下颌骨边缘性骨髓炎208例临床总结

目的:分析下颌骨边缘性骨髓炎患者的病因及最佳治疗方法。方法:对过去10年中我们收治的208例下颌骨边缘性骨髓炎患者进行回顾性归类和统计。结果:208例全部治愈,其中手术191例,非手术17例。结论:早期诊断、及时清除病灶对下颌骨边缘性骨髓炎患者有重要意义。     

食管良性病变病理和预后的研究

目的探讨食管良性病变病理组织学类型和鳞癌及重度异型增生的发生率。方法对1997～2000年131例食管良性病变患者进行内镜形态观察与活检病理学检查,另取同期内镜检查食管正常者236例作为对照组。比较病理组织学变化,随访至2004年底,比较两组食管鳞癌和重度异型增生的发生率及相对危险度(RR)。结果食管良性病变根据内镜形态分为炎症糜烂型病变69例,平坦凹陷型病变21例和隆起型病变41例。病理组织学检查:正常或炎症上皮33例(25.19%),良性增生58例(44.27%)和轻中度异型增生40例(30.54%);对照组中,正常上皮181例(76.69%),良性增生55例(23.31%),无异型增生者。食管良性病变组中良性增生和轻中度异型增生明显高于对照组,而正常或炎症上皮明显低于对照组。食管良性病变组随访708人/年,鳞癌和重度异型增生分别发生21例和14例,共35例(4.94%)。对照组随访1315人/年,鳞癌和重度异型增生各发生1例,共2例(0.15%),食管良性病变组明显高于对照组。在食管良性病变中,良性增生和轻中度异型增生者鳞癌和重度异型增生发生率明显高于正常或炎症上皮。结论含有良性增生和轻中度异型增生的食管良性病变是食管鳞癌癌前状态。     

Malignancy Rate and Malignancy Risk Assessment in Different Lesions of Uncertain Malignant Potential in the Breast (B3 Lesions): An Analysis of 192 Cases from a Single Institution

BackgroundThe question of how to deal with B3 lesions is of emerging interest.MethodsIn the breast diagnostics of 192 patients between 2009 and 2016, a minimally invasive biopsy revealed a B3 lesion with subsequent resection. This study investigates the malignancy rate of different B3 subgroups and the risk factors that play a role in obtaining a malignant finding.ResultsThe distribution of B3 lesions after minimally invasive biopsy was as follows: atypical ductal hyperplasia (ADH), 7.3%; flat epithelial atypia (FEA), 7.8%; lobular neoplasia (LN), 7.8%; papilloma (Pa), 49.5%; phylloidal tumour (PT), 8.9%; radial sclerosing scar (RS), 3.1%; mixed findings, 10.4%; and other B3 lesions, 5.2%. Most B3 lesions were detected by stereotactic vacuum-assisted biopsy (44.3%), 36.5% by ultrasound-assisted biopsy, and 19.3% by magnetic resonance imaging-assisted biopsy. Most B3 lesions (55.2%) were verified by surgical resection, whereas 30.7% were downgraded to a benign lesion. About 14.1% of the cases were upgraded to malignant lesions, 9.4% to ductal carcinoma in situ and 4.7% to invasive carcinoma. In relation to individual B3 lesions, the following malignancy rates were found: 28.6% (ADH), 13.3% (FEA), 33.3% (LN), 12.6% (Pa), 5.9% (PT), and 0% (RS). The most important risk factor was increasing age. Postmenopausal status was considered an increased risk for an upgrade (p = 0.015). A known malignancy in the ipsilateral breast was a significant risk factor for a malignant upgrade (p = 0.003).ConclusionIncreasing knowledge about B3 lesions allows us to develop a “lesion-specific” therapy approach in the heterogeneous group of B3 lesions, with follow-up imaging for some lesions with less malignant potential and concordance with imaging or further surgical resection in cases of disconcordance with imaging or higher malignant potential.     

结直肠癌前病变中医病机探讨

在癌毒病机理论的指导下,提出结直肠癌前病变的共性病机为湿热毒蕴,脾气亏虚.湿、热之邪在脾虚的基础上产生并相互胶结于肠腑,日久内生癌毒.脾气亏虚是结直肠癌前病变发生的根本病机,湿热蕴结是其发展条件,癌毒内生是癌变的关键所在.结合内镜下病理分级,根据癌毒内生与否可将结直肠癌前病变的演变过程分为无癌毒期及癌毒期.癌毒致病的过...     

