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Yang Hee Kim Young In Moon Young Hee Kang Jung Sook Kang 《Nutrition Research And Practice》2007,1(4):298-304
This study was conducted to investigate the hypocholesterolemic effect of simvastatin (30 mg/kg BW) and antioxidant effect of coenzyme Q10 (CoQ10, 15 mg/kg BW) or green tea (5%) on erythrocyte Na leak, platelet aggregation and TBARS production in hypercholesterolemic rats treated with statin. Food efficiency ratio (FER, ADG/ADFI) was decreased in statin group and increased in green tea group, and the difference between these two groups was significant (p<0.05). Plasma total cholesterol was somewhat increased in all groups with statin compared with control. Plasma triglyceride was decreased in statin group and increased in groups of CoQ10 and green tea, and the difference between groups of statin and green tea was significant (p<0.05). Liver total cholesterol was not different between the control and statin group, but was significantly decreased in the group with green tea compared with other groups (p<0.05). Liver triglyceride was decreased in groups of statin and green tea compared with the control, and the difference between groups of the control and green tea was significant (p<0.05). Platelet aggregation of both the initial slope and the maximum was not significantly different, but the group with green tea tended to be higher in initial slope and lower in the maximum. Intracellular Na of group with green tea was significantly higher than the control or statin group (p<0.05). Na leak in intact cells was significantly decreased in the statin group compared with the control (p<0.05). Na leak in AAPH treated cells was also significantly reduced in the statin group compared with groups of the control and CoQ10 (p<0.05). TBARS production in platelet rich plasma was significantly decreased in the groups with CoQ10 and green tea compared with the control and statin groups (p<0.05). TBARS of liver was significantly decreased in the group with green tea compared with the statin group (p<0.05). In the present study, even a high dose of statin did not show a cholesterol lowering effect, therefore depletion of CoQ10 following statin treatment in rats is not clear. More clinical studies are needed for therapeutic use of CoQ10 as an antioxidant in prevention of degenerative diseases independent of statin therapy. 相似文献
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P Schuff-Werner E Schütz W C Seyde T Eisenhauer G Janning V W Armstrong D Seidel 《European journal of clinical investigation》1989,19(1):30-37
Heparin-induced Extracorporeal LDL-Precipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen. In 10 adult patients with severe type II hyperlipoproteinemia, a single HELP treatment of 3 1 plasma led to an acute decrease in the average plasma viscosity (PV) from 1.30 to 1.1 mPas. At the same time, an even more marked decrease in the mean erythrocyte aggregation rate from a pathological value of 7.9% to a value of 3.7% (normal range less than 5%) was observed. Long-term studies on five patients demonstrated a lasting improvement in these two haemorheological variables. The acute rheological changes were also accompanied