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81.
O. F. M. SELLEVOLD T. M. BERG K. A. REIN O. W. LEVANG O–J. IVERSEN K. BERGH 《Acta anaesthesiologica Scandinavica》1994,38(4):372-379
A prospective randomized study was performed to investigate the effect of surface coating with covalently endpoint–attached heparin (Carmeda Bio Active Surface) and reduced general heparinization on haematological indices and complement C5 activation. Care was taken to optimize the rheological design of the system using centrifugal pump and a closed system without venting or machine suction. Twenty patients scheduled for aortocoronary bypass grafting (EF > 0.5) participated in the study. Ten patients were randomized to be treated with heparin–coated equipment (CBAS) and reduced i.v. heparin (1.5 mg kg-1) while 10 patients treated with identical but noncoated equipment and full heparinization (3 mg–kg-1) served in a Control group. A vacuum suction was used to collect the blood from the operating field and it was autotransfused at weaning from extracorporeal circulation (ECC). Blood samples were obtained from the venous (precircuit) and arterial (postcircuit) side. We used a new and very specific method for detection of C5a based on monoclonal antibodies. The concentration of C5a was low in both groups during the operation but a significant increase was seen on days 1 and 2. In the Control group there was an increase from 10.2 ngml-1±1.2 to 27.5 ng ml-1 ± 4.8 on day 2 and in the CBAS group from 10.7 ng ml-1 ± 1.2 to 35.6 ng ml-1 ± 11.6 on day 2 (NS between groups). The granulocytes and total leukocyte count increased at the end of ECC and was maintained at the elevated level throughout the study period. The amount of free haemoglobin was high in the autotransfused blood in both groups. The present results confirm the feasibility of reducing general heparin when using heparin–coated systems but the study does not support the superiority of such coating with regard to biocompatibility in short procedures with a Theologically optimized circuit. The potential benefit from reduced heparin and protamine has not been fully evaluated. 相似文献
82.
应用肝素雾化治疗小儿哮喘性疾病(包括以喘为主的支气管肺炎)16例,其咳喘症状消失和肺部体征消失时间校对照组快,总显效率高。文中还就7例肝素雾化治疗前后血气结果对照,进一步阐述肝素雾化有利于改善通气功能,促进二氧化碳排出和炎症吸收,从而解除支气管痉挛的机理。具有疗效显著,安全可靠,无任何副作用的特点,值得临床推广应用。 相似文献
83.
0~16岁城乡儿童骨骼矿物质含量及影响因素的研究 总被引:6,自引:1,他引:5
使用单光子骨矿物测定仪,自1994年初到1995年底,分别在河南省扶沟县和新乡市测定了332名健康的0~16岁城乡儿童右前臂1/3处桡骨和尺骨的骨矿物质含量(BMC),采用逐步多元回归分析了多个独立变量对桡骨BMC和测量部位骨宽度的影响。结果显示:桡骨和尺骨的BMC、骨宽度(BW)、BMC/BW和前臂长度均随年龄而增加,0~6岁城市儿童的BMC高于农村儿童;桡骨BMC与所测量部位的BW呈正相关,年龄、体重和身高对桡骨BMC都显示出显著和独立的正影响;儿童的桡骨BMC与年龄呈显著正相关;而桡骨BMC与体重的比值与年龄呈显著负相关;测定部位桡骨BW和前臂长度随年龄的增加呈曲线增加。在以身高和体重调整后,性别、年龄和体重对桡骨BW的影响变得不显著,只有身高的影响显著。本研究证明儿童在0~16岁范围,身高(而不是肥胖)是骨骼BMC的主要决定因素。在比较儿童骨密度结果时,要参考多个变量,如BMC、骨密度,BMC/体重、BMC/年龄等综合评价指标更有说明力。 相似文献
84.
