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111.
吸入糖皮质激素治疗感染后咳嗽 总被引:2,自引:0,他引:2
目的研究吸入糖皮质激素对感染后咳嗽的治疗效果及对气道炎症细胞的影响。方法采取前瞻性随机对照研究,将60例年龄在18~65岁的感染后咳嗽患者(咳嗽持续3周以上)随机分为观察组和对照组接受1周的治疗。观察组每天吸入布地奈德800μg,同时口服马来酸氯苯那敏和右美沙芬;对照组口服马来酸氯苯那敏和右美沙芬治疗。在治疗前、治疗后1周分别记录患者咳嗽特异性生活质量评分(CQLQ评分表),查诱导痰炎症细胞分类。结果治疗1周后,观察组CQLQ评分(35.38±10.65)明显降低,比对照组(46.57±7.49)降低明显(P<0.05)。观察组诱导痰中性粒细胞百分数在治疗1周后为(42.35±7.82)%,比对照组(63.24±10.24)%低(P<0.05)。结论吸入糖皮质激素对感染后咳嗽有明显疗效,可显著改善患者生活质量;气道中性粒细胞减少可能是激素的作用机制之一。 相似文献
112.
Summary Eleven arthritic knee joints in seven patients with rheumatoid arthritis were studied before and after intraarticular injection of a corticosteroid preparation. Extensor muscle torque and quantitative electromyography increased on days 7 and 14 after treatment, indicating that muscle function had been inhibited by synovitis. Clinical signs of synovitis, such as pain, range of motion and knee circumference, also improved. Synovial fluid withdrawal alone improved extensor muscle torque. Joints with instability and/or radiological cartilage involvement also improved. 相似文献
113.
A 7-week-old male infant tested positive for autoimmune hemolytic anemia. Serological studies revealed a positive Coombs test and a strong antibody with relative anti-E specificity. Despite corticosteroid therapy, he frequently suffered severe hemolytic crises. During the course of the disease he had pneumonia, subcutaneous abscess, and sepsis, which were thought to be caused by his immunosuppressive state. His clinical course was chronic and refractory. Recently, high-dose intravenous IgG therapy for the treatment of chronic AIHA has been reported, but it has not been successful in the management of adult AIHA. We attempted this therapy in our patient, and successful management was obtained. 相似文献
114.
J. T. W. van Dalen M.D. Ph.D. M. D. Sherman 《Documenta ophthalmologica. Advances in ophthalmology》1989,72(3-4):273-277
We describe twenty-one patients on sustained corticosteroid therapy who presented with exophthalmos. Each patient received a complete ophthalmologic examination and further tests were conducted to rule out other causes of exophthalmos. Our data suggest that corticosteroid-induced exophthalmos is an entity more common than has been previously recognized. 相似文献
115.
Takuhiro Kohsaki Isao Nishimori Keisuke Taniuchi Eiki Miyaji Nobuto Okamoto Masanori Morita Saburo Onishi Shino Kohsaki Yoshimasa Fujiwara Shoji Yoshida 《Digestive endoscopy》2000,12(4):354-357
We present a case of a 67‐year‐old female with polyarteritis nodosa, complicated by pneumatosis cystoides intestinalis. The definite diagnosis of polyarteritis nodosa was obtained by histological findings on a biopsy specimen from her sural nerve. Following steroid pulse therapy, she developed gastrointestinal symptoms such as nausea, abdominal fullness and watery diarrhea. Abdominal X‐ray and computed tomography showed an abundance of gas contrast within the large intestinal wall. Colonoscopy revealed submucosal tumor‐like multiple elevated lesions from the sigmoid to transverse colon. These findings indicated pneumatosis cystoides intestinalis and the patient was accordingly treated with a high concentration of oxygen via a nasal catheter. One week later, her symptoms and the gas in the bowel wall completely disappeared. Pneumatosis cystoides intestinalis may be one of the complications of steroid pulse therapy. 相似文献
116.
