胃癌及肠化组织的微卫星不稳定性

目的 :探讨微卫星不稳定性 (MSI)在胃癌及肠化组织中的发生规律及其在胃癌发生过程中的作用。方法 :对 30例胃癌、4 0例肠上皮化生的石蜡标本分别提取病变及相应正常组织的DNA ,应用银染PCR SSCP技术检测 5个微卫星位点的不稳定性。结果 :胃癌组织MSI的发生率为2 3 3% ,胃窦癌MSI的发生率显著高于贲门癌 (P =0 0 4 4 )。肠化组织MSI发生率 2 0 % ,MSI全部出现在中度以上肠化组织中 (P =0 0 13) ,且更多见于女性 (P =0 0 4 4 )。结论 :MSI是胃癌多步骤发生过程中的早期分子事件 ,在胃癌的发生中可能具有重要作用。     

胃癌患者胃液可溶性白细胞介素-2受体初步研究

应用双抗体夹心ELISA法对87例消化道疾病患者胃液可溶性白细胞介素-2受体(sIL-2R)水平进行测定。结果表明,胃癌患者胃液sIL-2R水平明显高于慢性浅表性胃炎及十二指肠溃疡患者(P相似文献   

老年人上消化道出血104例临床分析

分析104例60岁以上的老年人上消化道出血的病因,依次为急性胃粘膜病变,上消化道肿瘤,消化性溃疡及门脉高压。手术治疗效果优于内科保守治疗,而保守治疗又以甲氰咪胍效果较好。     

Blood flow variation and energy metabolism in the gastric mucosa following 7．5％ hypertonic saline resuscitation

Ｂｌｏｏｄｆｌｏｗｖａｒｉａｔｉｏｎａｎｄｅｎｅｒｇｙｍｅｔａｂｏｌｉｓｍｉｎｔｈｅｇａｓｔｒｉｃｍｕｃｏｓａｆｏｌｌｏｗｉｎｇ７．５％ｈｙｐｅｒｔｏｎｉｃｓａｌｉｎｅｒｅｓｕｓｃｉｔａｔｉｏｎＷａｎｇＪｕｎｙｉ（王俊义）；ＷｕＧｕｏｓｈｅｎｇ；（吴...     

胃粘膜上皮“适应性细胞保护”机制防止胃肿瘤发生的作用

投用致癌剂的对照组其胃肿瘤发生率为22.2％。若同时给予40％Z醇液空腹灌胃,则胃肿瘤发生率达55.9％。如在给乙醇液前15分钟,先给予4％的辣椒煎液灌胃,则胃肿瘤发生率只有20.0％,相近于对照组的水平(后2组差别有极显著意义,P<0.01)。这种给损伤剂(乙醇)之前先给予微刺激剂(辣椒)所产生的胃粘膜的保护作用,是通过促使胃粘膜上皮细胞合成内源性前列腺素(PGs)来实现的,是一种“适应性细胞保护”机制。这种保护胃粘膜的作用可降低胃肿瘤的发生率。     

Surgical results of performing R4 gastrectomy for gastric cancer located in the upper third of the stomach

Because gastric cancers located in the upper third of the stomach are difficult to detect at an early stage, the surgical results remain poor. We performed R4 gastrectomy as a radical procedure for 25 patients, involving complete resection of the latero-aortic and interaorticovenous lymph modes above and below the left renal vein, in combination with the ordinary R2 or R3 gastrectomy (the R4 group). These patients were compared with 156 others who underwent R2 gastrectomy alone (the R2 group). There were no significant differences in operation time, blood loss, or the incidence of complications between the two groups; however, when the survival rates of the patients with tumors invading beyond the subserosa were compared, the 5-year survival rate was found to be significantly higher in the R4 group than in the R2 group. Furthermore, in patients with para-aortic nodal involvement, a significant survival advantage was observed in the R4 group, as compared with the R2 group. These results suggest that the R4 gastrectomy is a rational approach for patients with advanced gastric cancer located in the upper third of the stomach.     

