An epidemiological study investigating the relationship between chorangioma and infantile hemangioma

Objectives

This study aimed to verify whether the infantile hemangioma (IH) incidence in children whose placentas showed a chorangioma is higher than in the general population, thus addressing the hypothesized relationship between chorangioma and IH.

Methods

All chorangioma diagnoses by the 1st Service of Pathology, University of Padova in 2004–2010, based on the analysis of placentas sent by the Department of Gynecological Sciences and Human Reproduction (University of Padova), were identified. Demographic, anamnestic and clinical data were collected from the mothers and newborns; mothers and pediatricians were interviewed by telephone within 1 year after birth to verify if any IH appeared. The incidence rates of IH and other adverse events (IUGR, preterm delivery, cesarean section, stillbirth) were compared with national and regional data, when available, or with estimates from the scientific literature.

Results

Thirty-eight chorangioma diagnoses were found. Of 33 infants born with a placenta affected by chorangioma, 18 infants had IH. The IH incidence recorded in our series (55%) was significantly higher than that recorded in national and regional surveys and in the scientific literature. Similar findings have been observed for the incidence of stillbirth, preterm birth and low birth weight incidence.

Conclusions

The IH incidence observed in our series appears to be significantly higher than that recorded among the general population, suggesting that an association between placental chorangioma and IH could exist which should be further verified in prospective studies.     

经皮球囊扩张椎体后凸成形术的临床应用

目的总结经皮球囊扩张椎体后凸成形术治疗胸腰椎疾病的临床特点和疗效。方法胸腰椎疾病28例,其中男性9例,女性19例;年龄56～84岁,平均年龄65岁;骨质疏松性椎体压缩骨折(OVCF)24例,椎体血管瘤(VH)4例。应用经皮球囊扩张椎体后凸成形术进行治疗,观察术后症状改善情况。结果 28例患者手术均顺利完成。患者术后疼痛症状均即刻消失,术后次日即下床活动。术后平均随访10个月,28例患者均恢复发病前生活方式,无疼痛;影像学检查,病椎高度无明显丢失,无并发症发生。结论经皮球囊扩张椎体后凸成形术是治疗胸腰椎疾病安全有效的一种方法。     

经皮射频消融治疗肝脏巨大血管瘤疗效观察

[摘 要] 目的 观察经皮射频消融术（PRFA）治疗肝脏巨大血管瘤（5 cm≤直径≤15 cm）的安全性及可行性。方法 回顾性分析2014年6月至2017年6月于达州市中心医院行手术治疗的78例肝巨大血管瘤患者的病例资料,其中42例行PRFA治疗（A组）,36例行传统开放手术治疗（B组）,通过比较手术时间、术中出血量、住院时间、住院费用、术后临床治愈率等指标,评价两种方案的疗效,观察两组患者在治疗过程中出现的不良反应或并发症,评估治疗安全性。结果 所有患者在治疗过程中均未发生严重的并发症,无一例死亡。两组术后1个月、6个月临床治愈率、术后并发症发生率无统计学差异（P > 0.05）;但两组在手术时间、术中出血量、住院时间、住院费用上存在差异,且具有统计学意义（P < 0.05）。结论 PRFA和传统开放手术治疗肝巨大血管瘤疗效相当,均具有较好的安全性;经皮射频消融术治疗肝巨大血管瘤具有微创、痛苦小、出血量少、手术时间短、住院费用低的优点。严格掌握手术适应证,选择个体化治疗方式,PRFA可为肝巨大血管瘤患者的治疗提供一种替代选择途径。     

Vertebral hemangiomas: diagnosis, management, natural history and clinicopathological correlates in 86 patients

BACKGROUND Vertebral hemangiomas are characterized by diverse clinical histories, radiological features, and results of surgical treatment. It still remains unclear how these differences in clinical behavior relate to pathological type.

METHODS A retrospective diagnostic, surgical, and histopathological study of 86 consecutive patients with various pathological types of vertebral hemangioma was performed to establish clinicopathological correlates.

RESULTS The study confirmed that differences exist in clinical course, appearance on imaging, and outcomes in pathological types of hemangiomas. Based on these findings the authors attempted to identify signs characterizing each group.

CONCLUSIONS Differences in clinical history and radiological features exist among pathological types of vertebral hemangiomas. These differences cannot precisely predict the type pathology before histologic examination, but do help us to understand the natural history of such lesions more fully.     

经结膜入路冷冻摘除眼眶肌圆锥内海绵状血管瘤

目的:探讨经结膜入路冷冻摘除肌圆锥内海绵状血管瘤的手术方法、手术技巧与手术并发症. 方法: 对术前诊断为眼眶海绵状血管瘤的41例患者,选择符合前路开眶条件的36例行结膜入路肌圆锥内海绵状血管瘤冷冻摘除术.记录术中手术时间,观察术中、术后并发症. 结果: 36例肿瘤均顺利地经膜入路进行完整的冷冻摘除,术后35例确诊为海绵状血管瘤,1例确诊为神经鞘瘤.每例海绵状血管瘤手术历时约20~25 min.术中、术后无永久性并发症. 结论:经结膜入路冷冻摘除肌圆锥内眼眶海绵状血管瘤是一种简便、快捷、安全、有效的微创术式,值得临床推广应用.     

