全文获取类型
收费全文 | 46190篇 |
免费 | 3682篇 |
国内免费 | 868篇 |
专业分类
耳鼻咽喉 | 152篇 |
儿科学 | 414篇 |
妇产科学 | 394篇 |
基础医学 | 2227篇 |
口腔科学 | 494篇 |
临床医学 | 5532篇 |
内科学 | 2966篇 |
皮肤病学 | 410篇 |
神经病学 | 605篇 |
特种医学 | 1063篇 |
外科学 | 2555篇 |
综合类 | 12717篇 |
现状与发展 | 3篇 |
一般理论 | 38篇 |
预防医学 | 15786篇 |
眼科学 | 304篇 |
药学 | 2267篇 |
291篇 | |
中国医学 | 2007篇 |
肿瘤学 | 515篇 |
出版年
2024年 | 95篇 |
2023年 | 656篇 |
2022年 | 1169篇 |
2021年 | 1865篇 |
2020年 | 2181篇 |
2019年 | 1407篇 |
2018年 | 1334篇 |
2017年 | 1360篇 |
2016年 | 1348篇 |
2015年 | 1305篇 |
2014年 | 3316篇 |
2013年 | 3429篇 |
2012年 | 3215篇 |
2011年 | 3544篇 |
2010年 | 2947篇 |
2009年 | 2560篇 |
2008年 | 2880篇 |
2007年 | 2605篇 |
2006年 | 2285篇 |
2005年 | 1893篇 |
2004年 | 1521篇 |
2003年 | 1198篇 |
2002年 | 906篇 |
2001年 | 791篇 |
2000年 | 663篇 |
1999年 | 509篇 |
1998年 | 438篇 |
1997年 | 405篇 |
1996年 | 350篇 |
1995年 | 327篇 |
1994年 | 239篇 |
1993年 | 119篇 |
1992年 | 134篇 |
1991年 | 187篇 |
1990年 | 166篇 |
1989年 | 154篇 |
1988年 | 147篇 |
1987年 | 117篇 |
1986年 | 140篇 |
1985年 | 114篇 |
1984年 | 105篇 |
1983年 | 87篇 |
1982年 | 92篇 |
1981年 | 59篇 |
1980年 | 75篇 |
1979年 | 37篇 |
1978年 | 58篇 |
1977年 | 58篇 |
1976年 | 58篇 |
1975年 | 39篇 |
排序方式: 共有10000条查询结果,搜索用时 984 毫秒
991.
《Journal of pharmaceutical sciences》2019,108(7):2207-2237
This review describes the landscape of novel modalities such as cell and gene therapies, viruses, other novel biologics, oligomers, and emerging technologies, including modern analytics. We summarize the regulatory history and recent landmark developments in some major markets and examine specific chemistry, manufacturing, and controls (CMC) challenges, including suggestions for exploration of potential science-based approaches in support of regulatory strategy development from an industry perspective. In addition, we evaluate the economic factors contributing to patient access to innovation and discuss the impact of regulation. There is a desperate need for a consistent form of regulation where global approaches to regulatory strategies can be harmonized, and specific CMC challenges can be dealt with using the appropriate science and risk-based tools. Although these tools are well described in current guidance documents, the specifics of applicability to complex novel modalities can still result in differing regulatory advice and outcomes. The future goals for efficiently regulating innovative modalities and technologies could be aided by more regulatory harmonization, regulatory education, and industry cooperation through consortia, enabling industry to supply key information to regulators in a transparent yet well-defined manner, and utilizing mutually understood risk-benefit analyses to produce drugs with appropriate safety, efficacy, and quality characteristics. 相似文献
992.
993.
Mahesh V. Madhavan Bernard J. Gersh Karen P. Alexander Christopher B. Granger Gregg W. Stone 《Journal of the American College of Cardiology》2018,71(18):2015-2040
Coronary artery disease (CAD) is a major cause of morbidity and mortality in patients ≥80 years of age. Nonetheless, older patients have typically been under-represented in cardiovascular clinical trials. Understanding the pathophysiology, epidemiology, and optimal means of diagnosis and treatment of CAD in older adults is crucial to improving outcomes in this high-risk population. A patient-centered approach, taking into account health status, functional ability and frailty, cognitive skills, and patient preferences is essential when caring for older adults with CAD. The present systematic review focuses on the current knowledge base, gaps in understanding, and directions for future investigation pertaining to CAD in patients ≥80 years of age. 相似文献
994.
995.
