiting list increased more than sixfold, from 2902 patients to 18 047 patients. For the first time since 1993, the waiting list size decreased in 2002, dropping 6% to 16 974 candidates. The percentage of temporarily inactive liver candidates also increased from 2001, thus the net decrease in the active waiting list for 2002 was 12%. This may reflect a trend toward less pre-emptive listing practices under MELD.
Intestine transplantation remains a low-volume procedure limited to a few transplant centers and is still accompanied by significant pre- and post-transplantation risks. As this procedure matures, its application may increase to include recipients at an earlier stage of their disease with better likelihood of success. 相似文献
998.
We report a case of Noonan syndrome associated with central giant cell granuloma. The patient was a 101/2-year-old boy with the chief complaint of proptosis of the right eye. He also had various malformations such as short stature, webbed neck, pectus excavatum, cubitus valgus, pulmonary valve stenosis and patent foramen ovale, a characteristic face appearance and cryptorchidism and so on. Chromosome analysis showed a 46, XY karyotype. A computed tomographic scan and magnetic resonance imaging showed a mass originated from the lateral wall of the right maxillary sinus. The patient underwent Caldwell-Luc operation. Histological examination of the mass showed the characteristics of central giant cell granuloma. This case report describes a patient with the features of the recently described Noonan-like/multiple giant cell lesion syndrome. 相似文献
999.
目的:探讨以脑立体定向术治疗震颤麻痹、癫痫、癌性疼痛、慢性精神病及颅内金属异物的方法和疗效。方法:用多功能脑立体定向仪对不同疾病毁损其不同的核团。结果:震颤麻痹166例共182次手术中治愈13例次,显效145例次,有效11例次,无效12例次,死亡1例,有效率达929%;癫痫18例,显效11例,有效4例,无效3例,有效率达833%;癌性痛疼5例均显效;精神病3例,显效2例,有效1例;颅内异物2例均治愈。结论:脑立体定向术对以上疾病均取得了较为满意及良好的疗效,总有效率达924%,并且比传统开颅术简便安全 相似文献
1000.
J. E NAGTEGAAL G. A KERKHOF M. G SMITS SWART & Y. G VAN DER MEER 《Journal of sleep research》1998,7(2):135-143
In a double-blind placebo-controlled cross-over study, 30 patients with Delayed Sleep Phase Syndrome (DSPS) were included, of whom 25 finished the study. Melatonin 5 mg was administered during two weeks in a double-blind setting and two weeks in an open setting successively or interrupted by two weeks of placebo. The study's impact was assessed by measurements of the 24-h curves of endogenous melatonin production and rectal temperature (n=14), polysomnography (n=22), actigraphy (n=13), sleep log (n=22), and subjective sleep quality (n=25). Mean dim light melatonin onset (DLMO) (±SD), before treatment, occurred at 23.17 hours (±138 min). Melatonin was administered five hours before the individual DLMO. After treatment, the onset of the nocturnal melatonin profile was significantly advanced by approximately 1.5 hour. Body temperature trough did not advance significantly. During melatonin use, actigraphy showed a significant advance of sleep onset and polysomnography, a significant decreased sleep latency. Sleep architecture was not influenced. During melatonin treatment patients felt significantly more refreshed in the morning. These results show that analysis of DLMO of patients suffering from DSPS is important both for diagnosis and therapy. These results are discussed in terms of the biochemistry of the pineal. 相似文献