Peritumoral fat-spared area is well correlated with the presence of temporal peritumoral enhancement in hepatic hemangioma in fatty liver

PURPOSE: To assess the relationship between temporal peritumoral enhancement and peritumoral focal fat sparing adjacent to hepatic hemangiomas. MATERIALS AND METHODS: On the basis of MRI and sonographic imaging follow-up, 51 hepatic hemangiomas were identified in 37 patients, who had both hepatic hemangiomas and focal fat-sparing areas in fatty liver. Among them, 36 tumors were associated with peritumoral focal fat spares. The association between the temporal peritumoral enhancement in the early arterial phase of dynamic MRI and peritumoral fat sparing in the same hemangioma was investigated. Furthermore, the configuration of the temporal peritumoral enhancement was correlated with that of the peritumoral focal fat-sparing area. We used Chi square and Fisher's exact test for statistic analysis. RESULTS: A total of 31 out of 36 hemangiomas (86.1%) showed both peritumoral focal fat spares and temporal peritumoral enhancement. The presence of temporal peritumoral enhancement is significantly related to that of peritumoral focal fat-sparing (P < 0.001). A total of 21 of the 31 tumors (67.7%) presented with similar configuration of the peritumoral focal fat-sparing area and temporal peritumoral enhancement area with respect to size and shape. The remaining 10 hemangiomas showed similar shape but slightly different size in these two imaging characteristics. CONCLUSION: Temporal peritumoral enhancement seen in hepatic hemangioma might be related to focal fatty sparing adjacent to the hemangiomas.     

Progesterone receptor expression in orbital cavernous hemangiomas

Orbital cavernous hemangiomas (OCH) have thick and highly cellular vascular walls. Ultrastructural studies have demonstrated the smooth muscle nature of these cells. Vascular neoplasms can modify their morphological and clinical features under hormonal stimulation. The purpose of the present study was to investigate the presence of smooth muscle markers and sex steroid receptors in 12 cases of OCH. Orbital cases were compared with cutaneous hemangiomas and subcutaneous angioleiomyomas. Smooth muscle actin (SMA) and desmin were localized in spindle cells of the vascular walls of all 12 cases studied. OCH showed immunohistochemical positivity with progesterone receptor (PR) antibody both in smooth muscular and in endothelial cells. For comparison, sex steroid receptors were studied in 10 cases of cutaneous cavernous hemangioma and in 10 cases of subcutaneous angioleiomyoma. PR was found in smooth muscle and endothelial cells of 6 out of 10 cases of subcutaneous angioleiomyoma and in none of the cases of cutaneous cavernous hemangioma. No positivity was obtained with estrogen receptor (ER) antibody in any of the cases tested. The present data suggest that OCH share morphological and immunohistochemical features with subcutaneous angioleiomyomas. Furthermore, immunohistochemical positivity with PR antibody indicates that OCH have to be added to the list of mesenchymal lesions that express sex steroid receptors. Received: 15 July 1999 / Accepted: 14 September 1999     

Treatment of cutaneous and deep vascular lesions with the Nd:YAG laser

This study intends to document and evaluate the first compiled experience in the treatment of both cutaneous and deep vascular lesions using the Nd:YAG laser. Thirty-eight patients were treated over a 5-year period from 1979 to 1984 using the Nd:YAG laser with FDA approval. Lesions included capillary, cavernous, combined capillary-cavernous hemangiomas, portwine stains, arteriovenous malformations, lymphangiomas, multiple telangiectasias, and one case of Klippel-Trenaunay-Webber syndrome. The number of treatments per patient ranged from one to four. Partial or complete resolution of these various lesions, as evidenced by a decrease in size, and/or normalization of pathologic cutaneous changes was noted in a majority of patients. While both the argon and CO2 lasers have been well studied in the treatment of cutaneous vascular lesions, this is the first compiled series reporting results using the Nd:YAG for such problems. The Nd:YAG laser represents an alternative modality in the treatment of cutaneous hemangiomas and introduces an efficacious method in the treatment of cavernous vascular lesions.     

普萘洛尔治疗婴幼儿血管瘤的研究进展

婴幼儿血管瘤是婴幼儿时期最常见的先天性良性血管内皮细胞增生性肿瘤。普萘洛尔为非选择性β受体阻断药,临床常用于治疗心律失常、心绞痛、高血压等,普萘洛尔对血管瘤治疗作用的意外发现,使国内外掀起了对这个经典老药研究的热潮。普萘洛尔对婴幼儿血管瘤的疗效在临床观察中得到了肯定,其安全性及安全剂量尚需要大规模样本对照研究做进一步评估。     

海绵窦海绵状血管瘤的影像诊断及病理特征分析

目的 探讨蝶鞍旁海绵状血管瘤（cavernous sinus hemangiomas,CSHAs）的影像学表现和病理特征,以提高影像诊断水平.方法 回顾性分析经手术及病理证实的20例CSHAs患者的病例资料,所有患者均行CT及MRI扫描,18例行MR扩散加权成像（DWI）,3例术前行数字减影血管造影（DSA）检查.结果 病灶呈“球状”、“分叶状”或“葫芦状”跨蝶鞍生长,体积较大,均为单发病灶.CT平扫为稍高密度灶,MRI扫描后T1WI呈等或稍低信号,T2WI呈明显高信号,CT及MR增强扫描呈均匀或不均匀显著强化.18例DWI呈等或稍低信号,3例DSA表现为静脉期于蝶鞍旁可见淡染色团块,而动脉期及毛细血管期均未见异常染色.结论 CSHAs的影像学表现具有一定特征性,有助于提高术前定位及定性诊断的准确率.