全文获取类型
收费全文 | 38340篇 |
免费 | 3119篇 |
国内免费 | 1443篇 |
专业分类
耳鼻咽喉 | 426篇 |
儿科学 | 856篇 |
妇产科学 | 437篇 |
基础医学 | 2860篇 |
口腔科学 | 1579篇 |
临床医学 | 4649篇 |
内科学 | 6766篇 |
皮肤病学 | 1165篇 |
神经病学 | 1662篇 |
特种医学 | 1734篇 |
外科学 | 2632篇 |
综合类 | 6658篇 |
现状与发展 | 10篇 |
一般理论 | 4篇 |
预防医学 | 5553篇 |
眼科学 | 926篇 |
药学 | 2660篇 |
29篇 | |
中国医学 | 1768篇 |
肿瘤学 | 528篇 |
出版年
2024年 | 146篇 |
2023年 | 802篇 |
2022年 | 1689篇 |
2021年 | 1933篇 |
2020年 | 1857篇 |
2019年 | 1396篇 |
2018年 | 1323篇 |
2017年 | 1253篇 |
2016年 | 1481篇 |
2015年 | 1311篇 |
2014年 | 2572篇 |
2013年 | 2734篇 |
2012年 | 2351篇 |
2011年 | 2527篇 |
2010年 | 2066篇 |
2009年 | 1954篇 |
2008年 | 1857篇 |
2007年 | 1866篇 |
2006年 | 1586篇 |
2005年 | 1474篇 |
2004年 | 1162篇 |
2003年 | 1041篇 |
2002年 | 866篇 |
2001年 | 841篇 |
2000年 | 663篇 |
1999年 | 494篇 |
1998年 | 486篇 |
1997年 | 398篇 |
1996年 | 283篇 |
1995年 | 356篇 |
1994年 | 299篇 |
1993年 | 196篇 |
1992年 | 219篇 |
1991年 | 200篇 |
1990年 | 160篇 |
1989年 | 167篇 |
1988年 | 155篇 |
1987年 | 142篇 |
1986年 | 114篇 |
1985年 | 93篇 |
1984年 | 73篇 |
1983年 | 42篇 |
1982年 | 43篇 |
1981年 | 29篇 |
1980年 | 29篇 |
1979年 | 38篇 |
1978年 | 22篇 |
1977年 | 26篇 |
1976年 | 25篇 |
1975年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Treatment of posterior eye diseases is more challenging than the anterior segment ailments due to a series of anatomical barriers and physiological constraints confronted by drug delivery to the back of the eye. In recent years, concerted efforts in drug delivery have been made to prolong the residence time of drugs injected in the vitreous humor of the eye. Our previous studies demonstrated that poly(ortho ester) (POE) nanoparticles were biodegradable/biocompatible and were capable of long-term sustained release. The objective of the present study was to investigate the safety and localization of POE nanoparticles in New Zealand white rabbits and C57BL/6 mice after intravitreal administration for the treatment of chronic posterior ocular diseases. Two concentration levels of POE nanoparticles solution were chosen for intravitreal injection: 1.5?mg/ml and 10?mg/ml. Our results demonstrate that POE nanoparticles were distributed throughout the vitreous cavity by optical coherence tomography (OCT) examination 14 days post-intravitreal injection. Intraocular pressure was not changed from baseline. Inflammatory or adverse effects were undetectable by slit lamp biomicroscopy. Furthermore, we demonstrate that POE nanoparticles have negligible toxicity assessed at the cellular level evidenced by a lack of glia activation or apoptosis estimation after intravitreal injection. Collectively, POE nanoparticles are a novel and nontoxic as an ocular drug delivery system for the treatment of posterior ocular diseases. 相似文献
12.
Salaam Semaan 《Emerging infectious diseases》2016,22(10):1863-1864
13.
14.
Diabetes mellitus(DM) negatively affects the development and progression of chronic liver diseases(CLD) of various etiologies. Concurrent DM and CLD are also associated with worse clinical outcomes with respect to mortality, the occurrence of hepatic decompensation, and the development of hepatocellular carcinoma(HCC). Unfortunately, early diagnosis and optimal treatment of DM can be challenging, due to the lack of established clinical guidelines as well as the medical complexity of this patient population. We conducted an exploratory review of relevant literature to provide an up-to-date review for internists and hepatologists caring for this patient population. We reviewed the epidemiological and pathophysiological associations between DM and CLD, the impact of insulin resistance on the progression and manifestations of CLD, the pathogenesis of hepatogenic diabetes, as well as the practical challenges in diagnosis and monitoring of DM in this patient population. We also reviewed the latest clinical evidence on various pharmacological antihyperglycemic therapies with an emphasis on liver disease-related clinical outcomes. Finally, we proposed an algorithm for managing DM in patients with CLD and discussed the clinical and research questions that remain to be addressed. 相似文献
15.
16.
17.
18.
Oral Everolimus for Treatment of a Giant Left Ventricular Rhabdomyoma in a Neonate—Rapid Tumor Regression Documented by Real Time 3D Echocardiography 下载免费PDF全文
Robert Wagner M.D. Ph.D. Frank Thomas Riede M.D. Hiroshi Seki M.D. Frauke Hornemann M.D. Steffen Syrbe M.D. Ingo Daehnert M.D. Ph.D. Michael Weidenbach M.D. Ph.D. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(12):1876-1879
The presented case reports on successful treatment with everolimus in a neonate with left ventricular giant rhabdomyoma. The authors used a different dosage regime compared to literature and documented rapid tumor regression by 3D echocardiography. 相似文献
19.
目的:提高静脉留置针使用有效期,保证心血管患者得到及时用药,有效开放静脉抢救通道。方法:建立了心血管患者静脉留置针的临床护理路径(Clinical Nursing Pathway,CNP)。选择我院2018年1-12月期间接诊的静脉留置针心血管患者为研究对象,共100例,随机分组,即对照组(50例,常规护理)与实验组(50例,在常规护理基础上辅以临床护理路径),比较两组护理效果,包括留置时间、不良反应情况、患者满意度等。结果:护理后,两组患者留置时间无明显差异,但实验组不良反应发生率、静脉炎发生率低于对照组,差异有统计学意义(P<0.05);实验组满意度、一次性置管成功率高于对照组,而非计划性拔管率则低于对照组,差异有统计学意义(P<0.05)。结论:心血管患者静脉留置针护理中辅以临床护理路径,可减少不良反应,预防静脉炎,延长置管时间,提高护理满意度,值得优选。 相似文献
20.