消栓通络胶囊加醋外敷治疗注射性静脉炎的研究

[目的]探讨消栓通络胶囊加米醋治疗注射性静脉炎的疗效。[方法]将119例注射性静脉炎病人随机分为对照组和治疗组，对照组采用硫酸镁外敷，治疗组采用消栓通络胶囊加醋外敷，治疗2个疗程后观察疗效。[结果]治疗组总有效率明显优于对照组（P〈0．005）。[结论]消栓通络胶囊加醋外敷治疗注射性静脉炎疗效优于硫酸镁外敷。     

External Application of Chinese Medcine Qu Tong Ling（去痛灵）in Trealing 144 Cases of Cancer Pain

ＥｘｔｅｒｎａｌＡｐｐｌｉｃａｔｉｏｎｏｆＣｈｉｎｅｓｅＭｅｄｃｉｎｅＱｕＴｏｎｇＬｉｎｇ（去痛灵）ｉｎＴｒｅａｌｉｎｇ１４４ＣａｓｅｓｏｆＣａｎｃｅｒＰａｉｎＬＩＰｅｉ－ｗｅｎ（李佩文）；ＨＡＯＹｉｎｇ－ｘｕ（郝迎旭）；ＣＵＩＨｕｉ－ｊｕａｎ（崔惠...     

Neural localization of addicsin in mouse brain

Addicsin is a member of the prenylated Rab acceptor (PRA) 1 domain family and a murine homolog of the rat glutamate-transporter-associated protein 3-18 (GTRAP3-18). This protein is considered to function as a modulator of the neural glutamate transporter excitatory amino acid carrier 1 (EAAC1). However, its molecular functions remain largely unknown. Here, we examined the regional and cellular localization of addicsin in the central nervous system (CNS) by using a newly generated antibody specific for the protein. Distribution analysis by Western blot and immunohistochemistry demonstrated that the protein was widely distributed in various regions of the mature CNS, including the olfactory bulbs, cerebral cortex, amygdala, hippocampus CA1–3 fields, dentate gyrus, and cerebellum. Double immunofluorescence analysis revealed that addicsin was expressed in the somata of principal neurons in the CNS such as the pyramidal cells and gamma-aminobutyric acid (GABA)-ergic interneurons scattered in the hippocampal formation. Furthermore, the protein showed pre-synaptic localization in the stratum lucidum of the CA3 field of the hippocampal formation. Subcellular localization analysis of highly purified synaptic fractions prepared from mouse forebrain supported the cytoplasmic and pre-synaptic distribution of addicsin. These results suggest that addicsin has neural expression and may play crucial roles in the basic physiological functions of the mature CNS.     

ARRIF治疗爆裂型胸腰椎骨折的初步临床报告

目的 应用自行设计的ARRIF对28例胸腰段单个椎体的爆裂型骨折进行切开复位内固定,观察其复位固定效果以及并发症等。方法 从复位结果、手术时间、术中出血量及并发症的发生等方面进行观察,了解ARRIF的临床效果。结果 AR-RIF的手术时间较AF、Dick钉短,术中出血量也较少,未见断钉、断杆及拔钉等并发症。结论 ARRIF能很好地对胸腰段单个椎体的爆裂型骨折进行复位和固定,是一种固定较为确实的经椎弓根内固定器。     

抗滑钢板内固定治疗胫骨平台双髁骨折26例

目的　探讨抗滑钢板内固定治疗胫骨平台双髁骨折的临床效果。　方法　26例胫骨平台双髁骨折,按Schatzker分类为Ⅴ型和Ⅵ型。采用切开复位,胫骨平台外侧使用支持钢板、内侧使用短节段的1 /3管形或重建钢板做抗滑的有限固定。随访至骨折愈合,观察骨折有无再移位,并测定关节活动度和爱荷华(Iowa)膝关节评分。　结果　26例骨折全部愈合,无再移位发生,平均关节活动度为屈曲92°,平均Iowa评分为93分。　结论　联合外侧支持钢板和内侧抗滑钢板内固定治疗胫骨平台双髁骨折是一种很好的选择,但尚需要大规模的病例来验证。     

Open structure rhinoplasty

Open structure rhinoplasty (OSR) uses the open or external approach via a mid-columellar and bilateral marginal incision. In combination with grafting procedures, such as columellar struts, dorsal grafts and tip grafts, rhinoplasty has developed from a merely reductive procedure to a more graduated approach to the nose. Emphasis is now placed on repositioning, augmentation and restructuring the nassal anatomy to create as natural and fuctional a nose as possible. This retrospective study analyses our experience with 130 rhinoplasties over a 3-year-period. The study reveals OSR to be a safe and reliable technique which produces predictable results.     

