肠易激综合征的中医外治法概述

本文对近年来应用中医外治法治疗肠易激综合征的临床治疗文献进行了综述和分析.     

基于组分中药理论的薏苡仁-知母药对治疗糖尿病患者的配伍特点

药对是源于中医传统经方或验方,依据中药配伍原则,能长期应用并指导临床实践的两味药物相对固定的配伍形式,具有协同增效或配伍减毒的作用。薏苡仁-知母为典型的清热滋阴药对,二者相辅相成,治疗阴虚热盛型糖尿病患者效果显著。其成分知母皂苷、知母多糖、芒果苷、薏苡仁多糖等对糖尿病均有较好的干预作用。现从中医理论及现代药理学研究等层面探究薏苡仁-知母药对治疗糖尿病的配伍特点,剖析主要活性成分的降糖作用和作用机制,为治疗糖尿病的新药研究提供理论基础。     

L-Serine Treatment is Associated with Improvements in Behavior,EEG, and Seizure Frequency in Individuals with GRIN-Related Disorders Due to Null Variants

Pathogenic missense variants in GRIN2A and GRIN2B may result in gain or loss of function (GoF/LoF) of the N-methyl-D-aspartate receptor (NMDAR). This observation gave rise to the hypothesis of successfully treating GRIN-related disorders due to LoF variants with co-agonists of the NMDAR. In this respect, we describe a retrospectively collected series of ten individuals with GRIN2A- or GRIN2B-related disorders who were treated with L-serine, each within an independent n-of-1 trial. Our cohort comprises one individual with a LoF missense variant with clinical improvements confirming the above hypothesis and replicating a previous n-of-1 trial. A second individual with a GoF missense variant was erroneously treated with L-serine and experienced immediate temporary behavioral deterioration further supporting the supposed functional pathomechanism. Eight additional individuals with null variants (that had been interpreted as loss-of-function variants despite not being missense) again showed clinical improvements. Among all nine individuals with LoF missense or null variants, L-serine treatment was associated with improvements in behavior in eight (89%), in development in four (44%), and/or in EEG or seizure frequency in four (44%). None of these nine individuals experienced side effects or adverse findings in the context of L-serine treatment. In summary, we describe the first evidence that L-serine treatment may not only be associated with clinical improvements in GRIN-related disorders due to LoF missense but particularly also null variants.Supplementary InformationThe online version contains supplementary material available at 10.1007/s13311-021-01173-9.     

多药联合治疗小儿过敏性紫癜疗效分析

目的:为探索治疗小儿过敏性紫癜(HSP)最佳方案.方法:在对症治疗基础上,采用丹参加普鲁卡因静滴联合西米替叮口服治疗小儿过敏性紫癜60例,并将其疗效与以往治疗方法作对比分析.结果:丹参加普鲁卡因治疗的疗效明显优于原治疗方法.有效率91.66%.平均住院时间为(11.08±2.20)天,与原两治疗方法比较有减少,经统计学处理有显著性差异.结论:本治疗方法对小儿过敏性紫癜有明显疗效,且治疗方便,价格低廉,未发现毒副作用,适于基层医疗单位推广应用.     

中药方剂缓解育龄女性子宫切除后更年期症状的研究

目的:探讨中药方剂缓解育龄女性子宫切除后更年期症状的效果及作用机理。方法:选取因子宫良性病变行子宫全切术的病例98例随机分为2组,分别为观察组、对照组。观察组术后在西医抗炎、止血、补液治疗的基础上配合中药方剂治疗。对照组术后只行西医抗炎、止血、补液治疗。结果:2组术后2个月,对其进行更年期临床症状测定,2组比较差异有统计学意义(P<0.05)。结论:中药方剂缓解育龄女性子宫切除后更年期症状的效果有可行性且效果颇佳。     

穴位埋线疗法治疗单纯陛肥胖症有效性的系统评价

目的：系统评价穴位埋线疗法对单纯性肥胖症的治疗效果。方法：计算机检索中国知网（CNKI）、万方数据资源系统、中国生物医学文献数据库中关于穴位埋线疗法对单纯性肥胖症效果的随机对照试验,用ladad质量计分法对纳入研究的质量进行评价,结局指标采用ReviewManage5．1软件分析。结果：最终纳入16．g随机对照试验文献。Meta分析结果显示,穴位埋线治疗单纯性肥胖症总有效率与对照组相比,差异有统计学意义[OR=2．51,95％可信区间（1．74,3．63）,Z=4．91,P〈0．000011;文献质量评价显示,仅1篇文献得3分,其余15篇文献得分≤2分,文献质量普遍较低,发表存在偏倚,且对盲法、退出失访及随访的追踪报道过少;统计治疗选穴共有27个穴位,以天枢、中脘、丰隆、水分、阿是穴、大横等穴为主。结论：穴位埋线治疗单纯性肥胖症疗效肯定,但其临床有效性尚缺乏充分证据,因此．还需进一步临床研究才能为今后临床决策提供可靠依据。     

中药方剂防治骨质疏松症的研究概况

中药方剂具有疗效好、副作用小、作用全面、适合长期服用等优势,已广泛应用于骨质疏松的防治。经典方来源于古代医书记载,疗效确切,临床上通过辨证施治,可随证对处方进行加减化裁;经验方来源于医师多年临床经验,处方组成相对固定,各自具有自身的特点,适用于特定证候类型的骨质疏松症;中成药的处方、剂型固定,服用方便,可单独使用,或与化学药物配伍使用。中药方剂防治骨质疏松症具有独特的优势,但尚有许多不足,应从整体、器官、组织、细胞和分子水平上系统研究其作用机制和特点。     

中西医结合高等本科教育的思考

中西医结合高等本科教育自1991年广州中医药大学在七年制中医学专业中开设中西医结合临床医学方向起步,至今已有15年的历程.在这个发展历程中,中西医结合高等本科教育取得了有目共睹的成就.但是目前中西医结合本科教育的发展还远远滞后于社会需要,为此,我们必须认清现状,把握机遇,勇于挑战,促进中西医结合教育事业及整个中西医结合事业长足发展.