双氯灭痛滴眼液的研制

 拟定了双氯灭痛滴眼液的处方及其制备工艺，并制定了质量控制标准。用紫外分光光度法测定双氯灭痛的含量，结果于２７６ｎｍ处有最大吸收。同时对眼刺激性和溶液稳定性进行了试验，表明双氯灭痛滴眼液对眼无刺激，其有效期为２．６年。     

Levocabastine eyedrops in comparison with cromoglycate in the treatment of conjunctivitis in children with birch pollinosis

During the season 65 children, 7–19) yours old, with conjunctivitis due to birch pollinosis were treated with eyedrops, either levocabastine b. i. d. (+ placebo b. i. d.) ( n =32), or cromoglycate q. i. d. ( n = 33). Beclomethasone was given to children with rhinitis. Symptoms of conjunctivitis and sedation as well as pollen counts were assessed daily. Blood was drawn before and at the end of the treatment. When mean weekly scores for symptoms of conjunctivitis or sedation were evaluated there were no significant differences between the treatments. A dynamic statistical method correlating symptoms with pollen counts on the same and previous days was applied showing that the children treated with levocabastine had a quicker reduction of their conjunctivis symptoms after a pollen peak (p < 0.05) but were tired for a longer period (p < 0.01). Other side effects were few and similar in the groups. No significant changes were seen in the blood safety data. The differences between the groups were small, and from a clinical point of view the conclusion is that levocabastine taken twice daily is as effective and as free of side effects as cromoglycate taken 4 times a day.     

润舒滴眼液治疗眼干燥症临床观察

目的　观察润舒滴眼液治疗眼干燥症。方法　 80例患者随机分成两组 ,5 0例为治疗组 ,滴用润舒滴眼液 ,30例为对照组 ,滴用诺氟沙星滴眼液进行对比观察。结果　 5 0例治疗组 1周内显效 47例 ,有效 3例 ,无效 0例 ,对照组分别为 1 0例 ,1 8例 ,2例。治疗组明显优于对照组。结论　润舒滴眼液是治疗眼干燥症的一种理想药物。     

外障眼水长期稳定性的考察

目的建立外障眼水中盐酸小檗碱的含量标准,通过各指标的变化考察其稳定性。方法对6个不同批号的外障眼水一年半内不同时间点进行规定项目考察,用高效液相色谱法检测盐酸小檗碱含量,色谱条件：WaterC18柱（4．6mm×250mm,5gm）;流动相：A为乙腈,B为0．2％三乙胺水溶液,洗脱梯度：0～12min（10％A,90％B）,12～20min（10％～25％A,90％～75％B）,20～35min（25％～35％A,75％-65％B）,35～45min（35％-50％A,65％～50％B）,45—50min（50％～10％A,50％～90％B）,用PHS-3C酸度计测量pH值,用比重瓶测密度,用无菌考察法考察无菌结果。结果外障眼水的盐酸小檗碱含量在70～115μg．ml^-1范围内;pH值、澄明度、相对密度、无菌试验结果各项指标均符合相关标准：pH值为3．5～5．5,相对密度〉1．001g．ml^-1,该制剂为无菌。结论该高效液相色谱法可测定外障眼水中盐酸小檗碱的含量,各检测指标的结果说明该制剂质量稳定、可靠。     

眼刺激试验方法标准化的探讨——一种新眼液的兔眼刺激试验

采用Draize法结合摄相及组织学检查,对治疗用0.4%新眼液进行兔眼刺激试验。以改进的急性眼刺激试验方法对不同浓度的滴眼溶液作眼刺激毒性评价。对各种影响因素进行了研讨。本结果为眼刺激试验方法标准化提供了科学依据。提出筛选不同浓度眼用药物配方和检查错误配方的新方法。     

不同种类前列腺素类滴眼液治疗原发性开角型青光眼的降眼压效果对比

目的比较拉坦前列素、曲伏前列素及贝美前列素滴眼液治疗原发性开角型青光眼患者6周后的降眼压的效果。方法选取2012年10月～2013年10月于承德市中心医院门诊就诊的原发性开角型青光眼患者78例（141只眼）。将其按照给药方法分为三组,每组均为26例,其中Ⅰ组给予拉坦前列素滴眼液（47只眼）;Ⅱ组给予曲伏前列素滴眼液（47只眼）;Ⅲ组给予贝美前列素滴眼液（47只眼）,三组均每日不同时间点滴眼Ⅰ次,疗程为4周．测量比较三组用药前后的24h内、不同时间点的眼压以及用药前后4周内眼压。结果三组治疗前眼压比较,差异无统计学意义（P〉0．05）;三组治疗后24h内各时间点眼压均明显下降,差异有统计学意义（P〈0．05）,但各组间眼内压比较,差异无统计学意义（P〉0．05）;三组用药后4周眼压比较,差异无统计学意义（P〉0．05）。结论采用拉坦前列素、曲伏前列素及贝美前列素滴眼液治疗原发性开角型青光眼患者4周后的降眼压的效果显著．且三种滴眼液治疗效果无明显差异。