by an improvement in polarographically determined muscle oxygen tension. Mean oxygen tension values measured in both the m.biceps brachii and the m.tibialis anterior in five patients before and after a single HELP treatment increased from 30 +/- 4 to 37 +/- 7 mmHg and from 27 +/- 2 to 31 +/- 3 mmHg respectively. These results may provide an explanation for the rapid improvement in patients' clinical symptoms such as angina pectoris and in stress electrocardiogram which have been observed during HELP therapy. 相似文献
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Objective: To further explore the mechanism of congenital pyrimidine 5'-nucleotidase I deficiency. Methods; The samples were collected from the family members of a patient with P5'N- I deficiency. The enzyme activities were measured by UMP method and the enzyme proteins were quantified by ELISA while the morphology of peripheral blood cells was observed. Results: The enzyme contents reduced as their enzyme activities decreased in the family especially in four members. There was a significant positive correlation(r =0. 955) between the activity and the content of P 5'N- I . The count of the stippling cell was varied in the family. Conclusion.- One of the reasons for congenital P5' N- I deficiency might be the deficiency in the enzyme content. The morphology of peripheral blood erythrocyte may be an assistant diagnotic index. The P5'N- I activities and contents were measured simultaneously may be a effective method in clinic diagnosis. 相似文献
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目的探讨初次献血对红细胞膜Na+-K+-ATP酶活性的影响.方法应用比色法分别检测50例符合献血条件的健康初次献血者献血前后的红细胞膜Na+-K+-ATP酶活性,并对结果进行分析.结果初次献血者献血前后红细胞膜Na+-K+-ATP酶活性分别为3.121±0.441和2.907±0.397 μmol.Pi/107 RBC.h,两者比较无明显差异(P>0.05).结论初次献血对红细胞膜Na+-K+-ATP酶活性无影响,献血不会造成红细胞功能损伤. 相似文献
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晕可消胶囊治疗椎—基底动脉缺血性眩晕疗效观察及其对红细胞膜流动性的影响 总被引:1,自引:1,他引:0
李新毅 《山西中医学院学报》2004,5(4):19-20
目的:较大样本观察晕可消胶囊治疗椎-基底动脉缺血性眩晕疗效及其对红细胞膜流动性的影响。方法:符合入选标准的门诊病例203例随机分为观察组(晕可消组)102例,对照组(维脑路通组)101例,治疗10d后行疗效评定并以荧光偏振法检测红细胞膜流动性的变化。结果:观察组疗效优于对照组,并显著改善了红细胞膜的流动性。结论:晕可消胶囊具有改善红细胞膜流动性作用,用于治疗椎-基底动脉缺血性眩晕疗效肯定,值得推广。 相似文献
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肺结核病人红细胞免疫功能及T淋巴细胞亚群的变化 总被引:1,自引:0,他引:1
①目的探讨红细胞免疫功能及T淋巴细胞亚群变化与肺结核的关系。②方法对44例肺结核病人和44例健康人的红细胞免疫功能、血清循环免疫复合物、T淋巴细胞亚群、NK细胞水平的变化进行了检测,并与对照组比较。③结果肺结核病人红细胞C3b受体花环率(E-C3bRR),CD4,CD4/CD8,NK细胞水平明显降低,CD8水平明显升高,与对照组相比,差异均有极显著意义(t=9.76~22.24,P均<0.01);复治组较初治组变化更明显(t=4.27~15.32,P均<0.01)。E-C3bRR与CD4,CD4/CD8,NK细胞水平呈正相关(r=0.2692~0.5479,P<0.05,0.01),与CD8呈显著负相关(r=-0.374,P<0.01)。④结论红细胞免疫功能、T淋巴细胞亚群及NK细胞的异常与肺结核的发病及病情变化有一定关系。 相似文献
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红细胞不同温度长期冻存后形态和免疫功能的变化及其临床意义 总被引:1,自引:0,他引:1
目的 探讨一种简便、有效的红细胞长期保存的方法。方法 红细胞在-40℃、80℃及-196℃(液氮)不同温度下长期保存18个月后,分别测定冻存前后红细胞平均体积(MCV)、红细胞渗透脆性(RFT)及红细胞免疫功能(RBC-C3bRR、ERPN)。结果 红细胞-40℃长期冻存后,MCV和RFT较冻存前显著提高(P<0.05),RBC-C3bRRt ERPN较冻存前显著降低(P<0.05)。红细胞-80℃、-196℃长期冻存后,MCV、RFT、RBC-C3bRR及ERPN较冻存前无明显改变(P>0.05)。结论 红细胞经-80℃、-196℃长期冻存后,其形态、结构和免疫功能保存良好。-80℃低温冻存是一种简便、有效的红细胞长期保存的方法。 相似文献
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本文测定了第1-7天急性心梗塞患者红细胞磷脂主要组分含量。结果表明,急性心肌梗塞患者红细胞膜的神经鞘磷含量较正常人明显增高;磷酯酰胆硷,磷脂酰丝氨酸、磷脂酰乙醇胺含量却较正常人明显降低。这说明急性心肌梗塞患者存在红细胞磷脂代谢紊乱,这时心肌缺血的重可能产生不良影响。 相似文献