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971.
Drs Margaret McCredie Marylon Coates Andrew Grulich 《Cancer causes & control : CCC》1994,5(5):414-421
The incidence of cancer in migrants to New South Wales (NSW) from Cyprus, Egypt, Iran, Iraq, Israel, Lebanon, Syria, and Turkey has been compared with that in the Australian-born population using data from the NSW Central Cancer Registry for 1972–91. Age-standardized incidence rates showed overall cancer incidence to be less common in migrants from each Middle Eastern country than in the Australian-born. There was a clear pattern of generally low rates for cancers of the mouth and pharynx, esophagus, colon and rectum, lung (men only), ovary, prostate and testis, and melanoma. Cancers which tended to be more common in migrants were nasopharynx, stomach (women only), liver (men only), gallbladder (chiefly in women), bladder (men only), and thyroid. Breast cancer did not show a uniform pattern among migrant groups, rates being high in the Egyptian-born but low in Lebanese-born women. The overall low incidence of cancers related to tobacco and alcohol, and to a high fat, low fiber diet, emphasizes the potential role of preventable lifestyle factors in the burden of cancer in Australia. 相似文献
972.
SEARCHFORHERPESSIMPLEXVIRUSTYPE2(HSV-2)ANDHUMANPAPILLOMAVIRUS(HPV)INTHENORMALANDABNORMALCERVICALSAMPLESZhangWei;张伟;JinShunqia... 相似文献
973.
974.
Although breast conserving treatment (BCT) has become the standard therapy for early breast cancer, breast removal is still
recommended for patients with a tumor beneath the nipple or with Paget’s disease. We have employed transposition of a latissimus
dorsi myocutaneous (LD-MC) flap after wide local excision of a tumor with the nipple-areola complex. A new nipple-areola complex
was reconstructed on the LD-MC flap after breast irradiation. Utilizing reconstructive techniques, BCT will likely become
the treatment of choice for more patients with early breast cancer. 相似文献
975.
A 52-year-old Japanese woman developed dermatomyositis. She had undergone a standard radical mastectomy for left breast cancer
21 years earlier. Though no physical sign of recurrent breast cancer appeared clinically, levels of tumor markers were abnormally
elevated. Therefore, tamoxifen and CAF therapy were given. Further, the clinical course of dermatomyositis almost paralleled
the level of serum tumor markers and the clinical course of her recurrent breast cancer. These markers were useful for detecting
the recurrence, following the metastatic disease, and monitoring her response to therapy. 相似文献
976.
Recent studies of the peristaltic pressure wave have suggested the presence of two sequential but overlapping contraction segments in the distal esophageal body. In this report, propagation velocity of esophageal peristalsis was determined in these segments in normal subjects (N=35) and in patients with high-amplitude peristalsis (nutcracker esophagus,N=25) to see if intersegment differences were present in the normal or abnormal setting. Velocity measurements were made from conventional manometric tracings in two 4-cm regions representing the distal smooth-muscle segments. A novel method of velocity measurement was employed that used regression lines established from contraction onset times. In normal subjects, propagation velocity decreased significantly from the proximal to distal segment (4.9±0.5 cm/sec, vs 3.2±0.2 cm/sec,P<0.01). Velocity also decreased across segments in nutcracker-esophagus patients (5.3±0.6 cm/sec, vs 3.6±0.7 cm/sec,P=0.06), but the difference reached statistical significance only when the subset with highest amplitudes (180 mm Hg) was analyzed separately. Greater variance in velocity in the distal smooth-muscle segment of nutcracker-esophagus patients (P<0.01) was, in part, responsible for this statistical observation. We conclude that normal propagation velocity decreases across regions corresponding to the smooth-muscle contraction segments defined by recent studies of peristalsis, supporting the assumption that they represent separate neuromuscular units. The mechanisms responsible for contraction wave abnormalities in the nutcracker esophagus have a minimal effect on propagation velocity, an effect that is restricted to the distal smooth-muscle segment of the esophageal body.Supported in part by a grant from the United States Public Health Service (AM07130). 相似文献
977.
