手术切除T4期肺癌的临床疗效分析

目的 探讨手术切除T4期肺癌的临床疗效.方法 总结在我院通过手术切除T4期肺癌患者34例资料,对可能影响患者术后生存率的因素（临床因素、病理因素和治疗因素等）进行分析.结果 T4期肺癌患者34例资料术后均存活（存活率100%）,术后1年累计死亡8例（存活率76.5%）,术后3年累计死亡23例（存活率32.4%）,术后5年累计死亡28例（存活率17.6%）.结论 T4期肺癌患者手术预后与年龄、手术切除范围大小、是否有淋巴结转移现象和是否根治性切除有关.     

Mycosis fungoides: A case report

Mycosis fungoides is the commonest cutaneous T cell lymphoma. Clinically it is characterized by patch, plaque, tumor nodules; erythrodermic and poikoilodermous stages which may overlap. Extracutaneous spread takes place in late stages where any organ may be involved. The majority of reported cases are in adult males. A rare case of mycosis fungoides in a 38-year-old female is described. She presented in advance stage of disease with nodules all over the body.     

Differences between the early and advanced stages of rheumatoid arthritis in the expression of EDA-containing fibronectin

In the present study the expression of alternatively spliced synovial EDA-containing FN (EDA-FN) was analyzed in plasma and synovial fluid samples of rheumatoid arthritis (RA) patients with from 2 months to 20 years disease duration. The patient samples were divided into groups: those with early, established, and late progressive radiographic changes as well as those with different disease activity established by a CRP concentration. The expression of EDA-FN was determined by sandwich-type ELISA using a specific anti-EDA monoclonal antibody. The relative amount of EDA-FN in synovial fluid, but not in plasma samples, was significantly lower in the early RA group than in established and late RA. In contrast, its level did not correlate with the CRP concentration. Synovial EDA-FN might be used as a supplemented marker of early RA.     

晚期糖基化终产物受体在心血管疾病中的研究进展

晚期糖基化终产物受体属于细胞表面分子免疫球蛋白超家族中的一个新成员,可与多种配体结合后影响细胞内信号传导、刺激细胞因子释放等从而发挥其生物学效应。已知晚期糖基化终产物受体在糖尿病并发症、心血管疾病、神经系统疾病、肿瘤等疾病中起重要作用。现主要综述其在心血管疾病中的作用。     

Characterization of the allergen filarial tropomyosin with an invertebrate specific monoclonal antibody

Tropomyosins of invertebrates are pan-allergens responsible for wide spread allergic reactions against seafood and arthropods. As invertebrate tropomyosins are highly conserved, helminth tropomyosins are likely to show properties similar to these medically important allergens. Studies with a monoclonal antibody, NR1, raised against tropomyosin of the rodent filarial nematode Acanthocheilonema viteae revealed a B cell epitope common to helminths and marine mollusks, which does not occur in vertebrate tropomyosin. This antibody detected tropomyosin of A. viteae, other filariids, nematodes, trematodes and a cestode, and recognized as well tropomyosin of oyster, squid and octopus, but not of arthropods and vertebrates. Immunohistological analyses of A. viteae, Onchocerca volvulus and other nematodes using NR1 showed that tropomyosin is located in the fibrillar part of the body wall muscles and the uterus, and is also conspicuous in muscles of the pharynx, the vagina and other organs of the nematodes. The abundance of a pan-allergen like tropomyosin in parasitic worms and the counterintuitive, but well documented protection against allergic reactivity by some chronic helminth infections is discussed.     

恩度联合化疗治疗老年晚期非小细胞肺癌25例临床护理

目的:探讨恩度(重组人血管内皮抑制素)联合含铂化疗方案治疗老年晚期非小细胞肺癌(NSCLC)的疗效和不良反应护理。方法:将老年晚期NSCLC患者50例随机分为两组各25例,对照组采用NP方案(长春瑞滨+顺铂)治疗,观察组采用NP方案+恩度治疗,21 d为1个周期,2个周期治疗结束后对其疗效、生活质量及不良反应进行评价,并随访至少1年统计生存率。结果:观察组有效率为80.0%,6个月、12个月生存率分别为96.0%、88.0%,生活质量提高率为76.0%;对照组有效率为44.0%,6个月、12个月生存率分别为44.0%、20.0%,生活质量提高率为20.0%。以上两组比较差异有统计学意义(P<0.05)。结论:恩度联合化疗治疗老年晚期NSCLC,可提高患者疗效,延长生存期,提高生活质量,不良反应少。