全文获取类型
收费全文 | 48935篇 |
免费 | 4630篇 |
国内免费 | 1111篇 |
专业分类
耳鼻咽喉 | 247篇 |
儿科学 | 2026篇 |
妇产科学 | 1222篇 |
基础医学 | 3043篇 |
口腔科学 | 1677篇 |
临床医学 | 12560篇 |
内科学 | 4468篇 |
皮肤病学 | 291篇 |
神经病学 | 4190篇 |
特种医学 | 1617篇 |
外国民族医学 | 9篇 |
外科学 | 7383篇 |
综合类 | 4740篇 |
现状与发展 | 1篇 |
一般理论 | 5篇 |
预防医学 | 2801篇 |
眼科学 | 651篇 |
药学 | 3926篇 |
65篇 | |
中国医学 | 2344篇 |
肿瘤学 | 1410篇 |
出版年
2024年 | 115篇 |
2023年 | 1069篇 |
2022年 | 1723篇 |
2021年 | 2366篇 |
2020年 | 2385篇 |
2019年 | 2446篇 |
2018年 | 2291篇 |
2017年 | 2239篇 |
2016年 | 2069篇 |
2015年 | 1937篇 |
2014年 | 3627篇 |
2013年 | 4376篇 |
2012年 | 2667篇 |
2011年 | 2927篇 |
2010年 | 2342篇 |
2009年 | 2113篇 |
2008年 | 2354篇 |
2007年 | 2080篇 |
2006年 | 1874篇 |
2005年 | 1571篇 |
2004年 | 1326篇 |
2003年 | 1154篇 |
2002年 | 983篇 |
2001年 | 886篇 |
2000年 | 700篇 |
1999年 | 633篇 |
1998年 | 516篇 |
1997年 | 516篇 |
1996年 | 411篇 |
1995年 | 346篇 |
1994年 | 346篇 |
1993年 | 274篇 |
1992年 | 265篇 |
1991年 | 216篇 |
1990年 | 148篇 |
1989年 | 163篇 |
1988年 | 137篇 |
1987年 | 143篇 |
1986年 | 124篇 |
1985年 | 156篇 |
1984年 | 125篇 |
1983年 | 101篇 |
1982年 | 110篇 |
1981年 | 98篇 |
1980年 | 73篇 |
1979年 | 37篇 |
1978年 | 28篇 |
1977年 | 23篇 |
1976年 | 30篇 |
1975年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 203 毫秒
11.
Matthieu Talagas Nicolas Lebonvallet Franois Berthod Laurent Misery 《Experimental dermatology》2019,28(12):1466-1469
Recent years have brought an enhanced understanding of keratinocyte contribution to cutaneous nociception. While intra‐epidermal nerve endings were classically considered as the exclusive transducers of cutaneous noxious stimuli, it has now been demonstrated that epidermal keratinocytes can initiate nociceptive responses, like Merkel cells do for the innocuous mechanotransduction. In the light of recent in vivo findings, this article outlines this paradigm shift that points to a not yet considered population of sensory epidermal cells. 相似文献
12.
目的:分析抑郁症与不明原因胸痛间的关联性及其可能机制,为临床疾病的治疗提供参考依据。方法:纳入2012年6月至2014年5月四川省南充精神卫生中心精神科收治的不明原因胸痛患者35例,作为观察组,另选取35例来院进行常规体检的健康志愿者作为对照组,比较两组的抑郁量表评分、抑郁症发生率、血清C反应蛋白(CRP)、白细胞介素6(IL-6)、五羟色胺(5-HT)及外周血中的CD4+、CD8+含量。结果:与对照组比较,观察组的CRP、IL-6、5-HT、CD4+均低于对照组;且观察组的CD8+、抑郁症发生率(31.43%)、轻中度抑郁及重度抑郁患者比例均高于对照组水平,组间对比差异显著(P<0.05)。结论:抑郁症与不明原因胸痛存在一定相关性,推断可能与CRP、5-HT、IL-6等细胞因子有关,也可能与免疫抑制过程有关,在临床诊治中需引起重视。 相似文献
13.
14.
