参与植物三萜生物合成的细胞色素P450酶研究进展

三萜是许多药用植物的活性成分,目前已对其生物合成途径进行了大量研究并取得了重大进展。细胞色素P450(CYP450)主要参与三萜的后修饰过程,对三萜的多样性起着关键作用。目前,已从多种植物中克隆得到与三萜生物合成相关的CYP450基因。对参与三萜生物合成的CYP450的功能研究进行综述,为三萜生物合成途径的解析及CYP450的功能研究提供借鉴。     

柴胡黄芩药对的基础研究探析

柴胡和黄芩是临床上常见的中药配伍,是《伤寒论》中最具代表意义的药对配伍之一,作为经典药对广泛运用于呼吸系统、消化系统、心血管系统和神经系统疾病的复方治疗中。研究发现,柴胡黄芩药对配伍可以提高柴胡皂苷和黄芩苷的溶出量,这可能该是药对配伍药效增强的物质基础。现代药理研究表明,柴黄药对具有缓解肝损伤、抗肝纤维化、抗病毒、解热抗炎、治疗肝癌、利胆和抗癫痫等作用。本文从配伍后主要药效成分溶出研究和药理作用等方面对柴胡黄芩药对的文献进行综述,以期为其深入开发提供参考。     

运动疗法联合中药熏洗治疗踝关节创伤性关节炎的疗效分析

目的:探析对踝关节创伤性关节炎患者采取运动疗法联合中药熏洗治疗的临床效果。方法:收集我院74例踝关节创伤性关节炎患者,按照治疗方法的不同将其分为对照组(37例)、观察组(37例),给予对照组中药熏洗治疗,予以观察组运动疗法加中药熏洗,对比两组的疼痛视觉模拟评分、踝关节功能评分及临床疗效。结果:治疗后,观察组的疼痛视觉模拟评分(2.61±0.58)分低于对照组(3.56±0.74)分,踝关节功能评分(87.51±5.43)分明显高于对照组(76.04±4.21)分,差异有统计学意义(P<0.05);且其治疗总有效率(97.30%)与对照组(75.68%)相比更高,P<0.05,差异有统计学意义。结论:对踝关节创伤性关节炎患者采用运动疗法联合中药熏洗治疗,可有效缓解患者的疼痛程度、改善踝关节功能,提高治疗疗效,临床价值高。     

生物学技术在药用植物鉴定中的研究进展

药用植物种质资源是中医药现代化发展的根基,深入研究药用植物种质资源是培育优良品种、保证中药产量和规范质量的前提条件.传统的鉴别方法从表观出发,受自然环境和人为因素影响较大,鉴定的效率和准确性普遍偏低.分子生物学技术以其易操作、高灵敏度、结果准确等优点,已被广泛用于药用植物种质资源的相关研究中,主要涉及野生与栽培品区分、...     

中草药浸提温度对有效成分浸出浓度的影响

目的：建立中草药浸提过程的温度与有效成分浸出浓度之间的关系的数学模型，方法：在前文提出的中草药浸提过程动力学模型的基础上，进一步研究扩散系数和浓度梯度随温度的变化。结果：对不同温度下从丹参Ｓalvia miltiorrhizaBge.中浸提有效成分丹参酮（tanshinone)的实验表明，该模型能满意地反映实验事实，结论：本工作建立的模型能描述湿度与有效成分浸出浓度之间的关系。     

立足资源优势保护环境和濒危药源发展中国银杏药业——恒源药业(集团)公司发展模式探讨

本文分析了我国银杏资源及相关产品、产业现状,并对恒源药业(集团)的发展模式进行了研究、分析。     

Common mullein (Verbascum thapsus L.): recent advances in research

Common mullein (Verbascum thapsus L.) is a medicinal plant readily found in roadsides, meadows and pasture lands and has been used to treat pulmonary problems, inflammatory diseases, asthma, spasmodic coughs, diarrhoea and migraine headaches. Although it has been used medicinally since ancient times, the popularity of common mullein has been increasing commercially for the past few years. Today, the dried leaves and flowers, swallow capsules, alcohol extracts and the flower oil of this plant can easily be found in health stores in the United States. The use of common mullein extracts in folk medicine begun recently to be supported by an increasing number of research studies. This paper thoroughly reviews all the scientific research related to Verbascum thapsus L. including plant tissue cultures and the biological properties of this plant.     

Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase[sol ]cyclooxygenase

Arachidonate 5-lipoxygenase is the key enzyme in leukotriene biosynthesis and catalyses the initial steps in the conversion of arachidonic acid to biologically active leukotrienes. Leukotrienes are considered as potent mediators of inflammatory and allergic reactions and regarding their pro-inflammatory properties the inhibition of 5-lipoxygenase pathway is considered to be interesting in the treatment of a variety of inflammatory diseases. Besides 5-lipoxygenase inhibitors, drugs able to block the 5-lipoxygenase as well as the cyclooxygenase metabolic pathway are also of therapeutic value. A potential source for new 5-lipoxygenase inhibitors is undoubtedly provided by the abundance of medicinal plants used in traditional medicine. The present review article reports the results from a comprehensive literature search of plants that have been tested for 5-lipoxygenase inhibitory activity over the past 15 years. The obtained information is summarized in a tabular format and promising plant species and chemical classes of compounds are presented. Relevant in vitro tests are also described in this article.     

中药注射液治疗冠心病心绞痛概述

临床上常用参麦注射液、刺五加注射液、灯盏花素注射液、灯盏细辛注射液、红花注射液、黄芪注射液、疏血通注射液、杏丁注射液、血塞通注射液等治疗冠心病心绞痛,本文概述了其应用及疗效.     

Fertilization-induced changes in growth parameters and antioxidant activity of medicinal plants used in traditional Arab medicine

In response to increased popularity and greater demand for medicinal plants, a number of conservation groups are recommending that wild medicinal plants be brought into cultivation systems. We collected four medicinal herbs Cichorium pumilum, Eryngium creticum, Pistacia palaestina and Teucrium polium used in traditional Arab medicine for greenhouse cultivation to assess the effects of different fertilization regimes on their growth and antioxidant activity. Wild seedlings were collected and fertilized with either 100% Hoagland solution, 50% Hoagland solution, 20% Hoagland solution or irrigated with tap water. Plant height was measured and the number of green leaves and branches counted weekly. Thereafter, the aboveground parts of plants were harvested for preparing a water-soluble powder extracts of which antioxidant activity was measured by their ability to suppress the oxidation of beta-carotene. Of the fertilization regimes, we found either 20 or 50% Hoagland solution produced the most consistent response of the plant growth parameters. All powders prepared from the four wild growing plants inhibited oxidation of beta-carotene. Increasing the amount of fertilizer caused a significant concentration-dependent increase in antioxidant activity of the cultivated T. polium compared with the wild type. In contrast, increasing the amount of fertilizer caused a significant concentration-dependent reduction in the antioxidant activity of powders prepared from the cultivated E. creticum when compared with wild plants. Our results showed that cultivation success should not rely solely on parameters of growth but should incorporate assessment related to indices of therapeutic potential.