《Journal of acupuncture and meridian studies》2014,7(3):105-114
This paper presents some previously proposed neurobiological mechanisms on how acupuncture may work in some clinical applications from a clinician's perspective. For the treatment of musculoskeletal conditions, the proposed mechanisms included microinjury, increased local blood flow, facilitated healing, and analgesia. Acupuncture may trigger a somatic autonomic reflex, thereby affecting the gastric and cardiovascular functions. Acupuncture may also change the levels of neurotransmitters such as serotonin and dopamine, thereby affecting the emotional state and craving. This mechanism may form the basis for the treatment of smoking cessation. By affecting other pain-modulating neurotransmitters such as met-enkephalin and substance P along the nociceptive pathway, acupuncture may relieve headache. Acupuncture may affect the hypothalamus pituitary axis and reduce the release of the luteinizing hormone in the treatment of polycystic ovary syndrome. In addition, two other approaches to the acupuncture mechanism, the fascia connective tissue network and the primo vascular system, are briefly reviewed. Finally, the idea of true versus sham acupuncture points, which are commonly used in clinical trials, is examined because the difference between true and sham points does not exist in the neurobiological model. 相似文献
996.
997.
目的 为了遵循医学人才培养规律,规范医学人才培养体制,提高医学人才培养质量,探索符合我国实际需求的医学人才培养模式。方法 采用问卷调查法对全国140所高等医学院校进行调查,并对相关调查结果进行分析。结果 ①86.96%的高校对统一规范为“5+3”一体化为主体,同时参加住院医师规范化培训,毕业合格者授予医学博士(MD)学位表示赞成。②76.80%的高校对将“5+3”一体化作为培养全科医生主要渠道的医学博士培养体系表示赞成。③90.40%的高校对通过“5+3+X”一贯制培养授予MD+PhD项目,培养复合型高水平临床医学人才表示赞成。④84.80%的高校对医学学位授予与专科医师规范化培训相脱离,后者应纳入职业培训范畴表示赞成。结论 全面推进落实“5+3”为主体的高素质临床医学相关人才培养模式,将培养目标定位为以满足社会需求的高水平全科医生为主体,加快高层次复合型医学人才的培养体系建设。 相似文献
998.
José G. Cabañas Jefferson G. Williams John M. Gallagher Jane H. Brice 《Prehospital emergency care》2021,25(1):8-15
Abstract The COVID-19 pandemic is a worldwide historical event that will continue to affect nearly every aspect of ordinary life, including affecting our economic, political, and healthcare eco-systems. An effective pandemic response demands a coordinated and integrated response across community healthcare stakeholders, including Public Health and Emergency Management Officials. EMS systems are in a unique position and perform an essential role on the frontlines of COVID-19, including facilitating coordination of response efforts to COVID-19 within their communities while supporting public health mitigation efforts to slow the spread of the SARS-CoV-2. EMS physicians serve their communities at a unique intersection as clinical leaders, population health experts, and advocates. This paper examines and recommends crucial roles for EMS physician leaders as communities work together in pandemic response. 相似文献
999.
《Journal d'obstetrique et gynecologie du Canada》2022,44(11):1167-1173
ObjectiveThe COVID-19 pandemic necessitated a shift from traditional in-person instruction for learning new technical skills to virtual delivery of medical education training. The objectives of this study were to develop and evaluate a virtual simulation-based training program for Canadian health care professionals (HCPs) on the insertion, localization, and removal of the etonogestrel subdermal contraceptive implant.MethodsA scientific committee of Canadian family planning experts developed a 2-part virtual training program during the COVID-19 pandemic. Core educational content (part 1) was provided in an asynchronous, self-directed, online format. Part 2 consisted of synchronous, simulation-based training using web conferencing. The HCPs were provided with model arms and placebo applicators; the trainers demonstrated implant insertion and removal techniques, and trainees received individual feedback. All trainees were asked to complete an online evaluation upon completion of the program.ResultsBetween September 22, 2020, and December 31, 2021, 83 trainers conducted 565 virtual training sessions. A total of 3162 HCPs completed part 1 of the training program, of whom 2740 had completed part 2 by December 31, 2021. Participants reported high levels of satisfaction with virtual simulation-based training; 96.5% of respondents (1570/1627) agreed that the virtual format was effective. Additional training prior to inserting the implant in clinical practice was requested by 4.5% of respondents (75/1671).ConclusionVirtual simulation-based learning provides effective education and technique training for etonogestrel implant insertion and removal. Online training for implant use can be scaled, as needed, to reach professionals in remote or underserved locations. This virtual training approach may be appropriate for other technical or minor surgical procedures. 相似文献
1000.
《Seminars in perinatology》2022,46(3):151526
Perinatal palliative care has grown out of both an historical necessity in attending to babies in the NICU that face difficult odds of survival, the increasing technology that may avail life-extending, yet technology-dependent, care, and the growth of fetal diagnostic and treatment centers. This review looks ta the history and ethical rationale for making available services from Pediatric and Perinatal Palliative Care to families in the prenatal and postnatal periods caring for a loved one with life-limiting circumstances. 相似文献