强迫症患者认知功能与病期的关系

目的：探讨强迫症的认知功能障碍与病期的关系。方法：分别用韦氏记忆测验，数字划销测验和威斯康星卡片分类测验评估25例急性强迫症和36例慢性强迫症患者的记忆、注意和执行功能。结果：急性强迫症患者的记忆测验中记图和数字划销测验中第二阶段失误率显著性较慢性强迫症差，其余两组间记忆测验、划销测验和威斯康星卡片分类测验各量表分无显著性差异。结论：强迫症的认知功能与病期无明显相关。     

Nocturnal Paroxysmal Dystonia with Short-Lasting Attacks: Three Cases with Evidence for an Epileptic Frontal Lobe Origin of Seizures

The epileptic or nonepileptic origin of nocturnal paroxysmal dystonia (NPD) has been debated. We studied three patients with frequent attacks during non-REM sleep. During prolonged video-EEG monitoring, two patients had a convulsive seizure after a typical NPD episode and on these occasions EEG showed epileptiform discharge. In the three patients, attacks occurred repeatedly with different intensity, representing "fragments" of the same seizure. These fragments of the attack could occur periodically every 20-40 s. We postulate that short NPD attacks are actually epileptic seizures originating from the frontal lobes. The rhythmicity of the episodes may be due to rhythmic oscillation of cortical function during non-REM sleep.     

升丹制剂对小鼠机械性创面微循环影响的实验研究

目的 通过不同浓度的升压制剂对创面微循环影响来控制其对创面愈合的作用机制。方法 应用彩色病理图文分析系统,分析创面微血管增生数、扩张度及微血栓数。结果 在造模后３天、７天,实验且数值均显著高于对照组。结论 升丹制课题可以和改善创面微循环,减少微血栓,增加创面营养和血供,有利创面愈合。     

国产羟苯磺酸钙的药效研究

实验证实羟苯磺酸钙能显著性降低兔血小板聚集比率、血小板粘附性、血浆与血清粘度。能增强微循环、使高分子右旋糖酐造成兔眼结膜微循环障碍的血液流态得到充分的改善。     

肾综合征出血热患者血液透析前后的血液流变性及甲襞微循环变化

目的 探讨肾综合征出血热（ＨＦＲＳ）合并争性肾功衰竭（ＡＲＦ）患者血液透析（ＨＤ）前后的血液流变性及甲臂微循环的变化规律。方法 采用瑞曲Ｇａｍｂｒｏ公司生产的ＡＫ－１０型血液透析机治疗患者４５型,血液流变学及甲臂微循环指标分别采用成都仪器厂的ＮＸＥ－１型锥板式粘度计和徐州光学仪器厂的ＭＸ－７５３Ｂ微循环显微镜检测,所得数据按田牛氏综合定量评价方法,计算综合加权积分值。结果 ＨＤ前后患者血中ＢＵＮ,     

Coronary microcirculation: autoregulation and metabolic control

The majority of studies axamining the regulation of coronary blood flow and vascular resistance have considered the coronary circulation as being composed of large conduit vessels and resistance vessels. Recently, it has become apparent that regulation of coronary microvascular resistance is not distributed uniformly, but varies across different segments or microdomains of the vasculature. Generally, small arterioles, those less than 100 m in diameter, respond differently than larger arterioles and small arteries. There are major differences in the level of autoregulatory control, myogenic control, endothelial modulation and control by metabolic factors across these various microvascular domains. There are also transmural variations which may account for some of the differences in coronary blood observed between epicardial and endocardial regions. In addition, interactions between these various regulatory mechanisms further complicate the understanding of coronary microvascular regulation. Importantly however, it may be these complex interactions and heterogeneous regulatory mechanisms which allow for adequate perfusion of the myocardium under an extreme range of metabolic conditions. This segmental distribution of regulation suggests an integrative hypothesis of regulation whereby a variety of mechanisms play a role in the overall response.Invited Contributions to the Symposium Regulation of coronary blood flow, held at the XV. World Congress of the International Society for Heart Research in Prague 1995     