Hamartochondroma Pleural Lesion Mimicking Liposarcoma: A Case Report

Heterogeneous masses developing in the pleural cavity are most often malignant and can pose diagnostic challenges. Fibrous tumors of the pleura, liposarcoma, thymoma or lipoma most frequently affect this anatomic area. Surgical exploration and resection are often mandatory to make the definitive diagnosis. We report the case of a 54-year-old women who presented with an epigastric and right sub costal pain. A complete preoperative workup revealed a large tissular and fatty mass in the right costo-diaphragmatic angle suggestive of liposarcoma. Surgical resection resulted in the surprising diagnosis of hamartochondroma.     

彩色多普勒超声诊断精索病变的价值

目的探讨彩色多普勒超声在精索病变诊断与鉴别诊断中的价值。方法分别在阴囊、阴囊根部及腹股沟部进行超声扫查,观察精索径线的大小、声像图表现及血流情况。结果精索静脉曲张35例、精索炎36例、精索鞘膜积液25例及精索肿瘤3例,各有其声像图特征表现。结论彩色多普勒超声对于精索疾病的诊断与鉴别诊断,具有重要的临床价值。     

根管治疗术在牙周牙髓联合病变治疗中的应用

目的：探讨根管治疗术在牙周牙髓联合病变治疗中的重要性。方法：对235例356个牙周病引起牙周牙髓联合病变的患牙进行分级并分成2组,实验组采用根管治疗术和牙周系统治疗的联合治疗,对照组只采用牙周系统治疗。观察治疗后1年的临床疗效。结果：治疗1年后,实验组临床疗效好于对照组,有显著性差异（P〈0．01）。结论：根管治疗术的应用在牙周病引起的牙周牙髓联合病变的治疗中具有重要意义。     

肾衰泻浊汤对慢性肾衰大鼠肾小管间质损伤的作用

目的 :探讨肾衰泻浊汤对慢性肾衰模型大鼠肾小管间质损伤的抑制作用。方法 :将 5 0只由腺嘌呤诱导慢性肾衰的大鼠模型分为 5组 ,4个治疗组予以肾衰泻浊汤防治 ,分析对比各组大鼠血THP浓度、尿NAG排泄量及肾组织PCNA阳性细胞数 ,评定肾小管间质病理损伤情况。结果 :各治疗组大鼠血THP浓度明显提高 ,尿NAG排泄量及肾组织PCNA阳性细胞数目明显降低 (P <0 .0 5 ) ,肾小管间质病理损伤有所改善。且血THP与Scr ,BUN呈显著负相关 ,尿NAG与SCr呈显著正相关。结论 :肾衰泻浊汤防治慢性肾衰的机制可能与抑制肾脏细胞增殖、减轻肾小管间质的病理损伤有关。     

应用药物球囊与药物洗脱支架治疗左主干再狭窄分叉病变的对比研究

目的 对比应用药物球囊(DCB)血管成形术与再次植入药物洗脱支架(DES)治疗左主干再狭窄分叉病变对患者的长期影响.方法 回顾性纳入2014年10月-2018年10月在天津市胸科医院因左主干再狭窄分叉病变行介入治疗的患者48例,其中DCB组24例,DES组24例,术前、术后均行冠状动脉造影定量分析,39例(81.3％)...     

手十二井穴刺络放血法对MCAO模型大鼠大脑皮层c-fos蛋白表达的影响

目的 从脑内c-fos蛋白表达的角度观察井穴放血法对急性缺血性脑损伤的脑保护作用。方法 以凝结法阻断大鼠一侧大脑中动脉造成急性局灶性缺血性脑损伤模型(MCAO)，用免疫组织化学法观察缺血区皮层脑组织c-fos阳性细胞的表达变化及施加手十二井穴放血法后对其的干预治疗作用。结果 急性缺血性脑损伤可快速诱导c-fos蛋白在皮层缺血区脑组织的表达，其表达有随缺血时间延长逐渐增多的趋势，而缺血后即刻施加井穴放血的干预治疗．在1h、3h、6h、24h各缺血时间段均可明显上调缺血区皮层脑组织c-fos蛋白的表达水平。结论 c-fos蛋白表达既与缺血的严重程度有关．也反应神经元的应激反应能力，脑缺血能诱导c-fos蛋白的逐渐表达，提示脑的缺血性损伤可应激性地增强神经细胞对缺血、缺氧的耐受和适应能力。而早期施加井穴刺络放血疗法能进一步增强c-fos蛋白表达，提高神经细胞的应激能力，从而提高缺血区脑组织的抗损伤修复能力，减缓神经细胞凋亡，抵抗缺血性脑损害的进一步发展，产生有效的脑保护作用，表明井穴放血法对中风早期有一定的急救作用。