选择性激光小梁成形术治疗各类型开角型青光眼临床疗效的研究

目的观察选择性激光小梁成形术(selectlasertrabecularplasty,SLT)治疗各类型开角型青光眼(openangleglaucoma,OAG)降低眼内压的临床疗效和临床反应。方法对27例(52眼)多种类型开角型青光眼进行SLT治疗。所用设备为CoherentSelecta7000倍频Q-开关NdYAG双频激光仪。80个非重叠激光斑打击在颞侧180°范围小梁网,能量0.4～1.0mJ,激光斑400μm。术后观察眼内压和前房反应,时间为1d,1,6mo,1a。全部患者定期检查视力、裂隙灯、眼底镜、房角镜、视野(Octopus视野仪)、海德堡共焦激光断层扫描仪,(HRT-ⅡONH)和眼前节生物超声(UBM)检查。结果患者术前眼压平均(26.87±2.6)mmHg,不同时期的眼压大部分改善,术后1a为(20.21±3.4)mmHg,下降幅度为(6.66±2.8)mmHg,相当于下降24.78%,有3眼为高眼压症,没有明显降压效果出现。2眼为发育性青光眼,术后5d内降眼压效果明显,但10d左右眼压回升到接近术前水平转为手术治疗。部分病例仍需配合局部降眼压药。视力、C/D比、房角镜无明显改变。1a视野检查,9眼有改善。结论SLT治疗多种类型开角型青光眼安全有效,没有明显副作用和并发症,是治疗开角型青光眼的有效方法之一。     

三环类环氧合酶-2选择性抑制剂的构效关系

按照中心环的结构分类综述三环类环氧合酶-2(COX-2)选择性抑制剂的构效关系。三环类COX-2选择性抑制剂是目前非甾体抗炎药中研究最多、也是最富有成果的一类化合物。     

高效抗逆转录病毒疗法相关性代谢并发症研究进展

高效抗逆转录病毒疗法 (HAART)使人免疫缺陷病毒 (HIV)感染的发病率及病死率明显降低,但常引起代谢并发症,包括脂肪代谢障碍、血脂异常、高血糖、高乳酸血症及骨质疏松等,机制未完全阐明。有报道在接受HAART的HIV阳性病人,提前发生冠心病及心肌梗死的危险性上升。     

Basis of selection of first and second line highly active antiretroviral therapy for HIV/AIDS on genetic barrier to resistance: a literature review

The effectiveness of combination antiretroviral therapy (cART) continues to improve as treatment choices expand with the development of new antiretroviral agents and regimens. However, the successful long-term treatment of HIV/AIDS is under threat from the emergence of drug-resistant strains to multiple agents and entire drug classes.     

Challenges posed to the European pharmaceutical regulatory system by highly personalized medicines

The European pharmaceutical regulatory system has not yet been challenged by issues related to highly personalized medicines such as those to be found with active substances that affect RNA biochemistry. We review the current status of RNA-based pharmacology and present three possible case histories. The implications for the European pharmaceutical regulatory system are discussed.