Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery

Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, hyperbaric oxygen therapy, or their combination, in rat models of spinal cord contusion injury. The combined treatment was more effective in improving hindlimb motor function than either treatment alone; injured spinal tissue showed a greater number of neurite-like structures in the injured spinal tissue, somatosensory and motor evoked potential latencies were notably shorter, and their amplitudes greater, after combination therapy than after monotherapy. These findings indicate that Schwann cell transplantation combined with hyperbaric oxygen therapy is more effective than either treatment alone in promoting the recovery of spinal cord in rats after injury.     

An ethical rationale for perinatal palliative care

Perinatal palliative care has grown out of both an historical necessity in attending to babies in the NICU that face difficult odds of survival, the increasing technology that may avail life-extending, yet technology-dependent, care, and the growth of fetal diagnostic and treatment centers. This review looks ta the history and ethical rationale for making available services from Pediatric and Perinatal Palliative Care to families in the prenatal and postnatal periods caring for a loved one with life-limiting circumstances.     

ECMO辅助肺移植围术期的护理配合

目的总结体外膜肺氧合(ECMO)辅助肺移植手术的护理配合经验。方法对45例终末期肺病伴肺动脉高压的患者进行充分的术前准备,在肺移植术中应用了ECMO辅助转流,其中单肺移植21例,双肺移植24例。所有患者行右侧股动静脉置管ECMO辅助转流。转流期间维持激活凝血时间(ACT)160～200s,ECMO流量控制在1.8～2.5L/(m2.min)。术中严密细致地做好各项监测及护理配合。受者术后在氧合和血流动力学平稳后撤除ECMO。结果所有受者手术过程顺利,41例在移植术后顺利撤除ECMO;4例术后继续使用ECMO支持。结论ECMO可安全有效地用于肺移植术中的呼吸循环辅助,提高肺移植手术的成功率。充分的术前准备、术中全面的监测、娴熟的手术配合和合理的供肺保存是手术成功的关键因素之一,台上、台下严格的无菌技术操作,消毒隔离制度的管理是手术成功的保证。     

三维适形放疗联合高压氧治疗恶性上腔静脉阻塞症的相关研究

目的：探讨三维适形放疗联合高压氧提高恶性上腔静脉阻塞症治疗疗效的可能性。方法：采用随机分组的方法将恶性肿瘤合并上腔静脉阻塞症的患者分为单纯放疗组（单放组）与放疗加高压氧组（联合组），其中联合组和单放组各23例。结果：联合组有效率为82．6％，单放组有效率65．21％，两组之间的差异有统计学意义（P〈0．05）。两组患者治疗中不良反应差异有统计学意义，联合组优于单放组。结论：三维适形放疗联合高压氧治疗可提高恶性上腔静脉阻塞症的疗效，且不良反应有所减轻。