全文获取类型
收费全文 | 13549篇 |
免费 | 1872篇 |
国内免费 | 324篇 |
专业分类
耳鼻咽喉 | 61篇 |
儿科学 | 494篇 |
妇产科学 | 412篇 |
基础医学 | 1245篇 |
口腔科学 | 573篇 |
临床医学 | 1932篇 |
内科学 | 1889篇 |
皮肤病学 | 94篇 |
神经病学 | 1701篇 |
特种医学 | 274篇 |
外国民族医学 | 2篇 |
外科学 | 1056篇 |
综合类 | 1762篇 |
现状与发展 | 5篇 |
预防医学 | 1851篇 |
眼科学 | 160篇 |
药学 | 678篇 |
26篇 | |
中国医学 | 373篇 |
肿瘤学 | 1157篇 |
出版年
2024年 | 56篇 |
2023年 | 339篇 |
2022年 | 568篇 |
2021年 | 764篇 |
2020年 | 835篇 |
2019年 | 712篇 |
2018年 | 674篇 |
2017年 | 670篇 |
2016年 | 675篇 |
2015年 | 615篇 |
2014年 | 1001篇 |
2013年 | 1027篇 |
2012年 | 923篇 |
2011年 | 784篇 |
2010年 | 603篇 |
2009年 | 586篇 |
2008年 | 543篇 |
2007年 | 562篇 |
2006年 | 485篇 |
2005年 | 428篇 |
2004年 | 337篇 |
2003年 | 334篇 |
2002年 | 283篇 |
2001年 | 244篇 |
2000年 | 178篇 |
1999年 | 157篇 |
1998年 | 181篇 |
1997年 | 135篇 |
1996年 | 123篇 |
1995年 | 123篇 |
1994年 | 108篇 |
1993年 | 93篇 |
1992年 | 84篇 |
1991年 | 71篇 |
1990年 | 53篇 |
1989年 | 62篇 |
1988年 | 50篇 |
1987年 | 30篇 |
1986年 | 26篇 |
1985年 | 40篇 |
1984年 | 31篇 |
1983年 | 18篇 |
1982年 | 21篇 |
1981年 | 20篇 |
1980年 | 15篇 |
1979年 | 11篇 |
1977年 | 9篇 |
1976年 | 10篇 |
1969年 | 7篇 |
1968年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
抗神经元抗体对副肿瘤综合征早期诊断的临床意义 总被引:2,自引:0,他引:2
目的 探讨抗神经元抗体抗-Hu、抗-Yo、抗-Ri抗体的检测与副肿瘤综合征早期诊断的关系。方法 采用蛋白免疫印迹分析(Western Blot)法对12例确诊为副肿瘤综合症(PNS)的患者血清及32例非PNS血清进行检测。结果 12例确诊患者血清中检测到一项或多项抗体阳性;PNS患者血清中抗-Hu、抗-Yo、抗-Ri抗体的阳性率高于非PNS对照组,差异有极显著性意义(P<0.01);正常对照组血清抗-Hu,抗-Yo,抗-Ri抗体全部为阴性。结论 抗神经元抗体抗-Hu、抗-Yo、抗-Ri抗体可作为PNS早期诊断及确诊的指标。 相似文献
22.
Three patients who presented with scrotal swelling within a few days of inguinal herniorrhaphy are reported. Ultrasonography scans performed in these patients all demonstrated features suspicious of recurrence of hernia. One patient underwent surgical exploration, which revealed only a scrotal haematoma without evidence of recurrent hernia. The other two patients were managed conservatively because clinically the swellings were regarded to be more compatible with haematoma. Both patients had subsequent resolution of the scrotal swelling with no clinical evidence of recurrence of hernia on follow‐up. It is concluded that sonographic diagnosis of recurrence of hernia shortly after inguinal herniorrhaphy can occasionally be misleading. 相似文献
23.
