老年男性高血压与前列腺增生的相关性研究

目的探讨高血压与良性前列腺增生发生、发展的相关性。方法选择男性前列腺增生患者223例,根据欧洲高血压学会/欧洲心脏学会高血压治疗指南将患者分为血压正常组(正常组)66例和原发性高血压组(高血压组)157例。其中高血压组病程≤15年患者96例,>15年患者61例;杓型血压患者58例和非杓型血压患者99例。检测血压、血脂和前列腺特异性抗原(PSA)等;超声测量并计算前列腺体积;行24h动态血压监测。结果与正常组比较,高血压组全天平均收缩压、前列腺体积、前列腺体积年增长率明显升高(P<0.05)。前列腺体积与高血压病程和PSA呈正相关(r=0.18、r=0.56,P<0.05),前列腺体积年增长率与年龄、PSA及体质量指数呈正相关(r=-0.20、r=0.49、r=0.20,P<0.05)。高血压病程>15年及非杓型血压患者前列腺体积及前列腺体积年增长率明显高于高血压病程≤15年及杓型血压患者(P<0.05)。结论前列腺增生发生、发展与高血压密切相关。高血压病程及其血压昼夜节律对良性前列腺增生均有影响。     

Impact of the COVID-19 Pandemic on Health-Related Concerns,Quality of Life and Psychological Adjustment in Young Adults with Congenital Heart Disease

Background: The risk for a severe disease course in case of infection with SARS-CoV-2 in young adults with congenital heart disease is largely unknown, potentially leading to uncertainty and anxiety among affected patients. This study aims to investigate health-related concerns, health-related quality of life and psychological adjustment in patients with congenital heart disease compared to healthy peers during the COVID-19 pandemic. Methods: One-hundred patients with congenital heart disease and 50 controls (M = 29.7, SD = 3.8 years) were recruited. They completed an online survey including the assessment of health-related concerns regarding COVID-19, the 12-item Short Form Health Survey and the Brief Symptom Inventory. Results: Patients considered COVID-19 to be a more serious issue (Generalized odds ratio [GenOR] = 1.67, p = 0.04), were more concerned about becoming infected (GenOR = 2.93, p < 0.001) and expressed more fear about leaving their homes (GenOR = 1.81, p = 0.004) while general anxiety symptoms were not different between groups (p = 0.23). Patients relied more on family and friends for support (30% vs. 2% in controls, p < 0.001) and reported better compliance with protective measures (p = 0.03). Mental health-related quality of life and psychological adjustment were not different between groups (p = 0.17 and p = 0.68, respectively). Physical health-related quality of life was lower in patients compared to controls (p = 0.03). Conclusions: Young adults with congenital heart disease in Switzerland are more concerned about their health during the COVID-19 pandemic compared to healthy peers. These concerns, however, do not translate into generally impaired mental wellbeing. The impact of the easing of lockdown measures on long-term anxiety levels and quality of life requires further study     

Stenting an aortopulmonary conduit with peripheral cardiopulmonary bypass support

Although surgically created aortopulmonary (AP) shunts are uncommon in the adult congenital heart disease population, they are often used in patients with pulmonary atresia. For these patients, the shunt is a vital supply of pulmonary blood flow and thus obstruction of the shunt may lead to pulmonary hypoperfusion and hypoxia thereby increasing morbidity and mortality. This report describes a safe and effective method of stenting the conduit with the hemodynamic support of peripheral cardiopulmonary bypass (PCB). Prior to the procedure, a multimodality assessment of a stenosis in a kinked AP conduit using computed tomography, angiography, intravascular ultrasound (IVUS), and pressure wire assessment (PWA) was utilized. While PCB, IVUS, and PWA have all been used to great effect in various clinical scenarios, the combined use of these techniques has not been previously been described in the setting of intervention in adult congenital heart disease. © 2013 Wiley Periodicals, Inc.