Acne treatment with a 1,450 nm wavelength laser and cryogen spray cooling

BACKGROUND AND OBJECTIVES: A laser with a wavelength in the mid-IR range targeting the depth in skin where sebaceous glands are located in combination with cryogen spray cooling was evaluated for treatment of acne. In this non-ablative treatment, the laser energy heats the dermal volume encompassing sebaceous glands whereas the cold cryogen spray preserves the epidermis from thermal damage. STUDY DESIGN/MATERIALS AND METHODS: Monte Carlo simulations and heat transfer calculations were performed to optimize the heating and cooling parameters. A variety of heating and cooling parameters were tested in an in vivo rabbit ear study to evaluate the histological effect of the device on sebaceous glands and skin. Similar experiments were performed on ex vivo human skin. A clinical study for the treatment of acne on backs of human males was also conducted. RESULTS: Monte Carlo simulations and heat transfer calculations resulted in a thermal damage profile that showed epidermal preservation and peak damage in the upper dermis where sebaceous glands are located. Ex vivo human skin histology confirmed the damage profile qualitatively. In vivo rabbit ear histology studies indicated short-term thermal alteration of sebaceous glands with epidermal preservation. In the human clinical study on the back, a statistically significant reduction in lesion count on the treated side compared to the control side was seen (p < 0.001). Side effects were transient and few. CONCLUSIONS: The studies reported here demonstrate the feasibility of treating acne using a photothermal approach with a mid-IR laser and cryogen cooling.     

网络版的医疗设备资产管理模块设计与应用

本文应用微软的IIS、DREAMVEAVERMX建立设备管理信息系统，并使用ASP、JAVASCRIPT语盲开发资产管理模块。结果表明，该模块的使用可以提高资产密集单位的管理效率。     

深圳市公共场所中央空调冷却塔军团菌污染现况调查

目的 了解深圳市中央空调冷却塔军团菌污染现况及水环境的pH值、温度等因素对军团菌的影响。方法采集空调冷却塔水共132份进行军团菌病原学检测。结果所调查的公共场所中有33家空调冷却塔受到军团菌污染，污染率57．90％(33／57)；有58个空调冷却塔检出军团菌，检出率43．94％(58／132)。结论深圳市中央空调冷却塔存在军团菌污染，已对暴露人群构成威胁，应采取有效防范措施。     

医用吸氧计时器的研制

医用吸氧计时器 ,是通过气体流动传感器 ,采集病人吸氧动作 ,经比较放大电路、 89C5 1单片机、时钟模块、编码复位和显示电路组成计时系统。     

DPK液晶显示器在医学仪器上的应用

DPK液晶模块是D-Peak公司出品的液晶显示模块,该液晶具有大屏幕、268色彩色显示、高亮度等优点,十分适合于各种工业、医学、银行等行业的显示场合。本文结合笔者开发的“新生儿脑血氧监护仪”介绍了该液晶模块在医学仪器上的应用,并且给出了与MCS-51单片机的硬件连接电路图和基于KeilC51编程语言的驱动程序实例。     

寒温并用法治疗慢性萎缩性胃炎42例

目的观察寒温并用法治疗慢性萎缩性胃炎的疗效。方法以张仲景半夏泻心汤为基本方,治疗慢性萎缩性胃炎42例（治疗组）,并与西药常规治疗的32例作对照。结果治疗组临床症状疗效总有效率及病理疗效总有效率分别为92.86%、71.43%,对照组分别为78.12%、53.13%,2组比较有显著性差异（P〈0.05）;治疗组胃痛、嗳气、食欲不振、神疲乏力等症状改善优于对照组（P〈0.05）。结论寒温并用法治疗慢性萎缩性胃炎疗效确切。     

护理技能强化训练模块实践研究

针对护理专业学生人数迅速增加，护理技能操作教学增加了难度，设定护理技能强化训练模块，经过两届护理专业申专层次573名学生的实践，取得了较为满意的效果。体现了职业教育模块教学的针对性和灵活性，提高了护理专业学生护理技能操作水平，形成了较为完整的强化训练模块管理制度。     

Portal circulation and the function of hepatocytes during ex vivo perfusion of the rat liver preserved for six hours after core cooling

Portal circulation and the function of hepatocytes during isolated organ perfusion were compared between the rat liver perfused immediately after extirpation and the liver perfused after core cooling and six hours of preservation. Nine rat livers were extirpated after core cooling, preserved for six hours in University of Winsconsin (UW) solution at 4°C and then were connected to a perfusion chamber (hypothermic preservation group: 6-hr HP group). Six rat livers were immediately connected to the perfusion chamber after extirpation (control group). During 60 minutes of isolated liver perfusion, both portal circulation and the function of hepatocytes were determined every 10 minutes. Portal vein resistance increased and portal blood flow decreased during the first 20 minutes of perfusion and then stabilized in both groups. Portal vein resistance was significantly higher and portal blood flow was significantly lower for the first 10 minutes of perfusion in the 6-hr HP group, compared to the control group. The function of hepatocytes, determined by the rate of elimination of ammonia, oxygen consumption, and glucose availability were depressed in the 6-hr HP group, compared to the control groups during isolated liver perfusion. However, there was no statistically significant difference of portal perfusion and the function of hepatocytes between the two groups at the end of perfusion. The results of the present study indicate that the rat liver can be preserved in a satisfactory condition for six hours by the use of hypothermic preservation, coupled with core cooling.     

Radiofrequency ablation in the liver close to the bile ducts: can intraductal cooling offer protection?

Background One complication of radiofrequency ablation (RFA) of the liver is biliary duct damage. Intraductal cooling (IDC) has been proposed as a means of protection.Methods In the first experiment, designed to evaluate the influence of IDC on the RFA procedure per se and on lesion formation, lesions were created in vivo in pig liver with and without IDC. The RFA needle was placed with a 1.5-cm safety margin from the bile ducts. In the second experiment, designed to evaluate the potential protective effects of IDC, lesions were created close to a bile duct with and without IDC.Results With the safety margin, the RFA parameters and lesion size were not negatively affected by IDC. Microscopic examination revealed that IDC had a protective effect in most of the lesions created close to a bile duct.Conclusions The IDC procedure was feasible and had no negative effect on the RFA procedure or the lesions. However, the protective effect of IDC was not statistically significant (p = 0.12).