Aesthetic considerations in facial reconstructive surgery: The V-Y flap revisited

The subcutaneous pedicled V-Y advancement flap (also known as the kite flap of Dufourmentel) has been described by many authors. Its versatility in reconstructive surgery is well known, both in facial reconstructive surgery as well as surgery of the trunk and extremities. Its advantages in achieving aesthetic reconstruction in specific facial regions have been less well emphasized in the literature. The flap can be designed within natural facial creases and heals inconspicuously because of its widely based subcutaneous or muscle pedicle which incorporates venous and lymphatic drainage over most of its length. The undesirable biscuiting or flap edema frequently observed with other conventional transposition flaps is avoided. We have found the V-Y flap particularly useful in reconstructing the lower eyelid/medial canthus, supra-alar, and nasolabial regions. Our experience with over 40 such flaps is described, and technical considerations in designing and elevating the flap are discussed.     

Effect of phosphatidylserine on free radical susceptibility in human diploid fibroblasts

Summary We studied the effect of phosphatidylserine (PdtSER) on oxygen metabolite toxicity in skin fibroblast cell lines from apparently normal subjects. Fibroblast damage was produced by the generation of oxygen metabolites during the enzymatic oxidation of acetaldehyde by xanthineoxidase (Xo). In order to quantify cell damage, we measured lactate dehydrogenase (LDH) activity in culture medium and cell viability in fibroblast cultures, with and without preincubation for 4 days with PdtSER 13 M, after Xo incubation. We found a significant increase of LDH activity in culture medium of cells without preincubation with PdtSER. No significant increase of LDH activity was observed in the same cell lines after preincubation with PdtSER.     

Respecting the aesthetic units in the surgery of palpebral malignancy

Summary The authors, based on their own experience in this field suggest their own therapeutical view which can be described as follows: a much more frequent use of plastic procedures using sliding flaps from the cheek, associated usually with chondromucosal free grafts from the septum, will give not only much better aesthetic results but also a better guarantee against neoplastic recurrence due to the possibility of being able to carry out a much larger ablation.     

A contribution to a new test method for dandruff-inhibiting and “keratolytic” action of drugs

Summary Free cholesterol in lipids from the scalp and hair is predominantly a constituent of epidermal lipids. Therefore, a reduction in cholesterol content induced by a drug indicates a reduction in cell turnover in the epidermis. As, according to the literature, increased cell turnover in the epidermis results in formation of dandruff, a reduction in the proportion of cholesterol should indicate inhibition of the formation of dandruff. Conversely, an increase in free cholesterol should generally indicate a keratolytic effect. So unequivocal an interpretation has not so far been possible in persons with dandruff, as it was not known whether free cholesterol was increased or decreased. In addition, this interpretation was not possible after use of antimicrobial substances, as in vitro investigations had failed to exclude microbial esterification of cholesterol on the scalp. The present investigation has shown that correlation of free cholesterol level with cell turnover is permissible in patients with dandruff, even if antimicrobial drugs are being tested.     

Effect of short-term administration of lead to pregnant rats.

Lead was administred to adult female rats in drinking water (0;0.1:1 and 10 ppm) for 3 weeks before mating, during pregnancy and during 3 weeks after delivery. On day 21 after delivery the mothers and their newborns were sacrified and various parameters of blood -- lead concentration on (Pb-B), hematocrit (Htc), hemoglobin (Hb), free erythrocyte porphyrins (FEP), delta0aminolevulinate dehydratase (ALAD) -- and tissue -- ALAD, free tissue porphyrins (FTP), lead concentration (Pb-T) -- were determined. In mothers a significant increase in Pb-B and Pb concentration in kidney was found in the 10 ppm group, but this increase in lead concentration was not associated with any statistically significant modification of the biochemical parameters. In newborns, lead concentration in blood and in kidney was also significantly increased in the 10 ppm group and this lead exposure was associated with a decrease of the ALAD activity in blood and an increase of FTP in kidney. On the basis of the biochemical parameters investigated one can therefore conclude that the developing organism is more susceptible to the biological action of lead than the organism of adult animals and that the "no-effect" level of lead administered during pregnancy and in the neonatal period is around 1 ppm.     

