Muscle and tendon connective tissue adaptation to unloading,exercise and NSAID

The extracellular matrix network of skeletal muscle and tendon connective tissue is primarily composed of collagen and connects the muscle contractile protein to the bones in the human body. The mechanical properties of the connective tissue are important for the effectiveness of which the muscle force is transformed into movement. Periods of unloading and exercise affect the synthesis rate of connective tissue collagen protein, whereas only sparse information exits regarding collagen protein degradation. It is likely, though, that changes in both collagen protein synthesis and degradation are required for remodeling of the connective tissue internal structure that ultimately results in altered mechanical properties of the connective tissue. Both unloading and exercise lead to increased production of growth factors and inflammatory mediators that are involved in connective tissue remodeling. Despite the fact that non-steroidal anti-inflammatory drugs seem to inhibit the healing process of connective tissue and the stimulating effect of exercise on connective tissue protein synthesis, these drugs are often consumed in relation to connective tissue injury and soreness. However, the potential effect of non-steroidal anti-inflammatory drugs on connective tissue needs further investigation.     

福辛普利对原发性高血压患者肾功能和左室肥厚的影响

目的探讨福辛普利对原发性高血压肾功能和左室肥厚的影响。方法应用无创性动态血压监测仪监测原发性高血压病患者24h血压的变化,并测定血、尿β2微球蛋白(β2-MG)、尿微量白蛋白(MCA)、肌酐(Cr)和尿素氮(BUN),彩色多普勒显像仪测量室间隔厚度(IVST)、左室后壁厚度(PWT)和左室舒张末期内径(LVDd),并计算左室质量指数(LVMI)。比较治疗前后以上各指标的变化。结果治疗后24h血压及昼夜血压均低于治疗前(P<0.01);治疗后IVST、PWT和LVMI均较治疗前降低,差异均有统计学意义(P<0.05);治疗后血尿β2-MG及尿MCA水平低于治疗前,差异均有统计学意义(P<0.05)。结论福辛普利在有效降低血压的同时,对高血压病患者心肾功能的损害可起到保护作用。     

鼻窦CT评估腺样体切除术对儿童慢性鼻窦炎的影响

目的探索儿童慢性鼻窦炎的严重程度与腺样体大小的关系,分析腺样体切除术后儿童慢性鼻窦炎的预后情况。方法选取2018年8月至2018年12月于山东省立医院东院耳鼻喉科行腺样体切除术的119例患儿作为研究对象,术前通过电子鼻咽喉镜评估腺样体的大小,依据腺样体组织阻塞后鼻孔的面积将所有患者分为3组:A组(阻塞后鼻孔<70%,n=23),B组(阻塞后鼻孔70%~90%,n=42),C组(阻塞后鼻孔>90%,n=54)。分别于术前及术后3个月行鼻窦CT检查,利用Lund-Mackay评分评估鼻窦炎的严重程度,并比较手术前后患儿鼻窦炎的变化情况。结果A、B、C组Lund-Mackay评分分别为(3.91±3.44)分、(4.02±4.07)分、(7.67±6.46)分,C组与A、B组比较差异有统计学意义(P<0.05)。腺样体切除术后患儿的Lund-Mackay评分低于术前,差异具有统计学意义。结论腺样体的大小会影响鼻窦炎的严重程度,腺样体切除手术有助于儿童慢性鼻窦炎的恢复。     

THE EFFECTS OF MONOTHERAPY OR COMBINED THERAPY WITH AN ANGIOTENSIN CONVERTING ENZYME INHIBITOR FOLLOWING INITIAL TREATMENT WITH CALCIUM CHANNEL BLOCKERS ON RESIDUAL CARDIOVASCULAR ABNORMALITIES

The effects of sequential therapy with angiotensin-converting enzyme inhibitor (cilazapril) on left ventricular (LV) mass, LV diastolic function, and carotid artery distensibility were evaluated in 90 hypertensive patients whose blood pressure controlled below 140/90 mmHg with a calcium channel blocker monotherapy. The possibility of predicting the efficacy of cilazapril based on evaluation of biochemical and genetic markers of the renin-angiotensin system was examined. Before cilazapril therapy, LV diastolic function and carotid artery distensibility were significantly impaired in 32 patients with residual LV hypertrophy compared with patients without LV hypertrophy. Cilazapril improved the LV mass in these patients with LV hypertrophy and improved LV diastolic function in a subset of 20 patients with elevated plasma renin activity. Patients with residual LV hypertrophy accompanied by cardiovascular functional abnormalities. Subsequent treatment with cilazapril significantly improved LV morphology and function in those with residual LV hypertrophy or elevated plasma renin activity.