To evaluate the long-term effects of entacapone on both mean daily 'on' time and health-related quality of life (QoL) in patients with Parkinson's disease (PD) experiencing 'end-of-dose' motor fluctuations and the benefits of an early therapeutic intervention. A prospective, multicenter, observational, 12-month study was performed with an initial 3-month intervention phase, consisting of a phone call to half of the patients from randomly selected investigators to assess if dose adjustment was necessary. Effectiveness was determined by home diaries ('on' time), subscales II and III of the Unified Parkinson's Disease Rating Scale (UPDRS), and the Parkinson's Disease Questionnaire (PDQ-8). After 3 months of treatment, 4.0% of the intervention group patients discontinued the study, versus 18.4% in the control group ( P < 0.01). The improvement in 'on' time was significantly increased since the 3-month visit (21%, P < 0.0001) until the end of the study (23% at 12 months, P < 0.0001). Entacapone also induced significant reductions in the UPDRS scores for subscales II and III and in the PDQ-8 score. 11.2% of patients experienced at least one adverse reaction. This study confirms the effectiveness of entacapone in reducing motor fluctuations by increasing 'on' time, and in improving QoL of PD patients. An early adjustment of entacapone and levodopa doses reduces the number of treatment discontinuations during the first months of treatment. 相似文献
24.
目的 探讨重症急性胰腺炎(SAP)早期治疗体会及外科手术治疗时机和手术方式的选择。方法 对比分析1989—1995年以早期手术为主的36例SAP(A组)与1996—2003年7年中非手术治疗为主的44例SAP(B组)的治愈率和死亡率。结果 B组的死亡率明显低于A组,A组的治愈率低于B组。结论 SAP早期的急性炎症反应期,手术只能加重对机体的打击,加重SAP全身炎症反应,增加手术死亡率。故SAP早期治疗应以非手术疗法为主。当内科治疗无效,手术治疗是唯一的选择,而手术时机的掌握和手术方式的选择更为重要,直接影响手术结果。 相似文献
25.
Disorders in the postnatal nervous, immune, and endocrine regulation systems were revealed in the progeny of rats irradiated
during the preimplantation period of embryogenesis. These disorders persist till adult age. The direction of disorders confirms
the hypothesis about memorization of changed proliferative properties of embryonal cells during the development of the (pro)endocrine
system of a new organism. Memorization results in distortion of postnatal nervous immunoendocrine regulation: hypertrophy
of the endocrine component and coadaptive underdevelopment of the nervous and immune components.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 8, pp. 164–166, August, 1998 相似文献
26.
本文分析1982~1987年间收治的544例异位妊娠,其中270例行腹腔镜检查、274例未作腹腔镜检查。两组资料相比提示:腹腔镜检查组诊断符合率高达97.40%;由于能及早明确诊断,故该组腹腔内出血量比未作腹腔镜检查组少,平均为241m1/372ml(P<0.05),需输血例数明显减少30例(11.11%)/134例(48.90%)(P<0.01),输卵管未破裂者增高222例(82.22%)/194例(70.80%)(P<0.01)。270例无术后并发症发生。上述给年轻不孕患者作非手术治疗或输卵管保守手术以保留生育功能提供良好条件。 相似文献
27.
目的 :介绍食管钡餐连续摄影用于诊断早期食管癌的初步临床应用。方法 :用德国产的数字化胃肠机检查并诊断了 6例早期食管癌病人。与常规食管双重对比造影类似 ,病人立位口服钡剂 ,同时进行连续摄影 ,速度为 2帧 s,持续约 10s。观察不同的时相 ,包括充盈相、黏膜相和双对比相。结果 :在 6例病人中可见食管功能的改变及黏膜皱襞的病变 ,用连续摄影诊断后经内镜及病理检查确诊。 4例病人有轻度扩张受限 ,2例病人有痉挛性收缩 ,1例有钡剂滞留。 6例病人中均可见增粗的或中断的黏膜。 5例病人可见小溃疡。结论 :食管钡餐连续摄影可提供更全面的信息。用此法更可提供食管功能性的改变。 相似文献
28.
