全文获取类型
收费全文 | 66724篇 |
免费 | 5769篇 |
国内免费 | 2001篇 |
专业分类
耳鼻咽喉 | 504篇 |
儿科学 | 983篇 |
妇产科学 | 518篇 |
基础医学 | 5025篇 |
口腔科学 | 1021篇 |
临床医学 | 10721篇 |
内科学 | 7349篇 |
皮肤病学 | 270篇 |
神经病学 | 9488篇 |
特种医学 | 17117篇 |
外国民族医学 | 17篇 |
外科学 | 4752篇 |
综合类 | 7232篇 |
现状与发展 | 5篇 |
一般理论 | 1篇 |
预防医学 | 1413篇 |
眼科学 | 726篇 |
药学 | 3514篇 |
21篇 | |
中国医学 | 808篇 |
肿瘤学 | 3009篇 |
出版年
2024年 | 185篇 |
2023年 | 912篇 |
2022年 | 2139篇 |
2021年 | 2935篇 |
2020年 | 2582篇 |
2019年 | 2354篇 |
2018年 | 2298篇 |
2017年 | 2502篇 |
2016年 | 2619篇 |
2015年 | 2546篇 |
2014年 | 4534篇 |
2013年 | 4170篇 |
2012年 | 3940篇 |
2011年 | 4415篇 |
2010年 | 3691篇 |
2009年 | 3781篇 |
2008年 | 3766篇 |
2007年 | 3503篇 |
2006年 | 3236篇 |
2005年 | 2976篇 |
2004年 | 2399篇 |
2003年 | 1967篇 |
2002年 | 1569篇 |
2001年 | 1426篇 |
2000年 | 1166篇 |
1999年 | 980篇 |
1998年 | 927篇 |
1997年 | 831篇 |
1996年 | 790篇 |
1995年 | 646篇 |
1994年 | 541篇 |
1993年 | 449篇 |
1992年 | 358篇 |
1991年 | 272篇 |
1990年 | 205篇 |
1989年 | 166篇 |
1988年 | 133篇 |
1987年 | 112篇 |
1986年 | 88篇 |
1985年 | 91篇 |
1984年 | 68篇 |
1983年 | 43篇 |
1982年 | 47篇 |
1981年 | 33篇 |
1980年 | 30篇 |
1979年 | 27篇 |
1978年 | 11篇 |
1977年 | 12篇 |
1976年 | 14篇 |
1973年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
231.
Daniel A. Finelli Gregory C. Hurst Holly A. Frank Rao P. Gullapali Anthony Apicella 《Journal of magnetic resonance imaging : JMRI》1997,7(4):731-738
The purpose of this study was to analyze the effect of several magnetization transfer (MT) pulse and T1-weighted spin-echo (SE) sequence parameters on lesion-to-background contrast, using a simple tissue phantom emulating the T1 relaxation and MT properties of gadolinium-enhanced brain lesions. Eggbeaters (Nabisco Inc., East Hanover, NJ) liquid egg product was doped with gadolinium in six concentrations from .0 to 1.0 mmol and cooked. The gadolinium-doped egg phantom and normal volunteer brains were studied using an SE sequence with TE = 20 msec and high power, pulsed, off-resonance MT saturation. The effects of MT pulse frequency offset (1,000–6,000 Hz), sequence repetition time (TR = 500–1,000 msec, with MT power held constant), and slice-select flip angle (60–120 degrees) on the magnetization transfer ratio (MTR) and the simulated lesion-to-background contrast were determined at the different “Intralesion” gadolinium concentrations. The MTR and lesion-to-background contrast of all materials were greatest at narrow MT pulse frequency offsets. There was an inverse relationship between gadolinium concentration and MTR and a positive correlation between the gadolinium concentration and lesion-to-background (L/B) contrast, a weak negative correlation between slice-select flip angle and L/B, and a negative correlation between TR and L/B. The relaxation properties and MT behavior of the egg phantom are close to that expected for enhancing brain lesions, allowing a rigorous analysis of several variables affecting lesion-to-background contrast for high MT power, T1-weighted SE sequences. 相似文献
232.
