糖心舒合剂对糖尿病性心脏自主神经病变心率变异性的影响

目的：观察糖心舒合剂对糖尿病性心脏自主神经病变患者的治疗作用。方法：60例患者在口服达美康同时,治疗组(30例)加服中药糖心舒合剂,对照组(30例)加维生素和弥可保治疗,疗程12周。观察两组治疗前后血糖、血脂、心率变异性(HRV)指标的变化。结果：总有效率治疗组为90．0％,对照组为66．7％,两组比较差异有显著性(P<0．05);治疗组在降低空腹血糖、餐后2h血糖、血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平及提高高密度脂蛋白胆固醇含量、HRV指标方面均优于对照组(P<0．05)。结论：糖心舒合剂可有效控制血糖,改善微循环障碍,对糖尿病性心脏自主神经病变有一定的疗效。     

寻常性银屑病患者血脂、TXB_2、6-酮-PGF_(1α)和血小板聚集功能的检测

银屑病患者伴发心血管疾病者明显增多，为探讨其机理，对１００例作血脂检测，发现ＴＣ、ＴＧ和β ＬＰ均明显增高。３２例作ＴＸＢ２和６ 酮 ＰＧＦ１α检测，前者为正常人的２．５倍，后者为１．８倍。７５例作血小板聚集功能检测，也明显增高。提示高脂血症、ＴＸＢ２和６ 酮 ＰＧＦ１α增高以及血小板聚集功能增高是银屑病伴发心血管疾病的病理基础     

翻白草水提液对2型糖尿病胰岛素抵抗大鼠糖脂代谢的影响

目的:观察翻白草水提取物对2型糖尿病胰岛素抵抗大鼠糖脂代谢的影响.方法:采用3周龄Wistar大鼠,高脂喂养16周加腹腔小剂量注射链脲佐菌素(STZ)的方法建立2型糖尿病胰岛素抵抗(IR)动物模型,随机分为4组:翻白草高、低剂量组(400,200 mg?kg-1)、吡格列酮组(4.05 mg?kg-1)及模型组,每组7只.另取标准饲料喂养大鼠7只为正常组.比较各药物干预4周后对2型糖尿病IR大鼠空腹血糖(FBG)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)及游离脂肪酸(FFA)影响.结果:翻白草提取物和西药组均可显著降低大鼠FBG,TG,TC,LDL,FFA水平,升高HDL水平(P＜0.05).结论:翻白草对2型糖尿病胰岛素抵抗大鼠的空腹血糖及血脂水平有一定调节作用.     

加味四妙勇安汤对冠心病患者血脂和血清高敏C反应蛋白的影响

目的 研究加味四妙勇安汤对冠心病(CHD)患者血脂和高敏C反应蛋白(hs-CRP)的影响.方法 将患者随机分为3组,均给予常规治疗,治疗组予加味四妙勇安汤口服,阿托伐他汀干预组予阿托伐他汀10mg晚餐后服,疗程均为6周.常规治疗组仅给予常规治疗.比较3组治疗前后血脂及血浆hs-CRP水平.结果 治疗组及阿托伐他汀干预组治疗后血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇和hs-CRP水平下降程度均优于常规治疗组,组间疗效相近.结论加味四妙勇安汤对冠心病患者具有调脂和抗炎作用.     

Stratum corneum lipid morphology and transepidermal water loss in normal skin and surfactant-induced scaly skin

Stratum corneum lipid morphology was evaluated using attenuated total reflectance infrared spectroscopy (ATR-IR) in normal skin and surfactant-induced scaly skin to evaluate skin barrier function. To evaluate the degree of order of the intercellular lipid alkyl chain conformation, we measured the wavenumbers (frequency shifts) of the symmetrical and asymmetrical C-H stretching vibrations observed at approximately 2850 cm^–1 and 2920 cm^–1, respectively. There was a correlation between the wave-number and transepidermal water loss in normal skin. However, no difference was observed in surfactant-induced scaly skin from the baseline value in the wavenumbers of the C-H vibrations. These results suggest that in normal skin, lipid morphology plays an important role in the barrier function of the stratum corneum. However, the decline in barrier function in scaly skin is not due to conformational disorder of the lipid alkyl chain.     

Sea-blue histiocyte syndrome in bone marrow secondary to total parenteral nutrition including fat-emulsion sources: a clinicopathologic study of seven cases

Bone marrow examination revealed a lipid-laden histiocytosis in seven patients undergoing long-term total parenteral nutrition necessitated by extensive short-bowel surgical resection. Clinical abnormalities occurred during this treatment which required bone marrow examination. These included hepatosplenomegaly and peripheral blood cytopenia; the median time to the detection of these abnormalities was 64 months.   The most striking change within the bone marrow was the presence of many pigment-laden histiocytes which had the typical morphology of sea-blue histiocytes seen in the so-called idiopathic sea-blue histiocyte syndrome. The occurrence of sea-blue histiocytosis in the bone marrow in association with long-term parenteral nutrition for short-bowel syndrome has not, to our knowledge, been reported previously and should now be considered in the differential diagnosis of bone marrow sea-blue histiocytosis.     

Comparison of the metabolic effects of long-term treatment with pindolol or atenolol by hypertensive patients

Summary The effects of plasma lipids, blood glucose, and serum total cholesterol, LDL-cholesterol, VLDL-cholesterol, 6-month period were studied in 18 patients with essential hypertension.There were no significant changes in the concentration of serum total cholesterol. LDL-cholesterol, VLDL-cholesterol, and triglycerides during treatment periods with pindolol or atenolol, although there was a tendency to higher triglyceride levels during atenolol treatment.The serum HDL-cholesterol levels were significantly lower after 6 months of therapy with atenolol than before treatment, but HDL-cholesterol levels increased slightly during pindolol treatment. The ratio of HDL-cholesterol to total cholesterol decreased significantly during 6 months of treatment with atenolol.Fasting blood glucose concentrations did not change significantly during 6 months of treatment with pindolol or atenolol, but during oral glucose tolerance test, blood glucose values at 60 min were raised after pindolol therapy. Serum insulin levels during oral glucose tolerance test at 120 min were decreased after pindolol therapy, but no significant changes were found in C-peptide levels during treatment periods.     

The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials

AimsTo systematically evaluate the evidence regarding the effects of foods on LDL cholesterol levels and to compare the findings with current guidelines.Data synthesisFrom inception through June 2019, we searched PubMed, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials for guidelines, systematic reviews, and RCTs (for coffee intake only) of at least 13 days duration. Additionally, we searched Trip database for guidelines from 2009 through Oct 2019. Language was restricted to English. The strength of evidence was evaluated using The Grading of Recommendations Assessment, Development, and Evaluation (GRADE). A total of 37 guidelines, 108 systematic reviews, and 20 RCTs were included. With high evidence, foods high in unsaturated and low in saturated and trans fatty acids (e.g. rapeseed/canola oil), with added plant sterols/stanols, and high in soluble fiber (e.g. oats, barley, and psyllium) caused at least moderate (i.e. 0.20–0.40 mmol/L) reductions in LDL cholesterol. Unfiltered coffee caused a moderate to large increase. Soy protein, tomatoes, flaxseeds, and almonds caused small reductions. With moderate evidence, avocados and turmeric caused moderate to large reductions. Pulses, hazelnuts, walnuts, high-fiber/wholegrain foods, and green tea caused small to moderate reductions, whereas sugar caused a small increase. Other identified foods were either neutral or had low or very low evidence regarding their effects.ConclusionsSeveral foods distinctly modify LDL cholesterol levels. The results may aid future guidelines and dietary advice for hypercholesterolemia.