Estimating the Yin-Yang Nature of Western Herbs: A Potential Tool Based on Antioxidation-Oxidation Theory

Background

One of the biggest obstacles to progress in traditional Chinese medicine (TCM) development in Western countries is the difficulty of applying the traditional concepts to the Western medicinal plants, which are not traditionally described in ancient literature. During recent years, new advances in the field of understanding Yin/Yang aspects from a modern bioscientific point of view have led to the conclusion that antioxidationoxidation concepts might mirror a Yin-Yang relationship.

Methods

This study was intended to integrate the Yin-Yang theory of the traditional Chinese medicine with modern antioxidation-oxidation theory, and to propose a biochemical tool based on redox parameters (e.g. antioxidant capacity, chemiluminescence-CL signal inducing capacity), usable for the classification of Western medicinal plants from Yin/Yang perspective. Trolox equivalent antioxidant capacity (TEAC) of six vegetal aqueous extracts (Symphitum officinalae (radix)-SYM, Inula helenium (radix)-INU, Calendula officinalis (flores)-CAL, Angelica arhanghelica (folium)ANG(F), Angelica arhanghelica (radix)-ANG(R), Ecbalium Elaterium (fruits)-ECB) and luminol-enhanced chemiluminescence of PMNL on addition of these vegetal extracts were measured. Percentages from the maximal or minimal values obtained were calculated for each extract (TEAC%, PMNL stimulation%, PMNL inhibition%, relative speed of action% (RSA%%)), specific Yin-Yang significance was assigned to each relative parameter. In the end, an integration of all the relative values was done, in order to find a global ”Yin” or a ”Yang” trait of each vegetal extract.

Results

TEAC decreased in the following order: SYM > INU > CAL >ANG(F) > ANG(R > ECB. Three vegetal extracts (SYM > INU > ECB) decreased the luminol-enhanced chemiluminescence of PMNL, two (ANG(R) > ANG(F)) increased it, while one (CAL) had a dual effect. After the integration of the percentages, CAL was found to have a global ”Yang” trait, while the rest of the plants had a global ”Yin” trait.

Conclusions

TEAC% and PMNL inhibition% appears to correlate with the Yin properties of herbs, while PMNL stimulation% and RSA% might correlate with Yang aspects within the formal TCM classification system, and may be useful criteria in describing the Western herbs from a TCM point of view.     

穴位贴敷联合八段锦功法对阳虚体质患者的护理效果

目的探讨穴位贴敷联合八段锦功法对阳虚体质患者的护理效果。方法选取2018年6月至2019年8月在我院门诊治疗的阳虚体质患者84例为研究对象,随机将其等分为对照组和观察组,对照组给予常规护理,观察组在对照组基础上给予穴位贴敷联合八段锦功法的护理方法。比较两组综合疗效、阳虚质积分和出现阳虚症状的情况。结果观察组总有效率高于对照组,阳虚质积分低于对照组,观察组阳虚症状出现例次明显少于对照组,差异有统计学意义(P<0.05)。结论穴位贴敷联合八段锦功法能有效改善阳虚质,提高阳虚患者的生活质量,值得推广应用。     

Growth Responses During 3 Years of Growth Hormone Treatment in Children and Adolescents With Growth Hormone Deficiency: Comparison Between Idiopathic,Organic and Isolated Growth Hormone Deficiency,and Multiple Pituitary Hormone Deficiency

BackgroundThe study aimed to compare the growth responses to 3 years of growth hormone (GH) treatment in children and adolescents with GH deficiency (GHD) according to idiopathic, organic, isolated (IGHD), and multiple pituitary hormone deficiency (MPHD).MethodsTotal 163 patients aged 2–18 years (100 males and 63 females; 131 idiopathic and 32 organic GHD; 129 IGHD and 34 MPHD) were included from data obtained from the LG Growth Study. Parameters of growth responses and biochemical results were compared during the 3-year GH treatment.ResultsThe baseline age, bone age (BA), height (Ht) standard deviation score (SDS), weight SDS, mid-parental Ht SDS, predicted adult Ht (PAH) SDS, and insulin like growth factor-1 (IGF-1) SDS were significantly higher in the organic GHD patients than in the idiopathic GHD patients, but peak GH on the GH-stimulation test, baseline GH dose, and mean 3-year-GH dosage were higher in the idiopathic GHD patients than in the organic GHD patients. The prevalence of MPHD was higher in the organic GHD patients than in the idiopathic GHD patients. Idiopathic MPHD subgroup showed the largest increase for the ΔHt SDS and ΔPAH SDS during GH treatment, and organic MPHD subgroup had the smallest mean increase after GH treatment, depending on ΔIGF-1 SDS and ΔIGF binding protein-3 (IGFBP-3) SDS. The growth velocity and the parental-adjusted Ht gain were greater in the idiopathic GHD patients than the organic GHD patients during the 3-year GH treatment, which may have been related to the different GH dose, ΔIGF-1 SDS, and ΔIGFBP-3 SDS between two groups. Multiple linear regression analysis revealed that baseline IGF-1 SDS, BA, and MPH SDS in idiopathic group and baseline HT SDS in organic group are the most predictable parameters for favorable 3-year-GH treatment.ConclusionThe 3-year-GH treatment was effective in both idiopathic and organic GHD patients regardless of the presence of MPHD or underlying causes, but their growth outcomes were not constant with each other. Close monitoring along with appropriate dosage of GH and annual growth responses, not specific at baseline, are more important in children and adolescents with GHD for long-term treatment.Trial RegistrationClinicalTrials.gov Identifier: {"type":"clinical-trial","attrs":{"text":"NCT01604395","term_id":"NCT01604395"}}NCT01604395     

