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81.
Endometriosis and infertility are commonly associated. Thisstudy investigated the role of accelerated lipid peroxidationof spermatozoa by the peritoneal fluid of patients with endometriosisas a cause for this association. It proposes that the increasediron concentration present in the fluid of these patients actsas a catalyst for the process. Peritoneal fluid from 25 patientswith endometriosis and 25 matched controls was obtained at laparoscopy.Spermatozoa were incubated in the fluid from both groups andthe subsequent acrosome reaction rates analysed. The relationshipbetween these results and iron concentration in the fluid wasexamined. A significant decrease in the acrosome reaction ratewas seen in the endometriotic group(P = 0.034). Overall, a decreasein the acrosome reaction rate was associated with an increasediron concentration in the fluid(18 of the 25 pairs). In milddisease, (six of 11 pairs), the relationship was not as markedas that in severe disease (12 of 14 pairs). These results suggestthat the peritoneal fluid in patients with endometriosis hasa detrimental action on the acrosome reaction of spermatozoain vitro. 相似文献
82.
A. A. SANTOS J. XAVIER-NETO A. T. SANTIAGO JR. M. A. N. SOUZA A. S. MARTINS F. ALZAMORA F. H. ROLA 《Acta physiologica (Oxford, England)》1991,143(3):261-269
The effect of acute and sequential volaemic changes on the gastroduodenal flow of saline was assessed in 23 anaesthetized dogs following two different experimental protocols. Hypervolaemia, by i. v. infusion of saline, induced a gradual decrease on gastroduodenal flow which amounted to 76% below control values (P < 0.001) when volaemic expansion attained 5% of body weight. This effect was volume dependent (17% increase on gastroduodenal flow per volume of infused saline equivalent to 0.5% of body weight, P < 0.001), lasted for at least 90 minutes after infusion was completed and was also obtained by expanding previously bled animals. Hypovolaemia due to bleeding was followed by an increase on gastroduodenal flow of about 88% above control values (P < 0.05) when haemorrhage was equal to 3% of body weight. This effect was also volume dependent (23 % increase on gastroduodenal flow per volume of blood shed equivalent to a 0.5% of body weight, P < 0.01) and was reversed after blood volume was restored. These modifications in the resistance of the gastroduodenal segment to the flow of liquid due to acute volaemic changes suggest that the extracellular fluid volume modulates the contractile activity of the gastroduodenal portion of the gut possibly to set a gastroduodenal handling of liquid adequate to cope with volaemic imbalances. 相似文献
83.
84.
Ten patients with subhepatic fluid collections complicating laparoscopic Cholecystectomy were successfully treated by interventional radiological procedures. The series included five abscesses, three hematomas, one biloma, and one serous collection. Abdominal pain or fever developed from 3 to 21 days after the laparoscopic intervention. All patients were asymptomatic 72 h after percutaneous drainage and there were no complications related to the procedure. Subhepatic fluid accumulations are common findings after laparoscopic cholecystectomies and have been considered an unreliable indicator of infection or other postoperative complications. However, the significance of these collections should not be underestimated in symptomatic patients. In such cases we propose diagnostic aspiration and drainage, when necessary, to safely and promptly establish the precise diagnosis and treatment. More serious complications can be avoided by early percutaneous intervention. 相似文献
85.
鼻内窥镜诊治脑脊液漏的临床研究 总被引:1,自引:0,他引:1
目的 探讨鼻内窥镜手术治疗脑脊液鼻漏临床相关因素。方法 对17例(19漏)内窥镜下修补脑脊液鼻漏患者的临床资料作回顾性分析。结果 脑脊液鼻漏17例中,外伤性15例,自发性2例,内窥镜下瘘口修补术一次性治愈15例,成功率88.2%,失败2例,再次修补成功,其中1例颅内高压术后腰穿持续引流减压。结论 内窥镜手术修补脑脊液鼻漏准确、微创;冠位CT薄层扫描对术前瘘口解剖定位有重要意义;影响手术效果的因素与修补材料的固定有关,与修补材料本身无明显关系;术后适当腰穿引流对于临床提示颅内压高、修补区薄弱病例仍需采用。 相似文献
86.
翁工清 《北京中医药大学学报(中医临床版)》2003,10(2):21-23
目的 观察白术桃花汤治疗习惯性便秘的疗效。方法 自拟白术桃花汤 (白术 30g ,桃花 12g ,生地黄 30g ,枳实 10g) ,每日服 1剂 ,7d为 1个疗程。对照组服用果导片作对比观察。结果 白术桃花汤治疗习惯性便秘 117例 ,治愈 10 6例 ,好转 4例 ,总有效率 94 .0 2 %;果导片治疗 6 6例 ,治愈18例 ,好转 30例 ,总有效率 72 .73%。两组总有效率比较 ,经统计学处理P <0 0 1,差异有非常显著性意义。结论 白术桃花汤功能为补气除湿 ,增液行气 ,通调大便 ,治疗习惯性便秘疗效满意。 相似文献
87.
G. N. Kryzhanovskii A. A. Shandra L. S. Godlevskii 《Bulletin of experimental biology and medicine》1988,106(2):1082-1085
Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Department of Pathological Physiology, N. I. Pirogov Odessa Medical Institute. Translated from Byulleten' Éksprimental'noi Biologii i Meditsiny, Vol. 106, No. 8, pp. 146–149, August, 1988. 相似文献
88.
Abstract: The vitamin B12 (VB12) parameter was studied in the serum and cerebrospinal fluid (CSF) of 14 demented patients. Eleven of these patients were in a state of dementia of the degenerative type such as Alzheimer's disease, senile dementia and Pick's disease. The serum VB12 concentration in all the patients was within normal limits, I.e. 500–1,300 pg/ml. There was no significant difference between the CSF-VBl2 levels and the severity of dementia. The serum and CSF-VB12 levels of the demented patients did not show any significant elevation after the oral administration of CH3–Bl2, 2 mg per day. On the other hand, there was a marked elevation of both the serum and CSF-VB12 after an oral medication (2 mg per day) plus intramuscular administrations (500 μg per day). These results confirm that the intramuscular administration of CH3–B12 is an effective way to get a higher value of the serum and CSF-VB12 levels. 相似文献
89.
90.
目的 观察脑脊液中右旋布洛芬浓度随时间变化的情况。方法 新西兰家兔脑部直接注射右旋布洛芬 ,用高效液相色谱法测定其浓度。色谱条件 :KromasilC18(15 0mm× 4 .6mm ,7μm)色谱柱 ,流动相为甲醇∶0 .0 2mmol/L磷酸二氢钾∶乙腈 (6 5∶30∶5 ) ,流速 1.0ml/min ,柱温为室温 ,检测波长 2 2 5nm ,以保泰松为内标。结果 脑脊液右旋布洛芬在 0 .5~ 80 μg/ml范围内线性关系良好 ,r =0 .9994。药物在脑脊液中Tmax为 1.1h ,Cmax为 9.9μg/ml,T1/ 2 为 3.5h ,AUC为 6 1.0 μg·h/ml。结论 HPLC RP法可用于测定脑脊液中右旋布洛芬含量 ,药物在脑脊液中代谢呈一室模型。 相似文献