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121.
M. Bina Possatto E.C. de Ataíde C.A. Fazzio Escanhoela T. Sevá-Pereira R. de Cassia Martins Alves da Silva H. Felicio L.R. de Navarro Amado R. Ferreira da Silva A. Soares Lima I.F.S.F. Boin 《Transplantation proceedings》2017,49(4):863-866
Background
Liver transplantation (LT) is a curative treatment option for hepatocellular carcinoma (HCC); recurrent HCC after liver transplantation (HCC-R) is diagnosed in 9%–16%. The objective of this study was to evaluate which factors are associated with R-HCC after liver transplantation.Methods
This retrospective real-life study analyzed 278 LTs from 3 reference centers (2,093 LTs) in Brazil from 1988 to 2015. HCC-R with histologic confirmation was seen in 40 patients (14.4%).Results
Most of them were male with cirrhosis secondary to viral hepatitis. Only 37.5% underwent chemoembolization, and 50% had cold ischemia time >8 hours. From the explant analysis, most of the patients were outside Milan criteria and 37.5% had microvascular invasion. The donors were mostly male, and the median intensive care unit time was >3 days. The Kaplan-Meier survival was lower according to alpha-fetoprotein (AFP) >200 ng/dL (P = .02), and older donors and more blood transfusions were risk factors for HCC-R death.Conclusion
AFP >200 ng/mL was associated with lower survival, and older donors and more blood transfusions were risk factors for death after HCC-R. A trend to lower survival was observed in patients who did not have chemoembolization and had cold ischemia times >8 hours. 相似文献122.
目的 探讨血清microRNA-184(miR-184)和microRNA-20a(miR-20a)联合检测对胃癌诊断的临床价值。方法 分别选取孝感中心医院332例及368例经病理确诊为慢性胃炎和胃癌的患者。采用荧光定量PCR检测所有患者血清miR-20a与miR-184的表达水平。绘制受试者工作特征(ROC)曲线,评价2种miRNA诊断胃癌的效能。根据ROC曲线确定这2种miRNA诊断胃癌的阈值,计算敏感性和特异性,并对比癌胚抗原(CEA)的测定结果。结果 慢性胃炎组患者血清miR-20a水平较胃癌组患者低(P <0.05);慢性胃炎组患者血清miR-184水平较胃癌组患者高(P <0.05)。临床病理特征中,胃癌患者血清miR-20a表达水平与临床分期、淋巴结转移、饮酒史、年龄及性别差异无统计学意义(P >0.05);胃癌患者血清miR-184表达水平与患者淋巴结转移、饮酒史、年龄及性别差异无统计学意义(P >0.05),与肿瘤临床分期有差异(P <0.05)。Logistic回归分析结果显示,血清miR-20a[R=1.012(95% CI:1.697,6.875)]、miR-184[R=2.056(95% CI:0.417,0.722)]表达水平与胃癌的发生相关(P <0.05)。经ROC曲线分析表明,诊断胃癌采用血清miR-20a的临界值为4.24,曲线下面积(AUC)为0.762,特异性为71.7%,敏感性为79.4%;miR-184临界值为10.35,AUC为0.861,特异性为82.8%,敏感性为88.4%;CEA临界值为6 mg/ml,AUC为0.740,特异性为71.4%,敏感性为69.3%;血清miR-20a、miR-184联合诊断胃癌的AUC为0.908,特异性为87.6%,敏感性为84.7%。血清miR-184和miR-20a联合诊断胃癌的AUC、特异性及敏感性较3种单一检测方法大或高。结论 采用血清miR-20a和miR-184联合检测方法诊断胃癌,临床具有一定的应用价值。 相似文献
123.