Because attitudes concerning a topic can diminish the effectiveness of educational materials, previously identified attitudes concerning calcium intake were explored through focus group interviews during the developmental stages of calcium education materials. Although four focus groups of six to seven participants were planned, each of the four groups consisted of two to six women. All focus groups followed the same format, lasting for 60–90 min; questions progressed from the general to more specific. The focus groups revealed several attitudinal barriers toward dietary behavioural change, including lack of prior interest in the topic and lack of time. Attitudes about dairy calcium included the belief that dairy foods were high in fat and should be avoided, and the belief that dairy foods would cause stomach upsets. Also, neither younger nor older women felt that osteoporosis was a problem their age group needed to address. Readability scales were not necessarily predictive of preference. This study shows that focus group interviews make a valuable contribution to planning and evaluating nutrition education materials. 相似文献
85.
Li Ming Yang Jing Shen Guan-xin Zhang Qian Liu Shen-pei Liu Zhong-bei Ye Wei-xin 《华中科技大学学报(医学英德文版)》1994,14(4):209-212
Summary T cell activation and proliferation via CD3-TCR complex were investigated by lymphocyte DNA synthesis in vitro. Several interfering factors were also discussed. The
result indicated that lymphocyte activation and proliferation are calciumdependent. A rise of cytoplasmic free Ca2+ quickly following activation with CD3 McAb is mainly due to intracellular mobilization of Ca2+, while lymphocyte proliferation needs both intracellular mobilization of Ca2+ as well as influx of extracellular Ca2+. It was confirmed that CTX sensitive G protein plays a role in regulating T cell proliferation by pretreatment with CTX suppressing
lymphocyte3H-TdR incorporation obviously. PLC and PKC inhibitor neomycin and P. S. S could also decrease T cell proliferation. 相似文献
86.
87.
本实验建立了一种浮动基点式fura-2测定离体灌流心脏细胞内游离钙浓度的新模型,本模型中游动基点式测定地克服目前fura-2技术中受细胞内某些物质产生的自身荧光变化干扰的缺点,实现了自动消除细胞自身荧光变化对实验结果的影响,并在此基础上将广泛用于测定游离状态的细胞内游离钙的tura-2技术推广到离体灌流心脏,实现了在更接近心肌生理状态的条件下测定其胞浆游离钙。 相似文献
88.
Glutamate is the primary excitatory amino acid in the mammalian central nervous system. Normal excitation of glutamate receptors initiates the stimulation of phospholipases and lipases with the generation of second messengers that are necessary for normal cell function. The overstimulation of glutamate receptors can initiate a cascade of biochemical events including stimulation of membrane phospholipid turnover, excessive calcium entry, abnormal phosphorylation, and proteolysis. These events may be responsible for neuronal injury and degeneration found in Alzheimer disease, ischemia, spinal cord trauma, epilepsy, and Huntington disease. 相似文献
89.
90.
目的研究不同月龄的雄性大鼠成骨细胞内钙浓度及钙通道电流是否存在差异.方法采用二次酶消化法分离不同月龄(分别为1、2、3、5、7、9、11、13、15)雄性大鼠的原代成骨细胞,通过激光扫描共聚焦技术测定细胞内游离钙浓度([Ca2+]i)(以平均荧光强度表示),同时应用全细胞膜片钳技术记录成骨细胞膜钙电流(ICa)的变化.结果共聚焦结果显示随月龄增加,成骨细胞内[Ca2+]i逐渐降低,但相邻2月龄组之间细胞内[Ca2+]i无显著性差异(P>0.05);1、2、3月龄组与11、13、15月龄组成骨细胞内[Ca2+]i有显著性差异(P<0.05),5、7、9月龄组与各组相比均无差异(P>0.05).应用全细胞膜片钳技术发现刺激电压为+10 mV时,2、7、13月龄组鼠ICa分别为(-392.77±97.07)pA、(-330.33±33.86)pA和(-287.68±71.01)pA,13月龄组鼠与2月龄组鼠相比,ICa明显降低(P<0.05),而7月龄组鼠与2月龄组鼠和13月龄组鼠相比,ICa均没有明显差异(P>0.05).结论不同月龄大鼠成骨细胞内[Ca2+]i存在差异,其机制可能与细胞膜上钙通道活性改变相关. 相似文献