三种不同波长激光猴眼小梁成形术的组织学观察和比较

目的 研究激光小梁成形术机理,进一步推广其在临床的应用。方法 对氢激光、倍频Ｎｄ：ＹＡＧ激光、半导体激光小梁成形术后１０ｄ,１ｍｏ、６ｍｏ的猴眼房角进行组织学观察和比较。结果 激光小梁成形术后光凝区的小梁被破坏,前房侧小梁表现出现一从角膜内皮细胞延伸过来的细胞层。三种波长激光都能有效地进行小梁成形术,其中半导体激光所造成的损伤较其他２种大。结论 房水流出阻力下降,房水流出量的增加可能与光凝区前房侧     

2,7(3,6)-Diaryl(arylamino)-substituted Carbazoles as Components of OLEDs: A Review of the Last Decade

Organic light emitting diode (OLED) is a new, promising technology in the field of lighting and display applications due to the advantages offered by its organic electroactive derivatives over inorganic materials. OLEDs have prompted a great deal of investigations within academia as well as in industry because of their potential applications. The electroactive layers of OLEDs can be fabricated from low molecular weight derivatives by vapor deposition or from polymers by spin coating from their solution. Among the low-molar-mass compounds under investigation in this field, carbazole-based materials have been studied at length for their useful chemical and electronic characteristics. The carbazole is an electron-rich heterocyclic compound, whose structure can be easily modified by rather simple reactions in order to obtain 2,7(3,6)-diaryl(arylamino)-substituted carbazoles. The substituted derivatives are widely used for the formation of OLEDs due to their good charge carrier injection and transfer characteristics, electroluminescence, thermally activated delayed fluorescence, improved thermal and morphological stability as well as their thin film forming characteristics. On the other hand, relatively high triplet energies of some substituted carbazole-based compounds make them useful components as host materials even for wide bandgap triplet emitters. The present review focuses on 2,7(3,6)-diaryl(arylamino)-substituted carbazoles, which were described in the last decade and were applied as charge-transporting layers, fluorescent and phosphorescent emitters as well as host materials for OLED devices.     

氢化可的松及其注射液有关物质检查

目的:对氢化可的松原料及其注射液中含有的有关物质进行测定。方法:采用高效液相色谱法进行分析,同时采用二极管阵列检测器进行杂质波谱扫描,液质联用法辅助确定主要杂质的结构。结果:氢化可的松和杂质峰分离良好,试验样品主要杂质确证为6,17,21β-三羟基孕甾-4-烯-3,20-二酮、表氢化可的松、17,21-二羟基孕甾-4-烯-3,20-二酮、可的松及泼尼松龙。结论:本法准确、灵敏,杂质检出性强,适用于氢化可的松及其注射液有关物质的测定。     

Src/NF-κB-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract

Ethnopharmacological relevance

Raw and processed Polygoni Multiflori Radix (PMR) are used in the prevention and treatment of non-alcoholic fatty liver disease (NAFLD), hyperlipidemia or related diseases. However, few researches compared the activities of raw and processed PMR on lipid metabolism regulation. Moreover, the active substances of Polygonum multiflorum are still not clearly elucidated.

Materials and methods

In this research, a sensitive, accurate and rapid in vitro model, steatosis hepatic L02 cell, was applied to compare the relative activities of raw and processed PMR on lipid metabolism regulation. Furthermore, the lipid regulation activities of emodin, physcion and 2,3,5,4′-tetrahydroxy-stilbene-2-O-β-d-glucoside (TSG) were evaluated. The steatosis L02 cells were obtained after cultured with 1% fat emulsion-10% fetal bovine serum (FBS)-RPMI 1640 medium for 48 h. Contents of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in L02 cells are evaluated after exposure.

Results

The intracellular TG contents were increased from 16.50 ± 1.29 mmol/L to 34.40 ± 1.36 mmol/L in steatosis L02 cells, while the intracellular contents of TC were increased from 5.07 ± 1.80 mmol/L to 11.79 ± 0.54 mmol/L. Water extract of raw PMR showed much remarkable TG-regulation and TC-regulation effects than its processed products. Emodin displayed the best TG regulation activity while TSG showed the best TC regulation activity. At the same time, the exposure of emodin and physcion could reduce the LDL-C contents in steatosis L02 cells.

Conclusions

On account of these in vitro results, raw PMR might have more satisfactory effects in clinic treatment of NAFLD or hyperlipidemia characterized by the elevation of cholesterol than processed PMR.     

王琦教授应用枳术丸治疗功能型便秘的经验探讨

对于名方的应用,主要学习其制方思想,临证时既能执守,又能圆通,明其理而活其法。徐大椿在《兰台轨范·序》中言:"一病必有主方,一病必有主药。"王琦教授临床常以主病主方思想治疗疾病,针对性强,疗效显著。文章以枳术丸治疗功能性便秘为例,试论王琦教授主病主方学术思想和临床经验。     

《伤寒论》教学灵魂在“活”字——赴新加坡教学体会

<正>在快乐中学习,从学习中找到快乐,是学习的最佳境界。本人于2011年4月赴新加坡中医学院讲授《伤寒论》,一月的教学,时时处于快乐之中,书本"活",老师"活",同学"活",整一个"活生生"、"活泼泼"。现将心得与同道分享。1鲜活的案例此次赴新加坡,我们带去了广州中医药大学伤寒论病区拍摄的临床教学查房视频,包括查房与讨论两部分。病案介绍电子版打印后交同学,人手一册,让其预习。一般安排在每次教学近尾时,进行视频案例讨论。首先针对病案提出辨治思路;观看查房视频后进行讨论;随后观看讨论