Cost‐Effectiveness and Cost‐Utility Analysis of Spinal Cord Stimulation in Patients With Failed Back Surgery Syndrome: Results From the PRECISE Study
下载免费PDF全文
![点击此处可从《Neuromodulation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Furio Zucco MD Roberta Ciampichini MSc Angelo Lavano MD Amedeo Costantini MD Marisa De Rose MD Paolo Poli MD Gianpaolo Fortini MD Laura Demartini MD Enrico De Simone MD Valentino Menardo MD Piero Cisotto MD Mario Meglio MD Luciana Scalone PhD Lorenzo G. Mantovani DSc 《Neuromodulation》2015,18(4):266-276
15.
Interstitial cystitis/bladder pain syndrome (IC/BPS) and vulvodynia are chronic pain syndromes that appear to be intertwined from the perspectives of embryology, pathology and epidemiology. These associations may account for similar responses to various therapies. 相似文献
16.
Dan-Feng Xu Bing Wu Jin-Xin Wang Jian Yu Jian-Xin Xie 《World Journal of Clinical Cases》2021,9(5):1096-1102
BACKGROUNDGuillain-Barré syndrome (GBS) is a rare disorder that typically presents with ascending weakness, pain, paraesthesias, and numbness, which mimic the findings in lumbar spinal stenosis. Here, we report a case of severe lumbar spinal stenosis combined with GBS.CASE SUMMARYA 70-year-old man with a history of lumbar spinal stenosis presented to our emergency department with severe lower back pain and lower extremity numbness. Magnetic resonance imaging confirmed the diagnosis of severe lumbar spinal stenosis. However, his symptoms did not improve postoperatively and he developed dysphagia and upper extremity numbness. An electromyogram was performed. Based on his symptoms, physical examination, and electromyogram, he was diagnosed with GBS. After 5 d of intravenous immunoglobulin (0.4 g/kg/d for 5 d) therapy, he gained 4/5 of strength in his upper and lower extremities and denied paraesthesias. He had regained 5/5 of strength in his extremities when he was discharged and had no symptoms during follow-up.CONCLUSIONGBS should be considered in the differential diagnosis of spinal disorder, even though magnetic resonance imaging shows severe lumbar spinal stenosis. This case highlights the importance of a careful diagnosis when a patient has a history of a disease and comes to the hospital with the same or similar symptoms. 相似文献
17.
《Diagnostic and interventional imaging》2020,101(9):555-564
PurposeThe purpose of this study was to determine whether computed tomography (CT)-based machine learning of radiomics features could help distinguish autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma (PDAC).Materials and MethodsEighty-nine patients with AIP (65 men, 24 women; mean age, 59.7 ± 13.9 [SD] years; range: 21–83 years) and 93 patients with PDAC (68 men, 25 women; mean age, 60.1 ± 12.3 [SD] years; range: 36–86 years) were retrospectively included. All patients had dedicated dual-phase pancreatic protocol CT between 2004 and 2018. Thin-slice images (0.75/0.5 mm thickness/increment) were compared with thick-slices images (3 or 5 mm thickness/increment). Pancreatic regions involved by PDAC or AIP (areas of enlargement, altered enhancement, effacement of pancreatic duct) as well as uninvolved parenchyma were segmented as three-dimensional volumes. Four hundred and thirty-one radiomics features were extracted and a random forest was used to distinguish AIP from PDAC. CT data of 60 AIP and 60 PDAC patients were used for training and those of 29 AIP and 33 PDAC independent patients were used for testing.ResultsThe pancreas was diffusely involved in 37 (37/89; 41.6%) patients with AIP and not diffusely in 52 (52/89; 58.4%) patients. Using machine learning, 95.2% (59/62; 95% confidence interval [CI]: 89.8–100%), 83.9% (52:67; 95% CI: 74.7–93.0%) and 77.4% (48/62; 95% CI: 67.0–87.8%) of the 62 test patients were correctly classified as either having PDAC or AIP with thin-slice venous phase, thin-slice arterial phase, and thick-slice venous phase CT, respectively. Three of the 29 patients with AIP (3/29; 10.3%) were incorrectly classified as having PDAC but all 33 patients with PDAC (33/33; 100%) were correctly classified with thin-slice venous phase with 89.7% sensitivity (26/29; 95% CI: 78.6–100%) and 100% specificity (33/33; 95% CI: 93–100%) for the diagnosis of AIP, 95.2% accuracy (59/62; 95% CI: 89.8–100%) and area under the curve of 0.975 (95% CI: 0.936–1.0).ConclusionsRadiomic features help differentiate AIP from PDAC with an overall accuracy of 95.2%. 相似文献
18.
19.