所谓“小粘膜”型胃癌系指病灶直径小于4cm,局限于粘膜层或仅有轻度粘膜下层侵犯的早期胃癌。本文总结经内镜发现并得到手术、病理证实的“小粘膜”型胃癌12例,着重对期诊断问题作一探讨。 相似文献
978.
Formaldehyde, a genotoxic and potent animal carcinogen, is widespread in the working environment as well as in private homes. The risk for cancer morbidity in Denmark during 1970–84 was estimated from standardized proportionate incidence ratios (SPIR) among men whose longest employment had been held since 1964, at least 10 years before diagnosis, in 265 companies in which exposure to formaldehyde was identified. The results do not support the hypothesis that formaldehyde is associated with lung cancer (SPIR=1.0,410 cases). Significantly elevated risks were found for cancers of the colon (SPIR=1.2,166 cases), kidney (SPIR=1.3,60 cases), and sino-nasal cavities (SPIR=2.3,13 cases). For sino-nasal cancer, a relative risk of 3.0 (95 percent confidence interval=1.4–5.7) was found among blue-collar workers with no probable exposure to wood dust, the major confounder. This study provides further evidence that occupational exposure to formaldehyde increases the risk for sino-nasal cancer. 相似文献
979.
Carlo La Vecchia Eva Negri Silvia Franceschi Adriano Decarli Attilio Giacosa Loren Lipworth 《Cancer causes & control : CCC》1995,6(6):545-550
Data from a multicenter case-control study on breast cancer conducted in Italy have been used to analyze the relationship of olive oil and other dietary fats to breast cancer risk. Cases were 2,564 women hospitalized with histologically confirmed, incident breast cancer. Controls were 2,588 women admitted to the same network of hospitals for acute, non-neoplastic, non-hormone related, on-digestive tract disorders. Cases and controls were interviewed between 1991 and 1994 using a validated food-frequency questionnaire. The data were modelled through multiple logistic regression controlling for demographic and reproductive breast-cancer risk factors, energy intake and, mutually, for types of dietary fat. For olive oil, compared with the lowest quintile, the odds ratios (OR) were 1.05, 0.99, 0.93, and 0.87 for increasing quintiles of intake; in a model postulating linear logit increase, the OR per unit (30g) was 0.89 (95 percent confidence interval [CI]=0.81–0.99, P=0.03). Among other oils or fats considered, the OR for the highest level of intake was 0.72 (CI=0.6–0.9) for a group of specific seed oils (including safflower, maize, peanut, and soya) compared with nonusers. The ORs for the highest cf lowest level of intake were 0.80 for mixed or unspecified seed oils, 0.95 for butter, and 0.96 for margarine. The study, based on a large dataset from various Italian regions, shows an inverse relationship of breast cancer risk with intake of olive oil and other vegetable oils, but not with butter or margarine. 相似文献
980.
Yorghos Remvikos Henri Magdelenat Bernard Dutrillaux 《Breast cancer research and treatment》1995,34(1):25-33
The influence of age on the occurrence of phenotypic features of prognostic significance was studied in relation to the DNA index values, measured on DNA histograms from a series of 1019 breast cancer patients. Globally, the distributions of all parameters showed variations with age, the most prominent being the decreases in the percentage of estrogen receptor-negative and high proliferative activity cases with increasing age. When analyzed according to the DNA index classes, all parameters were found to some extent linked with the stage of genetic evolution. However, the associations varied with age, defining two extreme groups. The younger patients (less than 40 years) presented a more complete acquisition of the aggressive phenotype and near-triploid tumors from this group were very frequently steroid hormone receptor-negative, high proliferation, and grade III. By contrast, near-triploid tumors in patients above 65 presented relatively frequently as receptor-positive, low proliferative activity, and even grade I. The correlation of the proliferative status with steroid hormone receptor content led to similar conclusions, high proliferation being more strongly correlated with the absence of estrogen and progesterone receptors in younger patients. Interestingly, the association between high proliferation and negative progesterone receptors was much weaker in patients above 55. Our results suggest that the currently established biological prognostic factors, including DNA profile, steroid hormone receptors, and histopathological grade, show patterns of association which vary with age. Of these, only progesterone receptor could be influenced by menopausal status. These findings have to be taken into consideration for future prognostic factor-related treatment decisions, but also for future methodological improvements of multivariate survival analyses. 相似文献