全文获取类型
收费全文 | 414277篇 |
免费 | 36154篇 |
国内免费 | 15176篇 |
专业分类
耳鼻咽喉 | 2553篇 |
儿科学 | 7999篇 |
妇产科学 | 4719篇 |
基础医学 | 48759篇 |
口腔科学 | 8664篇 |
临床医学 | 38772篇 |
内科学 | 57446篇 |
皮肤病学 | 5381篇 |
神经病学 | 24468篇 |
特种医学 | 9573篇 |
外国民族医学 | 70篇 |
外科学 | 32016篇 |
综合类 | 60496篇 |
现状与发展 | 44篇 |
一般理论 | 36篇 |
预防医学 | 30944篇 |
眼科学 | 8219篇 |
药学 | 72007篇 |
148篇 | |
中国医学 | 19667篇 |
肿瘤学 | 33626篇 |
出版年
2024年 | 1109篇 |
2023年 | 6011篇 |
2022年 | 12069篇 |
2021年 | 15480篇 |
2020年 | 14001篇 |
2019年 | 13603篇 |
2018年 | 13579篇 |
2017年 | 14278篇 |
2016年 | 14414篇 |
2015年 | 14431篇 |
2014年 | 24064篇 |
2013年 | 30591篇 |
2012年 | 23196篇 |
2011年 | 25583篇 |
2010年 | 21472篇 |
2009年 | 20482篇 |
2008年 | 20615篇 |
2007年 | 21379篇 |
2006年 | 19284篇 |
2005年 | 17931篇 |
2004年 | 15329篇 |
2003年 | 13678篇 |
2002年 | 10897篇 |
2001年 | 10054篇 |
2000年 | 8374篇 |
1999年 | 7402篇 |
1998年 | 5897篇 |
1997年 | 5373篇 |
1996年 | 5059篇 |
1995年 | 4709篇 |
1994年 | 4183篇 |
1993年 | 3467篇 |
1992年 | 3151篇 |
1991年 | 2745篇 |
1990年 | 2373篇 |
1989年 | 2091篇 |
1988年 | 2009篇 |
1987年 | 1655篇 |
1986年 | 1364篇 |
1985年 | 1786篇 |
1984年 | 1785篇 |
1983年 | 1131篇 |
1982年 | 1364篇 |
1981年 | 1080篇 |
1980年 | 1020篇 |
1979年 | 838篇 |
1978年 | 666篇 |
1977年 | 533篇 |
1976年 | 559篇 |
1975年 | 402篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
41.
42.
【摘要】 报道临床症状不典型的家族性黑棘皮病1家系。先证者女,4岁,自1周岁时,颈部、腹部出现黑色斑片,近年来逐渐扩大至唇周、躯干前部。腹部皮肤全反式共聚焦显微镜检查可见乳头环下延扭曲及沟壑结构,乳头环内可见中高折光颗粒结构。先证者父亲及祖母既往有类似病史,但随着年龄增长色素沉着自发性消退,仅有局部皮纹增粗。采集先证者及父母、祖母外周血,对先证者外周血DNA行Panel靶向测序,结果显示,先证者存在FGFR3基因14号外显子c.1949A>C(p.Lys650Thr)错义突变,Sanger测序验证证实先证者及其父亲和祖母均存在此突变。诊断:家族性黑棘皮病。 相似文献
43.
Despite preventive efforts, HIV exposure is still a concern for public health. The current prevalence is related to unsafe sex, which is based on socio-cognitive variables. Therefore, information about these variables is required to verify whether the past preventive strategies have been effective and improve the future ones. However, there is not updated information to adjust future preventive interventions. For this reason, this study analyzes trends by gender in Spanish young people over the past two decades in perceived susceptibility to HIV, severity perceived to HIV, condom confidence and the intention of condom use, from 1999 to 2020. For this purpose, 11,665 Spanish young people (from 17 to 40 years old) completed the AIDS Prevention Questionnaire in each year. Following our results, in general, the socio-cognitive variables have revealed an unsatisfactory trend: a low perceived susceptibility to HIV and a behavioral intention that have remained stable or even declined slightly over the past years. Particularly, men are more likely to report a riskier level in socio-cognitive variables although, in the latest evaluations, women would decrease condom use intention largely than men. In general, regarding age, young adult would report better levels of condom confidence, but early youth would get higher results in perceived severity, as well as better scores in the latest evaluations of condom use intention. Considering these results, policies should make an effort in HIV prevention programs, and emphasize the attention to attitudinal beliefs and behavioral intention to improve their effectiveness. 相似文献
44.
45.
目的:探讨D6S1043、D12S391基因座的基因多态性对主动攻击行为的影响。方法:应用聚合酶链反应技术结合毛细管电泳法对114例男性主动攻击行为者(研究组)及120名健康男性(对照组)进行D6S1043、D12S391基因座的基因型及等位基因检测,分析D6S1043、D12S391基因座多态性与主动攻击行为的相关性。结果:研究组D6S1043基因座中12~19基因型频率(13.16%)明显高于对照组(1.67%)(P0.05);两组等位基因频率差异无统计学意义;两组D12S391基因座的基因型及等位基因频率差异无统计学意义。结论:D6S1043基因座中12~19基因型可能主动攻击行为有关。 相似文献
46.
Interstitial cystitis/bladder pain syndrome (IC/BPS) and vulvodynia are chronic pain syndromes that appear to be intertwined from the perspectives of embryology, pathology and epidemiology. These associations may account for similar responses to various therapies. 相似文献
47.
Can EGFR mutation status be reliably determined in pre‐operative needle biopsies from adenocarcinomas of the lung? 下载免费PDF全文
Kim Hein Lindahl Flemming Brandt Sørensen Søren Peter Jonstrup Karen Ege Olsen Siegfried Loeschke 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(4):289-297
The identification of EGFR mutations in non‐small‐cell lung cancer is important for selecting patients, who may benefit from treatment with EGFR tyrosine kinase inhibitors. The analysis is usually performed on cytological aspirates and/or histological needle biopsies, representing a small fraction of the tumour volume. The aim of the present investigation was to evaluate the diagnostic performance of this molecular test. We retrospectively included 201 patients with primary adenocarcinoma of the lung. EGFR mutation status (exon 19 deletions and exon 21 L858R point mutation) was evaluated on both pre‐operative biopsies (131 histological and 70 cytological) and on the surgical specimens, using PCR. Samples with low tumour cell fraction were assigned to laser micro‐dissection (LMD). We found nine (4.5%) patients with EGFR mutation in the lung tumour resections, but failed to identify mutation in one of the corresponding pre‐operative, cytological specimens. Several (18.4%) analyses of the pre‐operative biopsies were inconclusive, especially in case of biopsies undergoing LMD and regarding exon 21 analysis. Discrepancy of mutation status in one patient may reflect intra‐tumoural heterogeneity or technical issues. Moreover, several inconclusive results in the diagnostic biopsies reveal that attention must be paid on the suitability of pre‐operative biopsies for EGFR mutation analysis. 相似文献
48.
49.
50.
Primary cutaneous anaplastic large cell lymphomas with 6p25.3 rearrangement exhibit particular histological features 下载免费PDF全文