Pediatric intestinal transplantation

Advancements in donor management, organ preservation and operative techniques, as well as immunosuppressive therapies, have provided children with intestinal failure and its complications a chance not only for enteral autonomy but also long-term survival through intestinal transplantation (ITx). First described in the 1960’s, experience has grown in managing these complex patients both pre- and post-transplant. The goals of this review are to provide a brief history of intestinal transplantation and intestinal rehabilitation in pediatric patients, followed by focused discussions of the indications for ITx, induction and maintenance immunosuppression therapies, common post-operative complications, and outcomes/quality of life post-transplant.     

微血管舒张功能障碍及体外反搏的改善作用

目的：通过测定微血管血流灌注来反映微血管的舒张功能,同时观察体外反搏治疗改善冠心病患者微血管舒张功能障碍的效果。方法：应用激光多普勒血流量计（ＬＤＦ） ,测量５８ 个被观察者的前臂皮肤在反应性充血前后微血管血流灌注增加比值,评价血流介导的微血管舒张功能。结果：冠心病组、高胆固醇血症组及吸烟组微血管舒张功能明显低于对照组,比值分别为１．８３±０．３７、２．６３±０．５１、３．１９ ±０．５６ 比３．５６±０．３６ ;Ｐ分别＜ ０．０１,＜０．０１,＜ ０．０５。冠心病组反搏治疗前后比,其微血管的舒张功能明显提高,比值为１．８３±０．３７ 比２．５４±０．４３; Ｐ＜０．０１。结论：ＬＤＦ可检测冠心病患者明显的微血管舒张功能障碍及高胆固醇血症者和吸烟者微血管功能的异常;体外反搏治疗可改善冠心病患者的微血管舒张功能。     

A two-illness model of bipolar disorder

The current approach to mood disorders is that bipolar disorder, comprising both mania and depression, is a discreet illness distinct from unipolar depression. This formulation has profoundly influenced the approach to understanding the biology and etiology of these disorders, as well as the manner in which the various phases of bipolar disorder are treated. Our new model suggests that bipolar disorder comprises two distinct illnesses, mania and depression, and that bipolar depression is no different from unipolar depression. Studies of clinical syndromes, course of illness, family history and genetics, biological factors, and treatment response data directly or indirectly support this new model.     

Gabapentin in the acute treatment of refractory bipolar disorder

Background: Gabapentin, a new anti-epileptic agent, has been anecdotally reported to be effective in the treatment of mania. We systematically assessed the response rate in bipolar patients being treated adjunctively with gabapentin for manic symptoms, depressive symptoms, or rapid cycling not responsive to standard treatments.
Method: Twenty-eight bipolar patients experiencing manic (n=18), depressive (n=5), or rapid-cycling (n=5) symptoms inadequately responsive to at least one mood stabilizer were treated in an open fashion with adjunctive gabapentin. Illness response was assessed using the Clinical Global Impression Scale modified for bipolar disorder (CGI-BP). A 'positive response' was operationalized as a CGI response of much or very much improved.
Results: Fourteen of the 18 (78%) treated for hypomania or mania had a positive response to a dosage range of 600–3600 mg/day. Patients with hypomania responded fastest, with a positive response achieved in 12.7±7.2 days. Patients with classic mania had a mean time to positive response of 25±12 days, and in patients with mixed mania it was 31.8±20.9 days. All of the five patients treated for depression had a positive response within 21±13.9 days. Only one of five patients with rapid cycling had a positive response. Gabapentin was well tolerated by all patients, with the most common side-effect being sedation.
Conclusions: Gabapentin appears to have acute anti-manic and anti-depressant properties as an adjunctive agent for refractory bipolar illness. Prospective double-blind studies are needed to further delineate its acute efficacy when used as monotherapy and its prophylactic efficacy as monotherapy or in conjuction with other mood stabilizers.