全文获取类型
收费全文 | 52861篇 |
免费 | 6209篇 |
国内免费 | 1807篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 1135篇 |
妇产科学 | 200篇 |
基础医学 | 4603篇 |
口腔科学 | 59篇 |
临床医学 | 4866篇 |
内科学 | 7783篇 |
皮肤病学 | 114篇 |
神经病学 | 290篇 |
特种医学 | 2213篇 |
外国民族医学 | 97篇 |
外科学 | 3984篇 |
综合类 | 10245篇 |
现状与发展 | 10篇 |
预防医学 | 2120篇 |
眼科学 | 41篇 |
药学 | 5711篇 |
37篇 | |
中国医学 | 2593篇 |
肿瘤学 | 14739篇 |
出版年
2024年 | 213篇 |
2023年 | 1015篇 |
2022年 | 2022篇 |
2021年 | 2783篇 |
2020年 | 2418篇 |
2019年 | 1969篇 |
2018年 | 1893篇 |
2017年 | 2285篇 |
2016年 | 2518篇 |
2015年 | 2647篇 |
2014年 | 3673篇 |
2013年 | 3947篇 |
2012年 | 3300篇 |
2011年 | 3516篇 |
2010年 | 2765篇 |
2009年 | 2564篇 |
2008年 | 2552篇 |
2007年 | 2764篇 |
2006年 | 2422篇 |
2005年 | 2140篇 |
2004年 | 1722篇 |
2003年 | 1421篇 |
2002年 | 1168篇 |
2001年 | 1035篇 |
2000年 | 828篇 |
1999年 | 651篇 |
1998年 | 566篇 |
1997年 | 565篇 |
1996年 | 487篇 |
1995年 | 373篇 |
1994年 | 365篇 |
1993年 | 281篇 |
1992年 | 303篇 |
1991年 | 255篇 |
1990年 | 217篇 |
1989年 | 177篇 |
1988年 | 175篇 |
1987年 | 152篇 |
1986年 | 126篇 |
1985年 | 108篇 |
1984年 | 88篇 |
1983年 | 67篇 |
1982年 | 69篇 |
1981年 | 56篇 |
1980年 | 62篇 |
1979年 | 45篇 |
1978年 | 28篇 |
1977年 | 25篇 |
1976年 | 13篇 |
1975年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
101.
8-硝基白杨素的合成及其抗肿瘤作用 总被引:5,自引:0,他引:5
目的 探讨 8-硝基白杨素的抗肿瘤活性。方法 荷Lewis肺癌雄性小鼠 5 0只 ,随机分为5组 (NS对照组 ,环磷酰胺组 ,低、中、高剂量 8-硝基白杨素组 ) ,每组 1 0只 ,均采用腹腔注射给药。末次给药 2 4h后 ,颈椎脱位处死小鼠 ,观察各组瘤重减轻情况及转移结节数。结果 低、中、高剂量 8-硝基白杨素均能明显抑制肿瘤的生长和肿瘤转移结节的数 (阳性药对照组和各处理组与对照组相比 ,P均<0 .0 1 ) ,高剂量 ( 5 0mg kg) 8-硝基白杨素与 1 0 0mg kg的环磷酰胺的抗肿瘤作用相当 (P >0 .0 5 )。结论 8-硝基白杨素作为一种新黄酮衍生物 ,具有良好的抗肿瘤作用。 相似文献
102.
Symptomatic renal metastasis 5 years after the management of a squamous cell carcinoma of the lung 总被引:1,自引:0,他引:1
BULENT AKDUMAN REMZI ALTUN CETIN YESILLI SIBEL YENIDUNYA HUSEYIN OZDEMIR NECMETTIN AYDIN MUNGAN 《International journal of urology》2004,11(6):421-423
A case of solitary renal metastasis five years after the management of a primary squamous cell carcinoma of the lung is presented. 相似文献
103.
用ELISA检测肺癌患者血清中Endostatin的变化 总被引:2,自引:0,他引:2
目的建立快速敏感的ELISA方法检测肺癌患者血清内皮抑素(Endostatin)。方法对41例肺癌患者及22例良性肺病患者进行血清Endostatin测定并与20例正常人进行比较。结果肺癌患者体内Endostatin水平高于良性肺病患者和正常人。结论快捷的ELISA检测法可以成为人们在临床及基础研究Endostatin的新方法。 相似文献
104.
应用数据挖掘技术获取周围型肺癌临床和CT诊断规则的初步研究 总被引:1,自引:0,他引:1
目的探讨数据挖掘技术对周围型肺癌影像诊断规则提取的价值。方法收集58例经过临床病理证实的周围型肺癌病例,对其临床及CT表现属性进行标准化认定,输入数据库,分别采用自主开发的基于关联规则知识发现程序与通用数据分析工具ROSETTA中的粗糙集约简算法和遗传分类算法对58例周围型肺癌临床及影像学数据进行挖掘对比研究。结果由Johnson’s Algorithm粗糙集约简算法产生诊断规则51条,由ROSETTA遗传分类算法所产生的诊断规则有5千多条,基于关联规则的挖掘算法所产生的诊断规则有123条。这3种不同的数据挖掘方法产生的最重要的诊断规则基本上都将性别、年龄、位置、毛刺、形状、毛玻璃样密度等属性作为诊断周围型肺癌的主要依据。结论数据挖掘技术在医学影像诊断和鉴别诊断中具有潜在的应用价值。 相似文献
105.
