1993～2004年江门市性病流行病学分析

目的了解江门市性病流行趋势和流行特点,为制定防治对策提供科学依据。方法对1993～2004年江门市的性病疫情报告资料进行流行病学分析。结果1993～2004年江门市性病发病呈快速增长趋势,由1993年的1403例(发病率63.52/10万)上升到2004年的9101例(发病率225.91/10万),年均增长18.53%,增长幅度最大的是梅毒,年均增长55.06%,其次依次是生殖器疱疹(GH)、非淋菌性尿道炎(NGU)、尖锐湿疣(CA)、淋病,年均增长分别是50.73%、36.14%、15.99%、2.93%;女性性病报告病例数从1993年的500例增长到2004年5010例,年均增长23.3%,高于同期男性的14.7%;20～29岁年龄组发病率最高,其次依次为30～39、40～49、≥50岁组,而<15岁组最低;非婚性接触是性病传播的一个最主要感染源。结论江门市性病流行形势日益严峻,应引起足够重视。     

谈日语二外教学中实际运用能力的培养

学习外语的第一目的是与人交流，二外亦是如此。特别是当前中国经济快速发展，对日语人才的需求越来越大的环境下，如何提高日语二外学习者的语言实际运用能力成为一个重要课题。结合笔者的实践，本文着重从听、说以及跨文化交际三方面探讨了日语实际运用能力的培养。     

不同分化胃癌细胞系中间隙连接蛋白的表达

目的探讨间隙连接蛋白（Cx）Cx26、Cx32、Cx43、Cx45在转化的人胃细胞系（GES-1）、胃高分化腺癌细胞系（N87）和胃低分化腺癌细胞系（BGC-823）中的表达及其与胃癌发生、发展的关系。方法采用间接免疫荧光方法检测Cx26、Cx32、Cx43、Cx45在不同分化程度胃癌细胞株中的表达，并分析该蛋白表达与胃癌发生、发展的关系。结果在不同分化胃癌细胞株中。Cx26、Cx32、Cx43、Cx45表达呈现1个由高水平到低水平表达直至无表达的梯度分布，既Cx26、cx32、Cx43、Cx45在GES-1中高水平表达，在N87表达减少，在BGC-823中无表达，并且表达部位有差异。结论Cx26、Cx32、Cx43、Cx45的表达与胃癌细胞的分化关系密切，在胃癌的发生、发展中有一定作用。     

医学影像存储与传输系统存储模式的探讨

目的 探讨医学影像存储与传输系统中的存储介质、结构，提高图像存储容量及调用速度。方法PACS采用三级（在线、近线、离线）存储结构；利用硬盘、多服务器磁盘阵列、磁带库等作为存储介质，支持影像数据的短期存储管理和长期存储管理；采用冗余存储技术和镜像存储方式；提供定时自动备份和数字迁移功能。结果成功地实现了医学图像在网络中的存储、备份及调用。结论PACS中的三级存储模式大大提高了图像的存储容量及调用速度，提高了工作效率。     

用于存储传输和分析的12导联同步心电图标准化系统的设计

不同厂商生产的心电图机输出的数据格式不同,这给数据的传输、交换和分析造成了很大的障碍。作者旨在建立基于web的用于心电图数据存储、传输和分析的各医院门诊之间统一的心电图标准化系统。把心电图机输出的文件(标准心电图协议格式SCP)中记录头文件采集到设计的标准数据库,实现了对不同品牌心电图机心电图存储和分析功能。     

双边互动优化有机化学教学过程

通过调动学生积极性、利用多媒体教学、让学生参与教学活动、改进考试方法、给学生创造一个能发挥学习能动性的环境,从教学的每一个环节激发学生求知欲、培养学生学习兴趣。教学是师生的双边活动,是教师教和学生学的互动过程,这个过程既是传授知识的过程,也是发展和培养学生能力的过程。     

由疫区医院SARS防治经验浅探突发性传染病防治模式

SARS暴发流行期间，疫区内医院面对复杂的社会环境、人群分布及致病原因不明、传染性强、传播途径不详、病情进展快、无特效治疗和收治条件有限等困难，通过健全疫情应急处理机制、启动卫生战备预案，按照管理传染源、切断传播途径、保护易感人群的方法，严格管理、科学治疗，取得了无院内交叉感染和无输入性病例发生的成绩，成功探索并实践了突发性传染病的防治模式。     

The quality of communication between parents and adolescent children in the case of parental cancer.