C. M. Lazaro W. Y. Guo M. Sami T. Hindmarsh K. Ericson A. L. Hulting J. Wersäll 《Neuroradiology》1994,36(2):111-114
In a group of 69 patients with pituitary tumours, 12 were found to have evidence of intratumoral haemorrhage on MRI, characterized by high signal intensity on short TR/TE sequences. This was verified in all but 1 patient. The majority of the bleedings occurred in macroadenomas. Five (42%) were prolactinomas and 4 (33%) were non-functioning adenomas. There were 2 GH- and 1 ACTH-secreting tumours. All 5 patients with prolactinomas were on bromocriptine medication. Two of the patients had a clinical picture of pituitary apoplexy. The haemorrhage was not large enough to prompt surgery in any of the patients. However, surgical verification of the diagnosis was obtained in 5 cases, while 6 patients were examined with follow-up MRI. 相似文献
233.
C.C.-W. YU P.A. HALL C.D.M. FLETCHER R.S. CAMPLEJOHN N.H. WASEEM D.P. LANE D.A. LEVISON 《Histopathology》1991,19(1):29-34
Forty-two cases of haemangiopericytoma were studied retrospectively using immunohistochemical staining with PC10, a monoclonal antibody to PCNA. The percentage of tumour cells with positive staining for PCNA was found to correlate well with histological grading. Clinical follow-up data were available in 25 adults and showed no known deaths in 11 cases with a low proportion (less than 14%) of positive cells. Out of 14 cases with a high number (greater than or equal to 14%) of positive cells, seven patients are known to have died, two had metastases, and in a further two there have been multiple recurrences of tumour. DNA flow cytometry was performed on 26 cases but this showed no correlation with PC10 staining or clinical outcome. Staining with PC10 may be of particular value in the identification of patients at greatest risk of rapid tumour metastasis and early death. 相似文献
234.
H. S. Markus C. B. Bunker K. Kouris D. C. Costa M. J. Harrison 《Journal of neurology》1992,239(7):363-366
Summary Conventional imaging with computed tomography (CT) and magnetic resonance imaging (MRI) may show abnormalities in central nervous system Behcet's syndrome but is normal in some cases. Recently in two cases positron emission tomography has shown abnormalities in blood flow and glucose metabolism far more extensive than the abnormalities seen on CT and MRI scans in the same patients. We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy. This technique may aid the diagnosis of cerebral involvement in Behcet's syndrome, although the cause and incidence of the perfusion deficits need further evaluation. 相似文献
235.
Summary
The introduction of fast gradient systems allows a reliable visualization of the extracranial carotid vessels by the magnetic
resonance angiography (MRA) which meanwhile is implemented into clinical routine. By the mainly applied time-of-flight (TOF)
technique, vessels can be imaged without contrast agent (CA). Due to the application of ultra-fast gradient-echo-sequences,
the first-pass evaluation of an intravenous bolus-injection of Gadolinium in the carotids from the aortic arch up to the skull
base can be performed in less than 30 s. In this study, advantages and disadvantages of both techniques are discussed. For
a qualitatively optimal contrast enhanced MRA (CE-MRA) timing parameters like injection delay, flow rate and the adjustment
of sequence parameters have to be considered in relation to the fast venous return from the sinus to the jugular veins. First,
the optimal time point of the data acquisition have been determined at a model and with a computer simulation in reference
to the presence of CA in the arteries. As a result, 90 % of the contrast contribution is defined by 16 % of the symmetrically
acquired central k-space lines. A measuring protocol for clinical use was obtained by a gradual variation of spacial resolution,
measuring time and CA-injection parameters and was proved in normal volunteers and patients. An exact determination of the
bolus-arrival-time by means of a test-bolus injection was acquired. The best qualitative results were achieved by a double-dose
injection at 2 ml/s injection rate. The temporal reserves of ultra-fast sequences should be invested in the improvement of
the spatial resolution. To date, further investigations related to the problem of optimal CA-application may improve the potentials
of CE-MRA procedures.