106.
Kidney Disease After Heart and Lung Transplantation 总被引:2,自引:0,他引:2
Kidney disease is a commonly recognized complication of heart and lung transplantation and is associated with increased morbidity and mortality. While the spectrum of kidney disease in this population is wide-ranging, studies indicate that between 3% and 10% of these patients will ultimately develop end-stage renal disease (ESRD). This review examines the risk factors for both acute and chronic kidney injury, with a particular emphasis on the role of calcineurin inhibitor-mediated nephrotoxicity in both these settings. Against the background of current National Kidney Foundation Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines, we have further considered and recommended appropriate strategies for long-term management of kidney disease-related manifestations in heart and lung transplant recipients. Specific aspects addressed include retarding progressive renal injury and minimizing nephrotoxicity, as well as treatment of hypertension, hyperlipidemia and anemia. Finally, for patients in this population with advanced kidney disease, renal replacement therapy options are discussed. Based on the impact of chronic kidney disease on outcomes in both heart and lung recipients, we advocate early referral to a nephrologist for patients displaying evidence of significant renal dysfunction. 相似文献
107.
Ken Yamaguchi Katsumi Aoyagi Ken-ichi Urakami Toyoharu Fukutani Noboru Maki Shigehiro Yamamoto Kotomi Otsubo Yoshio Miyake Tetsuro Kodama 《Cancer science》1995,86(7):698-705
Our previous study demonstrated that pro-gastrin-releasing peptide(31–98), or ProGRP, is a specific tumor marker in patients with small cell lung carcinoma (SCLC). Using a newly developed, highly sensitive enzyme-linked immunosorbent assay (ELISA) for ProGRP, we analyzed 1,446 samples including those obtained from 478 lung cancer patients to evaluate the clinical usefulness of this ELISA. Several properties indicated that ProGRP is a useful tumor marker for SCLC. First, ProGRP was specifically elevated in SCLC patients. In non-SCLC patients and patients with non-tumorous lung diseases, its serum level was very rarely elevated. Secondly, ProGRP was a reliable marker, in terms of the marked elevation of serum ProGRP levels in SCLC patients. Thirdly, serum ProGRP levels were elevated in SCLC patients even at a relatively early stage of this disease. Fourthly, changes in the serum ProGRP level showed an excellent correlation with the therapeutic responses in SCLC patients. Neuron-specific enolase (NSE) is accepted as a tumor marker of SCLC patients. With the aim of comparing ProGRP and NSE as tumor markers for SCLC patients, we measured serum NSE levels in all samples collected in the present study. We found that ProGRP was superior to NSE in terms of sensitivity, specificity and reliability. Therefore, we consider that ProGRP can play a major role as a clinical tumor marker for SCLC patients. 相似文献
108.
Previous work from this laboratory has already indicated that capsaicin, stabilizes the rat lung membrane lipid system on long-term treatment. This stabilization of the membrane is further supported by our present findings that capsaicin pretreatment causes significant inhibition of various chemically induced lipid peroxidative changes at both cellular and subcellular levels. Both in vivo and in vitro studies, using whole lung and liver tissue slices and mitochondrial and microsomal fractions, have shown that capsaicin pretreatment inhibits peroxidative changes at both cellular and subcellular levels. Both in vivo and in vitro studies, using whole lung and liver tissue slices and mitochondrial and microsomal fractions, have shown that capsaicin pretreatment inhibits peroxidative changes induced by different chemical irritants such as chloroform, dichloromethane, carbon tetrachloride as well as ferrous sulphate. 相似文献
109.
110.
Mercury ingested from dietary sources has potent neurotoxic and teratogenic effects. Initial studies have shown that mercury may also affect fetal lung development. Since these pulmonary effects may play a role in subsequent neonatal morbidity and mortality due to compromising of the development of the lung, mercury effects in fetal and neonatal lung were investigated. Methylmercuric chloride (MMC), 1,000 ppm (15 mg/kg of body weight), was administered via an intragastric tube to timed-pregnant Swiss/Webster mice on day 9 of gestation. Lungs from fetuses on gestational day 18 and from neonates on days 1, 5, or 10 after birth were studied. Significant changes in MMC-exposed lungs compared to controls occurred at postnatal day 1. At this time, lung weight per gram body weight increased, phospholipid content per gram of lung or per microgram of DNA decreased, while DNA per gram of lung increased. Methylmercury appears to have delayed lung maturation. Cuboidal epithelial cells in alveolar tubules contained conspicuous glycogen deposits, and differentiation of alveolar type II cells was adversely affected. These results suggest that prenatal exposure to methylmercury may be detrimental to lung development, specifically to the initiation of surfactant synthesis, by delaying the normal pattern of maturation of the alveolar type II cells within the lungs. Pediatr Pulmonol. 1994; 17:11–21 . © 1994 Wiley-Liss. Inc. 相似文献