带蒂骨膜瓣修补外伤性脑脊液鼻漏

目的：探讨一种有效的外伤性脑脊液鼻漏修补方法。方法：分析本科收治的6例经颅修补的脑脊液鼻漏，采用带蒂骨膜瓣翻转缝合及EC胶严密封闭漏口。结果：无手术死亡，术后脑脊液漏均停止。通过4个月-2年随访，仅有1例术后3个月轻微复发，保守治疗自愈。结论：该方法取材方便，抗感染能力强，一次手术成功率高。尤其适应于额窦后壁、筛窦顶部骨折或缺损所致的脑脊液鼻漏。     

中药提取物在肝微粒体和相关自由基模型中反应性的筛选

背景与目的 :检验“抗氧化剂复合链”假说指导筛选的复合抗氧化剂在大鼠肝微粒体自由基反应模型中的反应性。材料与方法 :微粒体模型和动物模型和微粒体脂质过氧化活化体系包括 :CCl4、Vc/Fe 、CHP、耗氧量等模型以及相关自由基反应模型包括羟胺竞争法发生超氧阴离子自由基和抗坏血酸/铜产生羟自由基等模型 ,筛选和测定了中药的水和乙醇提取物的抗氧化活性 ,以及经过筛选组成的复合抗氧化剂对自由基的综合抑制效应。结果 :当归、人参、枸杞、黄芪、党参的水提取液在微粒体CCl4、VC/Fe 、CHP激发模型及自由基模型中 ,均呈现不同程度的脂质过氧化的抑制作用 ,但是 ,人参水提取液除了对VC/Fe 激发模型的抑制作用较弱外 ,均表现出较强的抗氧化作用 ;枸杞、党参、黄芪水提取液除了对超氧阴离子自由基(O-.)模型和枸杞乙醇提取液对CHP模型呈现较强的过氧化刺激作用外 ,各种乙醇提取液对CCl4、VC/Fe 、CHP和摄氧量激发模型均表现为不同程度的抑制作用。复合抗氧化剂_安体欣对所选模型均呈现较强的自由基生成抑制作用。结论 :中药当归、人参、枸杞、黄芪、党参的水或乙醇单独提取物的抗氧化作用存在局...     

乳腺癌根治术后皮瓣坏死的综合防治策略

皮瓣坏死为乳腺癌术后常见并发症之一，国内外文献报道其发生率均较高。我们根据自己的临床体会、结合文献资料认为导致皮瓣坏死的主要原因为皮瓣组织细胞损伤、皮瓣张力过大、皮下积液及感染、真皮及真皮下血液循环障碍，并针对以上原因采取一系列相应措施，取得了较好疗效，同时对已发生坏死皮瓣的处理进行了简要论述。     

Outcome of children with respiratory symptoms without objective evidence of asthma: a two-year, prospective, follow-up study

This study evaluated the outcome of 33 children with asthma-like symptoms without objective evidence of asthma, and the role of certain factors in predicting the development of clinical asthma in these children. Data on symptom histories, lung functions (flow-volume spirometry, free running test and methacholine inhalation challenge test) and atopic sensitization (skin prick tests and markers of eosinophilic inflammation) were collected twice with an interval of 2 y, and the diagnoses were re-evaluated after the follow-up period. Based on the results, it was concluded that one-third of the children with prolonged or recurrent lower airway symptoms, such as cough or wheeze, either have mild asthma or will develop asthma in the near future. Children who had a significant response [≥ 10% fall in forced expiratory volume in 1 s (FEV1)] in the free running test formed a risk group for active asthma, whereas other baseline characteristics seemed not to predict the outcome.