相似文献
236.
Nancy P. Caraway Gregg A. Staerkel Christina V. Fanning Datla G. Varma Raphael E. Pollock 《Diagnostic cytopathology》1994,11(3):255-261
The gross and microscopic appearances of aspirates from ten intramuscular myxomas are reported. The specimens were obtained from seven women and three men, ages 43 to 75, who had tumors involving the muscles of the thigh (7), upper arm (2), and forearm (1). Magnetic resonance (MR) imaging performed in six of the ten cases revealed well-defined, sharply demarcated tumors exhibiting low signal intensity relative to muscle on the T1-weighted images. The tumors were hyperintense to muscle on T2-weighted images. All aspirated tissues were clear, tenacious, and viscous. Smears contained few spindled and histiocytoid cells in an abundant mucoid background. Spindle cells demonstrated long cytoplasmic processes that in areas intertwined to form fibrillar tangles. Nuclei were oval to spindled with fine chromatin and inconspicuous nucleoli. Capillaries were sparse with simple (nonplexiform) branching. The differential diagnosis of myxoid lesions of the extremities includes benign entities such as myxoid schwannoma and neurofibroma, mesenchymal repair, and ganglion cyst, as well as malignant neoplasms such as myxoid liposarcoma, fibrosarcoma, malignant fibrous histiocytoma, and extraskeletal chondrosarcoma. The findings of this study revealed that, although the cytologic features were suggestive of intramuscular myxoma, a definitive diagnosis was often difficult, owing to scant cellularity and lack of distinctive cytologic features. The MR imaging findings may be utilized as an adjunct to the cytologic features to more confidently suggest a diagnosis of intramuscular myxoma. Diagn Cytopathol 1994;11:255–261. © 1994 Wiley-Liss, Inc. 相似文献
237.
Florian A Kagerer Jeff J Summers Winston D Byblow Bruce Taylor 《Movement disorders》2003,18(8):919-927
In 6 patients with Parkinson's disease (PD) and 6 age-matched controls, transcranial magnetic stimulation was applied at 56 regions over the motor cortex and premotor cortex of each hemisphere, with the first dorsal interosseous (FDI) muscle of both hands activated at 15% maximum voluntary contraction during stimulation. For each site, motor evoked potential (MEP) landmarks were recovered, including MEP amplitude, MEP onset latency, and silent period duration. Scaled MEP amplitudes were used to construct individual cortical maps of the FDI muscles. The maps revealed an anterior displacement of the muscle representation in PD patients. This anterior shift over motor cortical areas may reflect increased contributions of corticocortical connections between motor cortex and premotor cortical areas, possibly enhanced by the visual feedback aspect of the task. These alterations may reflect adaptations to the impairments in striatocortical circuits in PD. 相似文献
238.
239.
Ronald G. Pratt Jie Zheng Brent K. Stewart Yoseph Shiferaw Anthony J. McGoron Ranasinghage C. Samaratunga Stephen R. Thomas 《Magnetic resonance in medicine》1997,37(2):307-313
A limited flip angle gradient-echo 3D volume acquisition imaging protocol for mapping partial pressure of oxygen (pO2) in perfluorocarbon compounds (PFCs) at low field (0.14 T) is presented. The pO2 measurement method is based on the paramagnetic effect of dissolved molecular oxygen (O2) which reduces the PFC 19F T1? Specific objectives related to imaging of PFCs through use of the protocol include improved image signal-to-noise characteristics and elimination of 19F chemical shift artifacts. A parametric Wiener deconvolution filtering algorithm is used for suppression of 19F chemical shift artifacts. Application of the protocol is illustrated in a series of calculated pO2 maps of a gas equilibrated, multi-chamber phantom containing perfluorotributylamine (FC-43). The utility of the protocol is demonstrated in vivo through images of a commercially available perfluorocarbon based blood substitute emulsion containing FC-43 sequestered in the liver and spleen of a rat. 相似文献
240.