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31.
Shogo Tajima Michihiko Waki 《International journal of clinical and experimental pathology》2015,8(1):989-994
Cystic partially differentiated nephroblastoma (CPDN) is extremely rare in adults. Only 2 cases have been documented in the English literature. Herein, we present a third case of CPDN with unique morphological and immunohistochemical features. A 45-year-old man had a multicystic right renal mass, with a maximum diameter of 3 cm on magnetic resonance imaging. Being unable to rule out malignancy, partial nephrectomy was performed. The surgically resected specimen contained a multicystic mass, 3 × 3 × 2.5 cm in size, without an expansile solid nodule. Histopathological examination revealed nephroblastomatous elements without identifiable blastema; transition from cap-mesenchyme-like cells to an immature glomerulus was observed and maturing tubules and a glomerulus were present. Despite the lack of a blastema, the diagnosis of CPDN was the most appropriate. Immunohistochemical WT1 expression imitated the pattern of ongoing normal nephrogenesis. Therefore, we believe that the blastema disappeared because of maturation. 相似文献
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B cell-activating factor of the TNF family (BAFF) is an essential B cell survival factor. However, high levels of BAFF promote systemic lupus erythematosus (SLE) in mice and humans. Belimumab (anti-human BAFF) limits B cell survival and is approved for use in patients with SLE. Surprisingly, the efficacy of rituximab (anti-human CD20) in SLE remains controversial, despite depleting B cells more potently than belimumab. This raises the question of whether B cell depletion is really the mechanism of action of belimumab. In BAFF transgenic mice, SLE development is T cell-independent but relies on innate activation of B cells via TLRs, and TLR expression is modulated by the BAFF receptor TACI. Here, we show that loss of TACI on B cells protected against BAFF-mediated autoimmune manifestations while preserving B cells, suggesting that loss of BAFF signaling through TACI rather than loss of B cells may underpin the effect of belimumab in the clinic. Therefore, B cell-sparing blockade of TACI may offer a more specific and safer therapeutic alternative to broad B cell depletion in SLE. 相似文献
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目的:研究急性白血病患者肾母细胞瘤基因(WT1)、黑色素瘤优先表达抗原(PRAME)、ETS相关基因(ERG)、硫氧还蛋白-2(TRX-2)基因表达及其与疾病分型、疗效的关系.方法:将本院收治的90例白血病患者纳入研究的白血病组,将同期体检健康者纳入健康组;进一步根据分型将白血病患者分为ALL组和AML组,根据化疗后疗效将白血病患者分为完全缓解组和复发组.采集患者的外周血,检测WT1、PRAME、ERG、TRX-2基因的mRNA含量.结果:白血病组血液中WT1、PRAME、ERG、TRX-2基因的mRNA含量高于对照组,差异有统计学意义(P<0.05);AML组血液中WT1、PRAME、ERG、TRX-2基因的mRNA含量高于ALL组,差异有统计学意义(P<0.05);复发组的血液中WT1、PRAME、ERG、TRX-2基因的mRNA含量高于完全缓解组,差异有统计学意义(P<0.05).结论:WT1、PRAME、ERG、TRX-2基因异常高表达与白细胞的发生有关,也与疾病的分型、化疗的效果密切相关. 相似文献
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Sang Hwa Lee Hyunkyung Kim Wook Youn Kim Hye Seung Han So Dug Lim Wan Seop Kim Sehun Kim Tae Sook Hwang 《Pathology international》2013,63(5):252-259
We evaluated p53, KRAS, BRAF and CTNNB1 mutation and p53, WT1, p16 and beta‐catenin expression in 31 ovarian high‐grade serous adenocarcinoma. Twenty‐five (80.6%) tumors contained functional mutations of p53; three frameshift, four nonsense and 19 missense mutations. None of the tumors showed KRAS, BRAF or CTNNB1 mutation. In all 18 tumors with missense mutations, ≥60% of tumor cells were strongly positive for p53 immunostaining whereas all tumors with frameshift or nonsense mutations were completely negative. Missense mutation was correlated with diffuse and strong imunoreaction and frameshift/nonsense mutation was correlated with completely negative immunoreaction (P = 0.000). Tumors with wild‐type p53 revealed a wide range of immunostaining patterns. In 27 (87.1%) and 18 (58.1%) tumors, ≥50% of tumor cells were moderate to strongly positive for WT1 and p16, respectively. A considerable intratumoral heterogeneity for p16 expression was present. None of the tumors demonstrated nuclear beta‐catenin expression. p53 mutations appear to be a powerful molecular marker for ovarian high‐grade serous adenocarcinoma. Using p53 with an appropriate interpretation criteria together with WT1, p16 and beta‐catenin, most of the high‐grade serous adenocarcinoma could be distinguished from other ovarian tumors. 相似文献
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Saireudee Chaturantabut Arkadi Shwartz Kimberley J. Evason Andrew G. Cox Kyle Labella Arnout G. Schepers Song Yang Mariana Acuña Yariv Houvras Liliana Mancio-Silva Shannon Romano Daniel A. Gorelick David E. Cohen Leonard I. Zon Sangeeta N. Bhatia Trista E. North Wolfram Goessling 《Gastroenterology》2019,156(6):1788-1804.e13
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Anja K. Büscher Bodo B. Beck Anette Melk Julia Hoefele Birgitta Kranz Daniel Bamborschke Sabrina Baig B?rbel Lange-Sperandio Theresa Jungraithmayr Lutz T. Weber Markus J. Kemper Burkhard T?nshoff Peter F. Hoyer Martin Konrad Stefanie Weber 《Clinical journal of the American Society of Nephrology》2016,11(2):245-253