肝癌患者过继免疫与栓塞化疗治疗前后免疫功能变化

对46例原发性肝癌患者LAK／IL－2肝动脉灌注与栓塞化符合用及单纯栓塞化行治疗前后机体免疫状态，即T淋巴细胞亚群，可溶性白细胞介素-2受体（sIL－2R），TNF及自身LAK细胞活性进行了比较研究。结果表明，治疗前患者T淋巴细胞亚群CD3、CD4明显低于正常对照组。CD3升高，CD4／CD8比值下降；sIL－2R及TNF水平明显高于正常对照组。治疗后，LAK／IL－2肝动脉灌注即过继免疫与栓塞化疗合用组，T淋巴细胞亚群CD3、CD4升高（P＜0.01），CD3下降（P＜0．01）、CD4／CD8比值升高（P＜0．01）sIL－2R水平下降（P＜0.01），TNF水平亦下降，自身LAK细胞活性增强（P＜0.01）；单纯栓塞化疗组上述指标无显著变化。     

气滞胃痛冲剂药理学实验研究

气滞胃痛冲剂ig,能明显抑制小鼠胃排空和小肠推进作用,减少胃液分泌,降低胃液酸度及胃蛋白酶活性,增强家兔在体肠蠕动强度,对大鼠幽门结扎型溃疡有明显的保护作用,还有明显的镇痛作用。     

二子阳宝的药理实验研究

二子阳宝能明显提高去势雄性小鼠副性器官和提肛肌指数；明显增加性交配功能；并能增强肾阳虚小鼠的耐缺氧，抗疲劳能力。     

生命1号健脑强身及促骨生长的实验研究

采用水迷宫法、穿梭箱法、避暗法、跳台法观察了生命1号对小鼠学习、记忆、巩固的影响。灌胃给生命1号可改善东莨菪碱、樟柳碱致小鼠记忆获得障碍。生命1号能明显提高单核细胞吞噬功能，显著增加小鼠血清溶血素的含量，促进T淋巴细胞的转化。除此之外，还能明显地增加阳虚大鼠股骨的重量、长度、直径及皮质厚度；提高血清钙、磷水平；降低血清碱性磷酸酶的含量，具有促进骨骼生长的作用。     

黄芪毛状根对造血系统功能的作用

本实验研究了黄芪毛状根对动物造血系统的作用,采用灌服给予黄芪毛状根5～20 g/kg,每日1次,连续5～12天,可提高失血性贫血小鼠的红细胞数、网织红细胞数,增加溶血性贫血小鼠的红细胞数、血红蛋白值、红细胞压积值,可对抗环磷酰胺、X射线所致小鼠的白细胞数和骨髓有核细胞数的下降。实验提示黄芪毛状根有促进造血系统功能的作用,其作用基本上与天然黄芪相似。     

The vestibulo-collic reflex

Until now there has no been no simple, reliable clinical test that assesses the function of the otolith organs. However, recent work has suggested the occurrence of an easily identifiable electromyographic (EMG) waveform in isometrically contracting sternomastoid muscles in response to loud clicks. This is thought to represent an otolith evoked disynaptic reflex. Equipment routinely used for evoked response audiometry (ERA) has been adapted to investigate this response. A short latency (8 ms) positive-negative EMG waveform has been recorded in 31 of 32 normal subjects. The latency of the positive peak (P1) is 11.7 ms ( sd = 0.89), and the negative peak (N1) is 20.5 ms ( sd = 1.89). It is predominantly ipsilateral, although a contralateral response was present in 35.5%. The response has also been recorded in three patients with a severe unilateral sensorineural hearing loss and normal caloric responses, and in a patient undergoing cochlear implantation for profound bilateral sensorineural hearing loss. Further work is required to delineate the value of this technique in investigating vestibular lesions.     

Somatic growth and renal function after unilateral nephrectomy for Wilms' tumor

Solitary kidneys in renal donors and patients who have undergone unilateral nephrectomy for malignant disease have been reported to undergo hyperfiltration injury. This study was undertaken to evaluate the somatic growth and development of followed-up patient after Wilms' tumor to evaluate their renal function and identify any evidence of injury in the remaining kidney. The growth and development of all the children was found to be normal, as was DTPA clearance. Microalbuminuria in 24-h urinary collections was detected in 84% of the patients, indicating evidence of hyperfiltration injury. This study highlights the need for close monitoring of the renal function of long-term follow-up patients after Wilms' tumor in addition to the routine monitoring for tumor recurrence. Accepted: 26 May 1998     

32例生长激素缺乏症患者的心功能探讨

目的评价原发性生长激素缺乏症患者的心功能状况，以探讨生长激素对心功能的作用。方法用平衡法核素心血池显像技术及运动试验，对３２例儿童期诊断为垂体发育不良所致的生长激素缺乏症患者及１０例正常健康儿童进行心功能评价。结果３２例患者左心室总体射血分数和左心室舒张末期高峰充盈率明显低于正常健康组小儿；２５例（７８％）患者局部心室收缩功能降低；１５例（４７％）患者左心室总体收缩或（和）舒张功能降低；２５例（７８％）运动试验后出现心率改变、轻度ＳＴ段降低及Ｔ波改变。结论大部分生长激素缺乏症者在没有生长激素治疗的情况下，存在不同程度的心室收缩和舒张功能损害及心肌缺血和劳损。生长激素缺乏症者应尽早检测心功能、尽早给予生长激素治疗以预防成年后心血管疾病的发生     

肝癌栓塞化疗后免疫治疗临床观察

目的探讨肝癌栓塞化疗后，患者生存时间与机体免疫功能状态间的关系。方法１０８例肝癌患者随机分为甲、乙、丙三组。进行单纯肝动脉栓塞化疗及栓塞化疗后分别给予免疫和中药治疗。结果近期有效率分别为５８．３％、８３．３％和８０．６％。三年生存率分别为２８．５％、３９．１％和４７．３％。中位生存时间分别为１１、１７和１５个月。有显著性差异。治疗后免疫功能检查，单纯栓塞化疗者机体免疫力低下。而用生物调节剂和中药治疗者则机体免疫能力增强。结论肝癌患者生存时间与机体免疫功能强弱有关，免疫力增强，则生存时间相对延长