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??The number of patients with chronic kidney disease??CKD?? has increased year by year??had many of them further progress to end-stage renal disease??ESRD????requiring maintenance dialysis or transplantation??which causes huge social burden??so CKD has become a more and more serious public health issue worldwide. Proteinuria and/or albuminuria is the important independent risk factor of CKD??which have close relationship with CKD??and have been the hotspot in research of the pathogenesis??progression and therapy of CKD.     

Mitochondrial respiratory chain complex IV deficiency complicated with chronic intestinal pseudo‐obstruction in a neonate

A female infant born at 36 weeks gestational age with birthweight 2135 g, and who developed respiratory disorder, hyperlactacidemia and hypertrophic cardiomyopathy after birth, was admitted to hospital at 3 days of age. After admission, bilious emesis, abdominal distention, and passage disorder of the gastrointestinal tract were resistant to various drugs. Exploratory laparotomy was performed at 93 days of age, but no organic lesions were identified and normal Meissner/Auerbach nerve plexus was confirmed, which led to a clinical diagnosis of chronic intestinal pseudo‐obstruction (CIPO). She was diagnosed with mitochondrial respiratory chain complex IV deficiency on histopathology of the abdominal rectus muscle and enzyme activity measurement. This is the first report of a neonate with mitochondrial respiratory chain complex deficiency with intractable CIPO. CIPO can occur in neonates with mitochondrial respiratory chain disorder, necessitating differential diagnosis from Hirschsprung disease.     

Bubbly and cystic appearance in chronic lung disease: Is this diagnosed as Wilson–Mikity syndrome?

Wilson–Mikity syndrome (WMS) was first reported in 1960 by Wilson and Mikity. They described preterm infants who developed areas of cystic emphysema in the first month of life with subsequent progression to chronic lung disease (CLD) of infancy, although these infants did not exhibit early respiratory distress, such as respiratory distress syndrome (RDS). This condition was widely accepted over the next 20 years, but WMS is now rarely mentioned and is commonly considered an anachronism. In Japan, CLD is classified into six types according to the presence of RDS and/or intrauterine inflammation and appearance on chest X‐ray. One type of CLD (type III, which accounts for 13.5% of all CLD) is defined as history of intrauterine inflammation and the typical bubbly and cystic appearance on chest X‐ray described in the original report of WMS. There is insufficient evidence to determine whether WMS exists or whether WMS is relatively common only in Japan and not in other countries. It is important, however, to distinguish this type of CLD from other types because the strategy for the prevention or treatment of CLD should be different according to its origin, cause, and risk factors.     

真武汤合生脉散治疗慢性充血性心力衰竭28例临床观察

目的:观察真武汤合生脉散治疗慢性充血性心力衰竭的临床疗效。方法:选择56例诊断明确的慢性充血性心力衰竭患者,经知情同意后,随机分为治疗组与对照组,各28例。对照组运用西药常规进行治疗,治疗组在对照组基础上加用真武汤合生脉散水煎剂治疗,疗程4周。结果:治疗组临床症状改善总有效率为82.14%,对照组64.29%;心衰计分治疗组有效率85.71%,对照组有效率67.85%。结论:真武汤合生脉散可较快缓解慢性充血性心力衰竭临床症状,改善心功能。