Topical application of 5-Fluorouracil in premalignant lesions of cornea,conjunctiva and eyelid

Local application of 5-Fluorouracil was practised on 5 patients. In 3 patients with multiple premalignant oculo-cutaneous lesions, two of whom had also premalignant epibulbar lesions, local 5% 5-Fu cream and/or 1% 5-Fu eyedrops were applied. In 2 other patients who had only premalignant lesions on the cornea and conjunctiva, 1% 5-Fu eyedrops were used only. In animal experiments 1% 5-Fu was not found to cause any damage to normal corneal and conjunctival epithelium. The frequency of the applications and the duration of the treatment were dependent on the location and extent of the lesions. Except for easily treatable lesions, caused by the separation of the tumour epithelium, no complications of local 5-Fu treatment were seen. The visual acuity improved in all 4 patients in whom the cornea was affected. In these premalignant conditions the diagnosis and assessment of the therapy were based on exfoliative cytology and biopsies.     

葛根素滴眼液的研制

目的:制备葛根素滴眼液,并评价其特性。方法:以正交设计实验确定的最佳处方和工艺,制备葛根素滴眼液;制订其质量标准并进行毒理实验和稳定性实验。结果:该制剂稳定且无刺激性。结论:该处方设计合理,工艺简单,适合于工业生产。     

Toxic epidermal necrolysis caused by over the counter eyedrops

We present a case of a 15‐year‐old boy who developed toxic epidermal necrolysis (TEN) from sulfacetamide eyedrops. He presented with conjunctival injection and an erythematous rash that rapidly progressed to epidermal necrosis of over 30% of his body. A skin biopsy revealed an acute lichenoid reaction pattern consistent with TEN. After 22 days in hospital, he was left with significant scarring to his eyes, mouth and anogenital areas. An extensive search for an infective aetiology was negative. Previously exposed to bactrim tablets, he used Bleph‐10 eyedrops 3 days before admission to hospital. The patient had a strong family history of sulphur allergy. The onset of TEN after topical administration of medication has been reported rarely in the literature. This case highlights the need for a thorough medication history that includes topical preparations.     

Contact dermatitis caused by allergy to ophthalmic drugs and contact lens solutions

Although a common cause of allergic reactions, topically applied ophthalmic drugs and contact lens solutions are seldom verified as such. This review documents reported allergens and suggests an 'ophthalmic tray', based on the literature search, to simplify patch test verification. The criteria for literature selection were that each patient had a history of allergic reaction to local application of ophthalmic drugs or contact lens solutions, and tested positive to putative allergen patch tests. We established 38 chemicals causing allergic reactions. 5 authors published suggestions for patch test trays.     

贝他根滴眼对幼兔视轴发育及屈光状态的影响

目的 观察Batagan降低眼压对幼兔眼轴发育和屈光状态的影响。方法 1月龄新西兰大白兔30只，1眼滴Batagan每日1次，另眼滴生理盐水每日1次作对照。Schiotz眼压计测量眼压。6个月后用托吡卡胺扩瞳检影。处死动物取眼球测量其前后径。取眼球标本作普通光学显微镜及透射电子显微镜观察。结果 Batagan滴眼能有效降低兔眼眼压4h以上。经持续用药6个月后，其远视度数下降程度小于对照眼，且眼球前后径平衡值小于对照眼。光学显微镜及透射电子显微镜观察角膜、晶状体、视网膜等组织，未发现异常病理改变。结论 发育期眼轴受到眼压影响，降低眼压确能起到抑制眼轴过度发育的作用。     

单纯按摩泪囊与结合滴眼药治疗新生儿泪囊炎

目的比较采用单纯按摩泪囊与按摩结合滴眼药水两种方法治疗新生儿泪囊炎的疗效。方法收集新生儿泪囊炎患者113例,随机分组,一组给予单纯泪囊区按摩治疗,共50例,87眼;另一组给予滴抗生素眼药结合泪囊区按摩治疗,共63例,101眼。统计分析两种治疗方法的疗效差异。结果单纯泪囊区按摩治疗50例,87眼,治愈80眼,占91.95%;滴眼药结合按摩泪囊区63例,101眼,治愈98眼,占97.03%,2组比较无统计学差异（P〉0.05）。结论单纯按摩泪囊与点眼药结合按摩治疗新生儿泪囊炎疗效无明显差异。