BACKGROUND AND PURPOSE The endocannabinoid 2-arachidonoylglycerol (2-AG) is degraded primarily by monoacylglycerol lipase (MGL). We compared peripheral antinociceptive effects of JZL184, a novel irreversible MGL inhibitor, with the reversible MGL-preferring inhibitor URB602 and exogenous 2-AG in rats. EXPERIMENTAL APPROACH Nociception in the formalin test was assessed in groups receiving dorsal paw injections of vehicle, JZL184 (0.001-300 μg), URB602 (0.001-600 μg), 2-AG (ED(50)), 2-AG + JZL184 (at their ED(50)), 2-AG + URB602 (at their ED(50)), AM251 (80 μg), AM251 + JZL184 (10 μg), AM630 (25 μg) or AM630 + JZL184 (10 μg). Effects of MGL inhibitors on endocannabinoid accumulation and on activities of endocannabinoid-metabolizing enzymes were assessed. KEY RESULTS Intra-paw administration of JZL184, URB602 and 2-AG suppressed early and late phases of formalin pain. JZL184 and URB602 acted through a common mechanism. JZL184 (ED(50) Phase 1: 0.06 ± 0.028; Phase 2: 0.03 ± 0.011 μg) produced greater antinociception than URB602 (ED(50) Phase 1: 120 ± 51.3; Phase 2: 66 ± 23.9 μg) or 2-AG. Both MGL inhibitors produced additive antinociceptive effects when combined with 2-AG. Antinociceptive effects of JZL184, like those of URB602, were blocked by cannabinoid receptor 1 (CB(1)) and cannabinoid receptor 2 (CB(2)) antagonists. JZL184 suppressed MGL but not fatty-acid amide hydrolase or N-arachidonoyl-phosphatidylethanolamine phospholipase D activities ex vivo. URB602 increased hind paw 2-AG without altering anandamide levels. CONCLUSIONS AND IMPLICATIONS MGL inhibitors suppressed formalin-induced pain through peripheral CB(1) and CB(2) receptor mechanisms. MGL inhibition increased paw skin 2-AG accumulation to mediate these effects. MGL represents a target for the treatment of inflammatory pain. 相似文献
124.
J. Catano A. Guedon S. Riviere F. Carrat T. Mahevas O. Fain A. Mekinian 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2019,40(10):637-644
IntroductionPatients with systemic sclerosis (SSc) have an increased risk of malignancy. In this study, we aimed to analyze the prevalence of cancer, the risk factors and the impact on overall survival.Patients and methodsWe analyzed clinical (history of cancer, toxic exposition, organ involvement), immunological and treatment data in a monocentric cohort of SSc patients followed between January 2004 and December 2017.ResultsTwo hundred and ten patients with SSc were included. During the follow-up, twenty-one patients (10 %) were diagnosed with malignancies. The underlying malignancies were breast adenocarcinoma (n = 6, 28%), lung cancer (n = 6, 28%), colorectal (colic adenocarcinoma, carcinoid tumor of the appendix), ovarian and cervix uteri, melanoma, kidney and papillary thyroid carcinoma (one of each). The median time between the first visit and the diagnosis of cancer was 4 [2–10] years. The overall survival in SSc patients with cancer was not significantly different from patients without cancer, with median survival during the first quartile (75%) at 12 years for patients with cancer and 11.6 years for those without cancer (P = 0.9). The history of renal scleroderma crisis (HR 10.99, IC95% [1.95–62.07]; P = 0.006) and the presence of anti-topoisomerase I antibodies (HR 5.5, IC95% [1.40–21.67]; P = 0.01) were associated with an increased risk of cancer, whereas the presence of gastroesophageal reflux was inversely associated with the cancer occurrence (HR 0.22, IC95% [0.056–0.867]; P = 0.03).ConclusionThe history of renal scleroderma crisis and the positivity of anti-topoisomerase I antibodies were associated with an increased risk of cancer in SSc patients in this monocentric study. 相似文献
125.
Aspirin intolerance. III. Subtypes, familial occurence, and cross-reactivity with tartarazine. 总被引:1,自引:0,他引:1
Evidence has been presented supporting the hypothesis that at least 2 different types of mechanisms may be involved in aspirin intolerance, one resulting in bronchospasm and the other producing urticaria/angioedema. Bronchospasm is the predominant symptom of aspirin intolerance in patients who have asthma. In contrast, the predominant symptom of aspirin intolerance in patients who have rhinitis is urticaria/angioedema. In the bronchospastic type of aspirin intolerance, there is a significant correlation with an increased frequency of nasal polyposis, and with a similar ageonset of asthma and aspirin intolerance. These correlations were not present in the urticari/angioedema type. Additional evidence for familial occurrence of aspirin intolerance is presented, and its relationship with subtypes of aaspirin intolerance is discussed. In a double-blind, crossover study with normal control subjects matched by age and sex 15% (6/40) of aspirin-intolerant individuals had significant adverse reactions to tartrazine challenge and not to the placebo. None of the 40 normal control subjects had any adverse reactions. 相似文献
126.
127.
目的 探讨血清microRNA-618(miR-618)表达与原发性肝癌(PHC)疗效及预后的关系.方法 选取2016年2月—2018年3月在内江市第二人民医院接受治疗的65例PHC患者为病例组,另选取同期65例健康体检者为健康组.通过实时荧光定量聚合酶链反应(qRT-PCR)检测miR-618 mRNA相对表达量,分... 相似文献