Idiopathic macrocephaly in the infant: long-term neurological and neuropsychological outcome

RATIONALE: The long-term outcome of idiopathic macrocephaly is presently unknown. METHODS AND RESULTS: In the current study (n=15), MRI conducted at long-term review showed regression of orbito-frontal extradural collections and normal or slightly enlarged ventricular space compared to infant examination. Head circumference had normalised in all but one participant. Neuropsychological assessments of nine participants showed general intellectual ability within the normal range in the majority of participants; however, specific deficits in attention were evident. Clinical interviews conducted with a smaller sub-group revealed anecdotal histories of behavioural difficulties and reading or arithmetic difficulties in half of the total sample. CONCLUSIONS: Prospective review studies such as this indicate that abnormal radiological findings in infancy are not necessarily predictive of neurodevelopmental problems and may reflect a normal variant. However, while overall intellectual ability may be within average limits in this diagnostic sample, considerable individual variations remain in specific areas of neuropsychological function.     

一期同体位前后联合入路手术治疗严重胸腰椎骨折脱位

目的 探讨一期同体位前后联合入路手术治疗严重胸腰椎骨折脱位的治疗效果。方法 1998年10月至2005年9月手术治疗胸腰椎骨折脱位192例，对其中34例严重胸腰椎骨折脱位者采用一期同体位前后联合入路。男25例，女9例；年龄18-56岁，平均34．2岁。损伤节段：T112例，T125例，L111例，L28例，L35例，L42例，L4，51例。Maged分型：A3型12例，B1型2例，B2型2例，C1型12例，C2型4例，C3型2例；ASIA分级：A级7例，B级10例，C级8例，D级6例，E级3例。有神经根损伤症状3例。患者取侧卧位，先行后路椎板减压，椎弓根钉系统临时固定。同体位下再行损伤节段的前路减压支撑植骨，对于骨折脱位者前后协同复位。复位满意及减压彻底后，后路椎弓根钉系统适度加压抱紧前侧支撑植骨，一次完成减压、复位与固定，重建三柱稳定性。结果手术时间180-320min，平均230min。出血量900-2400ml，平均1200ml。术前不完全性神经损伤的24例患者术后神经功能均恢复1级或1级以上。6例出现肋间神经损伤症状，保守治疗后好转。32例随访6-60个月，平均13个月。X线和CT片显示减压和复位效果满意，与术后比较伤椎高度无明显丢失，内固定未见断裂及松动。结论 一期同体位前后联合入路可充分发挥前路与后路手术各自的优势，一次完成减压、复位与固定，为严重胸腰椎骨折脱位提供了一种有效的治疗方法。但手术技术要求较高，应严格掌握手术适应证。     

血管外支架预防静脉桥血管再狭窄的研究进展

冠状动脉旁路移植术(CABG)后，静脉桥的再狭窄是亟需解决的问题。静脉桥管壁过度扩张导致管壁损伤，血管平滑肌细胞增生并向内膜迁移，内膜与中膜增厚，并在此基础上形成粥样斑块，是静脉桥晚期再狭窄的重要原因.静脉桥外放置血管外支架可限制管壁过度扩张，减轻管壁损伤，有效抑制增生的血管新内膜及内膜下泡沫细胞的形成，预防静脉桥的再狭窄，是提高CABG后静脉桥远期通畅率的一种可行的方法。     

Application of an artificial neural network to the control of an active external orthosis of the lower limb

The object of this paper is to present a real-time application of an artificial neural network (ANN). The application for which this network is demonstrated is a motorised orthosis with six degrees-of-freedom for use by a paraplegic; a ‘walking machine’. Theoretical networks and training methods need modification to function correctly with a real application. Several complex phenomena that are very diffucult to model have to be accommodated; the starting threshold of the activators, nonlinearity, noise, and the non-biunivocity between successive system states (position, velocity, actuator controls). The modifications made to the network and the associated training method partially alleviate these difficulties.