全文获取类型
收费全文 | 175680篇 |
免费 | 14587篇 |
国内免费 | 7045篇 |
专业分类
耳鼻咽喉 | 1258篇 |
儿科学 | 3176篇 |
妇产科学 | 2710篇 |
基础医学 | 32295篇 |
口腔科学 | 4059篇 |
临床医学 | 13497篇 |
内科学 | 26473篇 |
皮肤病学 | 3355篇 |
神经病学 | 14084篇 |
特种医学 | 3129篇 |
外国民族医学 | 46篇 |
外科学 | 12277篇 |
综合类 | 26276篇 |
现状与发展 | 40篇 |
一般理论 | 12篇 |
预防医学 | 9918篇 |
眼科学 | 2436篇 |
药学 | 23702篇 |
30篇 | |
中国医学 | 5769篇 |
肿瘤学 | 12770篇 |
出版年
2024年 | 264篇 |
2023年 | 2219篇 |
2022年 | 3997篇 |
2021年 | 6485篇 |
2020年 | 5271篇 |
2019年 | 5329篇 |
2018年 | 5375篇 |
2017年 | 5749篇 |
2016年 | 5854篇 |
2015年 | 6568篇 |
2014年 | 10162篇 |
2013年 | 12360篇 |
2012年 | 10597篇 |
2011年 | 12012篇 |
2010年 | 9706篇 |
2009年 | 9409篇 |
2008年 | 9243篇 |
2007年 | 9032篇 |
2006年 | 8229篇 |
2005年 | 7384篇 |
2004年 | 6455篇 |
2003年 | 5550篇 |
2002年 | 4380篇 |
2001年 | 3716篇 |
2000年 | 3308篇 |
1999年 | 2844篇 |
1998年 | 2715篇 |
1997年 | 2505篇 |
1996年 | 2203篇 |
1995年 | 2013篇 |
1994年 | 1788篇 |
1993年 | 1573篇 |
1992年 | 1353篇 |
1991年 | 1253篇 |
1990年 | 1032篇 |
1989年 | 918篇 |
1988年 | 786篇 |
1987年 | 702篇 |
1986年 | 651篇 |
1985年 | 1065篇 |
1984年 | 1027篇 |
1983年 | 678篇 |
1982年 | 769篇 |
1981年 | 607篇 |
1980年 | 519篇 |
1979年 | 366篇 |
1978年 | 313篇 |
1977年 | 254篇 |
1976年 | 254篇 |
1975年 | 170篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
42.
43.
A growing body of data suggests that therapies based on Toll-like receptors (TLR) targeting, in particular TLR4, holds promise in curing autoimmune and inflammatory pathologies still lacking specific treatment, included several rare diseases. While TLR4 activators (agonists) have already found successful clinical application as vaccine adjuvants, the use of TLR4 blockers (antagonists) as antisepsis agents or as agents against inflammatory diseases (including arthritis, multiple sclerosis, neuroinflammations) and cancer is still at a preclinical phase of development. This minireview focuses on recent achievements on the development of TLR4 modulators based on lipid A structure simplification, in particular on compounds having disaccharide or monosaccharide structures. As the TLR4 activity of natural TLR4 ligands (lipopolysaccharide, LPS and its biologically active part, the lipid A) depends on both the structure of endotoxin aggregates in solution and on single-molecule interaction with MD-2 and CD14 receptors, the rational design of TLR4 modulators should in principle take into account both these factors. In the light of the most recent advances in the field, in this minireview we discuss the structure–activity relationship in simplified lipid A analogs, with cationic or anionic amphiphilic structures. 相似文献
44.
45.
46.
《Mayo Clinic proceedings. Mayo Clinic》2019,94(7):1321-1329
Immune checkpoint inhibitors are molecules that increase the endogenous immune response against tumors. They have revolutionized the field of oncology. Since their initial approval for the treatment of advanced melanoma, their use has expanded to the treatment of several other advanced cancers. Unfortunately, immune checkpoint inhibitors have also been associated with the emergence of a new subset of autoimmune-like toxicities, known as immune-related adverse events. These toxicities differ depending on the agent, malignancy, and individual susceptibilities. Although the skin and colon are most commonly involved, any organ may be affected, including the liver, lungs, kidneys, and heart. Most of these toxicities are diagnosed by excluding other secondary infectious or inflammatory causes. Corticosteroids are commonly used for treatment of moderate and severe immune-related adverse events, although additional immunosuppressive therapy may occasionally be required. The occurrence of immune-related toxicities may require discontinuation of immunotherapy, depending on the specific toxicity and its severity. In this article, we provide a focused review to familiarize practicing clinicians with this important topic given that the use of immune checkpoint inhibitors continues to increase. 相似文献
47.
48.
《Bulletin du cancer》2019,106(4):389-394
49.
Khaled Adil Marija Popovic Fabio L. Cury Sergio L. Faria Marie Duclos Luis Souhami 《Practical radiation oncology》2019,9(1):24-28
Purpose
This study aimed to investigate 3 planning target volume (PTV) margin expansions and determine the most appropriate volume to be used in bladder preservation therapy when using daily cone beam computed tomography (CBCT). We aimed to establish whether a smaller PTV expansion is feasible without risking geographical miss.Methods and materials
The study included patients with bladder cancer who were treated with a hypofractionated course of radiation therapy delivered with intensity modulated radiation therapy. The clinical target volume (CTV) was the whole empty bladder, and the PTV consisted of a 1.5-cm margin around the bladder (PTV1.5 cm). Patients underwent daily CBCT imaging before treatment to assess the bladder volume and ensure accurate positioning. We investigated 2 additional smaller PTV margin expansions to determine the most appropriate volume to be used with CBCT as a daily image guided radiation therapy modality. These margins were created retrospectively on every CBCT. The first additional volume was a uniform PTV margin of the surrounding 1 cm (PTV1 cm). When considering that the majority of the internal bladder movement was due to the variation in filling that occurs in the superior and anterior directions, a second volume of an anisotropic PTV margin with a 1.5-cm superior/anterior and 1 cm in other directions (PTV1/1.5 cm) was created. We recorded the frequency and measured the volume of bladder falling out of each PTV based on the daily CBCT.Results
For the purpose of this study, we considered an arbitrary 5 cm3 of CTV falling out of the designated PTV as a clinically significant volumetric miss. The frequency of such a miss when applying the uniform PTV1 cm was 1%. However, when applying the uniform PTV1.5 cm and anisotropic PTV1/1.5 cm margins, the frequency was 0.5% and 0.5%, respectively.Conclusions
The anisotropic PTV expansion of 1.5 cm superiorly and anteriorly and 1 cm in all other directions around the bladder (CTV) provides a safe PTV approach when daily CBCT imaging is used to localize an empty bladder. 相似文献50.