温阳化湿法治疗多囊卵巢综合征

多囊卵巢综合征为育龄期女性临床常见病及多发病,作者依据吾师的治疗经验浅谈中医对多囊卵巢综合征病因病机及治法的认识。     

清热醒神颗粒治疗脑卒中阳闭证的临床研究

目的 :观察清热醒神颗粒治疗脑卒中阳闭证的临床疗效。方法 :选择符合脑卒中中西医诊断标准及中医证候诊断为阳闭证病人 78例 ,随机分为治疗组 46例和对照组 3 2例。治疗组运用清热醒神颗粒配合醒脑净注射液静脉输注 ,对照组单用醒脑净注射液静脉输注 ,治疗2 1d后采用脑卒中疗效评定标准和Glasgow意识障碍判断标准评价临床疗效及意识障碍改善情况。结果 :治疗组临床疗效及意识障碍改善明显优于对照组 ,有统计学意义 (P <0 .0 5 )。结论 :清热醒神颗粒能明显提高脑卒中阳闭证的治疗效果 ,是治疗脑卒中阳闭证安全有效的药物。     

纤维肌痛综合征的经络辨治

纤维肌痛综合征(fibromyalgia syndrome,FS)是一种风湿免疫性疾病,发病率高居风湿病第3位。它以患者全身的肌肉疼痛为特征性表现,同时伴有精神、神经症状,目前尚没有理想的治疗方法。本文以中医理论为指导,对纤维肌痛综合征的病因病机从经络的角度进行分析,根据患者疼痛部位定位对应所属经络进行综合辨证,提出FS可能与阳经的气化不利有关,并以此指导治疗,试图探求更好的物理学治疗手段。     

胃美舒冲剂联合莫沙必利治疗肝郁脾虚型功能性消化不良并抑郁症的临床疗效

目的：本研究探讨胃美舒冲剂联合莫沙必利治疗肝郁脾虚型功能性消化不良并抑郁症的临床疗效。方法：入选患者90例,通过抽签将患者随机分为两组,其中治疗组45例,对照组45例,对照组口服用莫沙必利分散片,治疗组在西药对照组的基础上,加用胃美舒免煎冲剂,水冲服300ml,每日2次,每次150ml。饭前半小时口服,连服8周。随访患者的临床症状,HAMD量表及SDS量表的得分。结果：两组患者的临床疗效果比较,治疗组的总有效率为（91.1%vs 75.6%）,差异有统计学意义,（P＜0.05）。两组在治疗后的抑郁HDMA及SDS评分比较：治疗组明显低于对照组差异均有统计学意义,（P＜0.05）;两组患者治疗后,常见不良反应轻微,两组差异无统计学意义（P＞0.05）。结论：莫沙必利的基础上加用胃美舒冲剂能够很好的改善患者的临床症状,降低了患者的抑郁相关评分,患者依从性较好,不良反应少且轻微,值得临床推广。     

Impact of micronutrient deficiency & malnutrition in systemic sclerosis: Cohort study and literature review

Objectives

The purpose of our study was to determine the prevalence and risk factors associated with malnutrition, and selenium (Se) and vitamin C (vitC) deficiencies in systemic sclerosis (SSc) patients.

补阳还五汤对气虚血瘀症代谢综合征患者血液流变学指标的影响

目的探讨补阳还五汤对代谢综合征（MS）属于气虚血瘀患者血液流变学指标和气虚血瘀证的影响。方法将78例MS属于气虚血瘀患者随机分为对照组40例和治疗组38例。两组均控制血糖、血压及血脂,控制达标一月。治疗组在此基础上加用补阳还五汤治疗,疗程4周。同时观察两组患者治疗前后中医证候积分、血液流变学指标。结果治疗后治疗组中医证候积分改善明显优于对照组（P〈0．01）,血液流变学各项指标较治疗前显著下降（P〈0．01）;且明显优于对照组（P〈0．01）。结论补阳还五汤能改善MS患者的气虚血瘀症状和血液流变学异常。     

Prevalence and Risk Factors for Iron Deficiency Anemia in the Korean Population: Results of the Fifth Korea National Health and Nutrition Examination Survey

This study assessed the prevalence of, and risk factors for, iron deficiency (ID) and iron deficiency anemia (IDA) among participants of the fifth Korean Health and Nutrition Examination Survey, 2010. Of 8,958 participants, 6,758 individuals ≥10 yr had sufficient data for the analysis of anemia and iron status. ID was defined as a transferrin saturation <10% or serum ferritin <15 µg/L. The prevalence of ID and IDA was 2.0% (95% confidence interval [CI], 1.3%-2.6%) and 0.7% (95% CI, 0.3%-1.0%), respectively, in males, and 22.4% (95% CI, 20.7%-24.2%) and 8.0% (95% CI, 6.8%-9.2%), respectively, in females. In reproductive age females, the prevalence of ID and IDA was 31.4% (95% CI, 28.9%-33.8%) and 11.5% (95% CI, 9.6%-13.4%), respectively. Compared to the prevalence of IDA in adult males 18-49 yr, the relative risks of IDA in adults ≥65 yr, lactating females, premenopausal females, and pregnant females were 8.1, 35.7, 42.8, and 95.5, respectively. Low income, underweight, iron- or vitamin C-poor diets were also associated with IDA. For populations with defined risk factors in terms of age, gender, physiological state and socioeconomic and nutritional status, national health policy to reduce IDA is needed.

Graphical Abstract

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