鼻腔粘膜吸收庆大霉素功能的研究

用静脉内、肌肉内及鼻腔内三种给药途径给１０只狗按５ｍｇ／ｋｇ用４０ｍｇ／ｍｌ的庆大霉素，并使用双波长色谱扫描法测定０～１８０分钟血清庆大霉素的浓度，比较其生物利用度。发现鼻内给药的生物利用度为静脉注射的８０．５％，肌肉注时为４２％。鼻腔用药后１０～３０分钟血清浓度达到高峰，范围在３．７～６．６μｇ／ｍｌ，半衰期长达３小时左右，表明鼻粘膜对庆大霉素有良好的通透性，可使其迅速吸收入血，并能在血中长时间维持有效浓度。     

Outcome Following Bariatric Surgery in Super versus Morbidly Obese Patients: Does Weight Matter?

Background: Numerous investigators have attempted to identify prognostic indicators for successful outcome following bariatric surgery. The purpose of this study was to determine whether degree of obesity affects outcome in super obese [>225% ideal body weight (IBW)] versus morbidly obese patients (160-225% IBW) undergoing gastric restrictive/bypass procedures. Methods: Since 1984, 157 patients underwent either gastric bypass or vertical banded gastroplasty. Super obese (78) and morbidly obese (79) patients were followed prospectively, documenting outcome and complications. Results: Super obese patients reached maximum weight loss 3 years following bariatric surgery, exhibiting a decrease in body mass index (BMI) from 61 to 39 kg/m² and an average loss of 42% excess body weight (EBW). Morbidly obese patients had a decrease in BMI from 44 to 31 kg/m² and carried 39% EBW at 1 year. After their respective nadirs, each group began to regain the lost weight with the super obese exhibiting a current BMI of 45 kg/m² (61% EBW) versus 34 kg/m² (52% EBW) in the morbidly obese at 72 months cumulative follow-up. Currently, loss of 50% or more of EBW occurred in 53% of super obese patients versus 72% of morbidly obese (P < 0.01). Twenty-six percent of super obese patients returned to within 50% of ideal body weight (IBW) while 71% of morbidly obese were able to reach this goal (P < 0.01). Co-morbidities and complications related to surgery were similar in each group. Conclusions: Super obese patients have a greater absolute weight loss after bariatric surgery than do morbidly obese patients. Using commonly utilized measures of success based on weight, morbidly obese patients tend to have better outcomes following bariatric surgery.     

正常人口腔粘膜不同部位表面感觉的测试

目的 建立正常人口腔粘膜不同部位表面感觉的正常参考值，并测试各年龄组感觉值是否存在差异。方法 利用动静两点辨别觉试验，测试90例健康人口腔粘膜不同部位的表面感觉。结果 舌尖感觉功能最好，其次为舌背、舌腹、颊粘膜、口底和硬腭。健康人的口腔粘膜不同部位的表面感觉随着年龄增长有显著性变化。结论 口腔粘膜不同部位感觉辨别力存在差异，健康人口底、舌腹、舌背、颊和硬腭粘膜感觉功能有增龄性变化。     

胃癌单克隆抗体在裸鼠移植瘤中的免疫定位和显像

本文采用Ｉｏｄｏｇｅｎ法将鼠抗人胃癌单克隆抗体ＲＳＦ９（ＩｇＭ）予以１３１Ｉ标记，研究ＲＳＦ９在荷人胃癌裸鼠中的定位和显像能力。结果表明，ＲＳＦ９在体内能特异性地与肿瘤组织结合，Ｔ／ＮＴ比值随时间延长逐渐升高，９６ｈＴ／ＮＴ比值均大于２．５，瘤／血比值为２．６９，肿瘤定位指数达５．１８，ＳＰＥＣＴ得到清晰的肿瘤图像。ＲＳＦ９具有良好的体内导向定位能力。ＩｇＭ型单抗也可用于肿瘤显像。