BACKGROUND: This study was designed to investigate: (i) parent-adolescent communication in families of cancer patients; (ii) relationships between parent-adolescent communication and posttraumatic stress symptoms (PTSS) in adolescent children; and (iii) associations between parents' illness characteristics and parent-adolescent communication. PATIENTS AND METHODS: A total of 212 adolescents completed the Impact of Event Scale and Parent-Adolescent Communication Scale. RESULTS: Adolescents communicated less openly with mothers with cancer than controls with mothers; this was the only significant difference with the reference group. Daughters communicated more openly with ill parents than with healthy parents. More open communication with healthy parents was related to fewer PTSS in daughters. More problem communication with both parents was related to more PTSS in both sons and daughters. Sons reported more problems in communication with ill parents in case of more intensive treatment or recurrent disease. Daughters experienced less open communication with both parents when ill parents received more intensive treatment. Time since diagnosis was not related to parent-adolescent communication. Multivariate analyses showed that communication patterns specifically affected PTSS of daughters. Problem communication with the healthy parent was the strongest predictor of intrusion while problem communication with the ill parents was the strongest predictor of avoidance. CONCLUSIONS: Parent-adolescent communication in families of cancer patients differs little from that in families not confronted with parental cancer. Problem communication outweighed lack of openness with respect to development of PTSS. Recurrent disease and intensive treatment regimens affected parent-adolescent communication negatively.     

Impact of EGFR expression on colorectal cancer patient prognosis and survival.

BACKGROUND: Epidermal growth factor receptor (EGFR) is overexpressed in many types of cancers, especially colorectal cancer (CRC), and seems to reflect more aggressive histological and clinical behaviors. The aim of this study was to evaluate EGFR immunohistochemical reactivity in CRC biopsies, and to analyze its relationship with various histological and clinical characteristics and survival. PATIENTS AND METHODS: A composite EGFR score, obtained by multiplying the grade (% positive cells) by the intensity of labeling (0-9) was used to define patients with low or high EGFR expression whose clinicopathological features were then compared. Univariate tests and multivariate Cox proportional hazards model were applied for data analysis. RESULTS: Tissue sections from 150 CRC patients with a median follow-up of 40 months were examined. Median patient age at diagnosis was 70 years (range 38-89 years). EGFR reactivity was positive for 143 patients (97%) and high for 118 (80%). According to multivariate analysis, EGFR overexpression was significantly associated with tumor stage, with a higher percentage of EGFR overexpression in T3 than T4 (P=0.003) and not with overall survival. CONCLUSIONS: EGFR was overexpressed in this CRC patient population and was significantly associated with TNM (tumor-node-metastasis) stage T3. In the context of a new therapeutic strategy using EGFR-targeted therapies, although EGFR remains a controversial prognostic factor, this expression-stage association may play a crucial role in a decision to initiate an adjuvant treatment.     

脑卒中患者医院感染调查分析及护理对策

目的为了解脑卒中患者医院感染的发生和易感因素,有针对性地采取预防措施. 方法调查2001年1月～2002年12月,收住的202例脑卒中患者的医院感染,并设对照组进行对照分析. 结果发生医院感染34例、42例次,感染率为16.83%,例次感染率为20.79%;感染部位以下呼吸道和泌尿道感染最常见,构成比分别为38.1%、30.95%,感染组、非感染组在应用抗生素、侵入性操作、年龄、住院天数比较,两组均存在着显著性差异.结论脑卒中患者医院感染发生率明显高于我院两年平均医院感染率4.03%,明显高于卫生部医院感染管理规范中医院感染发生率应在3%～8%的规定范围,脑卒中患者是医院感染的高危人群,应成为重点防护对象.