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51.
Bruce Bennett Alison M. Croll Linda A. Robbie Richard Herriot 《British journal of haematology》1997,99(3):570-574
Tumour cells may express urokinase type plasminogen activator (u-PA). This may influence the invasive properties of the cells but has seldom been implicated in production of a systemic bleeding state. Two patients are described in whom severe bleeding occurred in association with disseminated malignancies. Thrombin generation was little disturbed and platelet numbers were insufficient to account for the bleeding. Florid plasmin generation was evident in the circulation and the fibrinolytic inhibitor tranexamic acid controlled the bleeding well. Free active u-PA was demonstrated in the circulation and u-PA antigen on the malignant cells which invaded the marrow of one of the patients. Tumour cell u-PA may occasionally be responsible for a bleeding state. 相似文献
52.
53.
师爱枝 《山西职工医学院学报》2004,14(4):9-10
目的:观察危重型肾功能衰竭合并高危出血患者选择抗凝药物进行血液透析治疗的效果。方法:应用吉派林(低分子肝素钠)作为抗凝剂进行血液透析。结果:129例病人进行血液透析386次,均没有出血发生。结论:吉派林在高危出血患者血液透析中使用方便,安全,效果良好。 相似文献
54.
目的 探讨生长抑素治疗食管胃底静脉曲张破裂出血的临床效果。方法 应用奥曲肽治疗食管胃底静脉曲张破裂出血患者41例,并与垂体后叶素治疗的32例及三腔管治疗的25例进行对照。观察3组平均止血时间、24h止血率以及治疗前后门静脉主干直径、血流速度、血流量的变化。结果 奥曲肽治疗组、垂体后叶素治疗组、三腔管治疗组平均止血时间分别为194.27±28.88min、358.11±151.43min、134.71±32.12min,24h止血率分别为63.41%、37.50%、72%。奥曲肽治疗组止血率显著高于垂体后叶素治疗组(P<0.01)。奥曲肽治疗前后门静脉内径分别为10.86±0.41mm、13.84±0.35mm,二者有显著差异。奥曲肽治疗后其门静脉血流速度,血流量与治疗前相比较也有显著差异(P<0.01,P<0.05)。结论 奥曲肽能使门脉内径相对缩小、血流量减少和血流速度加快,从而使门脉压力降低达到止血的目的。 相似文献
55.
冲洗液温度对前列腺切除术后出血的影响 总被引:17,自引:0,他引:17
目的 研究冲洗液温度对前列腺切除术后出血的影响。方法 耻骨上前列腺切除术患者80例,年龄60~82(平均67.4±10.3)岁,随机分为两组各40例。A组采用20℃的冲洗液冲洗膀胱,B组采用37℃的冲洗膀胱。两组所有患者均于膀胱冲洗前抽静脉血,分别测定其在20℃和37℃状态下的激活部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)。同时比较两组术后出血量、冲洗总液量、血尿时间、寒冷反应及膀胱痉挛发生率,结果 检测80例患者血APTT,PT,TT均存在显著差异(P<0.001;冲洗总液量分别是(47883±±8953)ml和(19741±5490)mL,P<0.001;尿液转清时间分别是(47.5±16.9)h和(19.8±5.7)h,P相似文献
56.
57.
This is a retrospective study of the outcome of surgical procedures in patients who were Jehovah's Witnesses. Over a 75-month period, 58 Jehovah's Witness patients had 78 surgical procedures at the Vancouver General Hospital. Three patients had preexisting anaemia of less than 100 g.L-1 haemoglobin. Postoperative haemoglobin concentration decreased below 50 g.L-1 in three patients. One patient had a postoperative haemoglobin of 34 g.L-1 (haematocrit 10.1 per cent) and survived. One patient died from uncontrollable postoperative haemorrhage. Perioperative morbidity was not uncommon, including significant hypotension (eight cases), cardiac arrhythmias (six), myocardial ischaemia (three), excessive bleeding (four), postoperative nausea or syncope (four), and wound or urinary tract infection (four). 相似文献
58.
Marius J. van der Mooren Antonius G. J. M. Hanselaar George F. Borm Rune Rolland 《Maturitas》1994,20(2-3):175-180
Objective: To describe changes in the withdrawal bleeding pattern and endometrial histology during a sequential 17β-estradiol —dydrogesterone regimen in postmenopausal women. Design: Open-label, non-comparative, prospective study. Setting: Gynecological outpatient department of a university hospital. Patients: Twenty-seven healthy nonhysterectomized postmenopausal women. Interventions: Continuous micronized 17β-estradiol supplementation, 2 mg daily, and cyclic administration of dydrogesterone, 10 mg daily for the first half of each 28 day treatment cycle. Main Outcome Measures: Changes in the characteristics of the withdrawal bleeding pattern and the endometrial biopsy histology during 2 years of treatment. Results: The initial withdrawal bleeding was comparable to normal menstruation with respect to amount and duration. During the 2 years of treatment the bleeding showed a significant tendency to become shorter with less blood loss. This was mainly the result of the decrease (P < 0.001) in the number of days per cycle with bleeding grade II (normal menstruation). None of the women developed endometrial hyperplasia, and in almost all women the given hormone replacement therapy regimen induced secretory or atrophic changes of the endometrium. Conclusions: This sequential 17β-estradiol —dydrogesterone regimen can be regarded as safe with respect to the prevention of endometrial disease and appeared to foster patient compliance. 相似文献
59.
目的:探讨产妇抑郁对泌乳与产后流血的影响。方法:对309例产妇采用自评抑郁量表评分,分成产后抑郁组和对照组,测评泌乳指标、产后流血的差异。结果:抑郁组产妇泌乳始动时间迟,产后24小时泌乳者仅13例;泌乳量少,产后72小时泌乳量多者仅13例;抑郁组产妇产后流血量多,与对照组相比差异有显著性。结论:产妇抑郁对泌乳与产后流血有不利影响,应加强对产妇进行心理健康指导。 相似文献
60.
Zupi E Sbracia M Marconi D Alò P Atzei G Brazolin T Arduini D Romanini C 《American journal of reproductive immunology (New York, N.Y. : 1989)》2000,44(3):153-159
PROBLEM: Tumor necrosis factor-alpha (TNFalpha) is produced by the endometrium, and it has been shown that this cytokine has cyclic variations through the menstrual cycle. METHOD OF STUDY: In this study we assessed TNFalpha, estradiol and progesterone levels in the endometrium and serum of 21 patients with recent abnormal uterine bleeding (AUB). Eleven women showed histological diagnosis of endometrial hyperplasia, and ten women showed normal endometrium. RESULTS: The TNFalpha value in the serum of patients with hyperplasia and in normal endometrium did not show significant differences (64.8 +/- 21.4 vs 77.6 +/- 14.8 pg). The amounts of TNFalpha released by hyperplastic endometrial tissue were significantly higher than in control patients (258.8 +/- 78.0 vs 140.6 +/- 79.8 pg/g; P < 0.001). Immunohistochemistry of hyperplastic endometria showed a stronger staining than normal ones. Serum E2 levels in patients with hyperplastic endometrium were 49.5 +/- 31.6 ng/mL, and in controls were 107.3 +/- 66.0 ng/mL. The levels of estradiol released by hyperplastic endometria were significantly lower than in normal endometria (152.7 +/- 60.0 vs 279.9 +/- 178.7 ng/g; P < 0.003). CONCLUSIONS: Hyperplastic endometria produce higher amounts of TNFalpha with respect to controls. These findings may explain the frequent bleeding observed in the patients with endometrial hyperplasia, since TNFalpha promotes apoptosis and endometrial shedding. 相似文献