Christopher R Pryce Andrea C Dettling Marianne Spengler Christian R Schnell Joram Feldon 《Neuropsychopharmacology》2004,56(2):72-79
BACKGROUND: Early environment is a major determinant of long-term mental health, evidenced by the relationship between early-life neglect or abuse and chronically increased vulnerability to developmental psychopathology, including major depressive disorder (MDD). Animal studies can increase understanding of environmentally mediated causal risk processes. We describe how daily deprivation of biological parenting in primate infants disrupts development of homeostatic and reward systems central to MDD. METHODS: Nine breeding pairs of marmoset monkeys provided control twins (CON) and early-deprived twins (ED); the latter were socially isolated for 30-120 min/day on days 2-28. During the first year of life, basal urinary norepinephrine (NE) titers and cardiophysiologic activity were measured. At the end of year 1 (adolescence), automated neuropsychologic tests were conducted to measure responsiveness to changes in stimulus-reward association (simple/reversed visual discrimination learning) and to reward per se (progressive ratio [PR] reinforcement schedule). RESULTS: The ED monkeys exhibited increased basal urinary NE titers and increased systolic blood pressure relative to CON siblings. The ED monkeys required more sessions to reinstate stimulus-oriented behavior following reversal, suggesting increased vulnerability to perceived loss of environmental control; ED monkeys also performed less PR operant responses, indicating that reward was less of an incentive and that they were mildly anhedonic relative to CON. CONCLUSIONS: In marmoset monkeys, neglect-like manipulation of ED leads to chronic changes in homeostatic systems, similar to those in children and adolescents exposed to early-life adversity and in MDD, and to responses to environmental stimuli similar to those that characterize MDD. 相似文献
29.
肾上腺皮质腺癌的诊断与治疗 总被引:2,自引:0,他引:2
目的 探讨肾上腺皮质腺癌的早期诊断、手术及围手术期处理。方法 回顾分析了1990年至2001年间31例肾上腺皮质腺癌临床资料.并与1978年至1989年同种病例作比较。结果 近10年患者病理分期更趋向早期,更易行根治性切除,5年的存活率明显提高。结论 影像学的发展,使患者易早期诊断;围手术期的充分准备是减少手术并发症及死亡率的关键。 相似文献
30.
Xiao-Mei Mai Per-Olof Gäddlin Lennart Nilsson Ingemar Leijon 《Pediatric allergy and immunology》2005,16(5):380-385
Early catch-up growth and subsequent overweight are suggested to be associated with later cardiovascular diseases and later type II diabetes. However, the impact of early catch-up growth and childhood overweight on the development of asthma has been less studied, particularly in children born with very low birth weight (VLBW). A birth cohort of 74 VLBW children (birth weight < or = 1500 g) was followed from birth and investigated on asthma at 12 yr of age. Early rapid weight gain was in one way defined as an increase of weight > or =1 standard deviation score (SDS) at 6 months of corrected postnatal age. Current overweight was defined by body mass index (BMI) exceeding 21.2 and 21.7 kg/m(2), respectively, for boys and girls at 12 yr of age. Current asthma was diagnosed by a pediatrician, according to asthma ever in combination with a positive response to hypertonic saline bronchial provocation test and/or wheeze at physical examination at 12 yr old. Being overweight at 12 yr of age was associated with an increased risk for current asthma in the VLBW children [crude odds ratio (OR): 5.5, 95% confidence interval (CI): 1.3-22.2]. After adjustment for early weight gain and neonatal risk, the OR of overweight increased nearly three times (adjusted OR: 15.3, 95% CI: 2.5-90.6). Early rapid weight gain seemed to be inversely associated with current asthma (adjusted OR: 0.49 for an increase of weight equal to 1 SDS, 95% CI: 0.23-1.02, p = 0.06). In addition, early rapid weight gain was inversely associated with the magnitude of bronchial responsiveness at 12 yr (coefficient -1.15, p < 0.01). There was a strong and positive association between overweight and asthma at 12 yr of age in the VLBW children. This strong association had been reduced by early rapid weight gain, possibly via the reduction of bronchial responsiveness. 相似文献