Asthma: Versatile Treatment for a Variable Disease 总被引:1,自引:0,他引:1
Kevin R. Murphy 《The Journal of asthma》2005,42(3):149-157
Objective. This review describes factors contributing to the variable nature of asthma and the versatile treatment strategies required for the clinical management of the disease. Data Sources. A comprehensive review of the literature using MEDLINE was conducted. Study Selection. Included articles were selected for their relevance to variability or severity of asthma. Bibliographies of selected articles served as additional sources of considered publications. Results. Asthma severity can vary substantially among patients and within individual patients because of physiologic, environmental, or behavioral factors. Inhaled corticosteroids are an effective and versatile treatment option for special populations with asthma and for patients with varying degrees of asthma severity. Inhaled corticosteroids are now the preferred treatment for all three severity levels of persistent asthma, especially in young children and pregnant women. Treatment regimens may be adjusted up or adjusted down when appropriate to maintain optimal symptom control and limit potential adverse systemic effects. Conclusions. The clinical management of asthma is challenging given the day-to-day variability of the disease. Variability in pulmonary function and asthma symptoms may be minimized through increased awareness of the factors contributing to asthma variability as well as the effective use of inhaled corticosteroid therapy. Flexible treatment strategies that consider the different severities of asthma and account for variability within individual patients may be particularly useful in improving adherence and patient outcomes. 相似文献
117.
David E. Weissman Denise Dufer Victor Vogel Martin D. Abeloff 《Journal of neuro-oncology》1987,5(2):125-128
Summary Hospital charts from 59 patients with intracranial malignancy or epidural spinal cord compression were reviewed to establish
the frequency of clinically important corticosteroid toxicities and to determine treatment or patient characteristics which
were predictive for toxicity. Thirty patients (51%) developed at least one steroid toxicity and eleven (19%) required hospital
admission for diagnosis and/or management of steroid-related complications. In this retrospective analysis the duration of
steroid therapy and the total administered dose predicted for toxicity. Patients with toxicity also had a significant fall
in the serum albumin level. Important corticosteroid toxicity occurs frequently in neuro-oncology patients. Further research
should be directed at developing non-toxic alternatives to corticosteroids. 相似文献
118.
119.
Tolosa-Hunt syndrome preceded by facial palsy 总被引:11,自引:0,他引:11
The Tolosa-Hunt syndrome consists of a painful ophthalmoplegia related to a granulomatous inflammatory process in the cavernous sinus, which may be documented by cerebral magnetic resonance imaging with gadolinium enhancement. Two cases of Tolosa-Hunt syndrome preceded by facial palsy observed in 1998 at the Department of Neurosurgery of the Second University of Naples are presented here. Both patients developed Tolosa-Hunt syndrome following an ipsilateral facial palsy that resolved in about 15 days with medical treatment. Cerebral magnetic resonance imaging with gadolinium enhancement showed, in both cases, inflammatory tissue in the cavernous sinus. The patients underwent corticosteroid therapy (prednisolone, 80 mg per day, intravenously) with pain regression. In the first case, the patient experienced recurrence of the syndrome that was definitively resolved with further corticosteroid treatment. The rare reports of facial palsy in patients with Tolosa-Hunt syndrome suggest the inclusion of this disease in the so-called multiple cranial nerve palsy syndrome. It is probable that Tolosa-Hunt syndrome has an inflammatory pathogenesis. 相似文献
120.
Headache Associated With Aseptic Meningeal Reaction as Clinical Onset of Fabry's Disease 总被引:1,自引:0,他引:1
Dr. E. Uyama MD Dr. N. Ueno MD Dr. M. Uchino MD Dr. T. Narahara MD Dr. M. Owada MD Dr. T. Taketomi MD Dr. M. Ando MD 《Headache》1995,35(8):498-501
This report concerns an 18-year-old boy who is hemizygote for Fabry's disease. Varying degrees of nonpulsating headache crises, lasting from a few hours to several days, began when he was 16 years of age. Painful crises in the extremities, characteristic of Fabry's disease, were not present. Although only occasional, he had several episodes of throbbing headache with vomiting without aura. The meningeal signs were equivocal, although the patient had noninfectious pleocytosis, intracranial hypertension, delayed radioisotope clearance on cisternography, and multiple old cerebral infarcts. Nonsteroidal anti-inflammatory drugs, antidepressants, carbamazepine, and glycerol were of no benefit for his headache. Although its mode of action remains obscure, prednisolone was effective for treating the headache and the aseptic meningeal reaction. 相似文献